Preoperative risk stratification models after radical cystectomy for bladder cancer: A multi‐center study
Objective We investigated preoperative patient factors associated with prognosis in 263 bladder cancer (BC) patients undergoing radical cystectomy (RC). We also developed new risk stratification models for prognosis. Methods This retrospective study included patients treated at Tottori University Ho...
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| Veröffentlicht in: | International journal of urology 2024-11, Vol.31 (11), p.1278-1287 |
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| container_title | International journal of urology |
| container_volume | 31 |
| creator | Yamane, Hiroshi Morizane, Shuichi Honda, Masashi Muraoka, Kuniyasu Oono, Hirofumi Isoyama, Tadahiro Ono, Koji Sejima, Takehiro Kadowaki, Hiroyuki Takenaka, Atsushi |
| description | Objective
We investigated preoperative patient factors associated with prognosis in 263 bladder cancer (BC) patients undergoing radical cystectomy (RC). We also developed new risk stratification models for prognosis.
Methods
This retrospective study included patients treated at Tottori University Hospital and affiliated hospitals between January 2010 and December 2019. The relationship between preoperative patient factors and overall recurrence‐free and cancer‐specific survival (CSS) was analyzed. The modified Glasgow prognosis score (mGPS) was calculated using serum albumin and C‐reactive protein (CRP) levels. Statistical analyses included the log‐rank test and Cox proportional hazards regression.
Results
Eastern Cooperative Oncology Group performance status (ECOG‐PS), mGPS, and clinical tumor stage independently predicted CSS in multivariate analysis. A new risk stratification model included ECOG‐PS ≥2, clinical tumor stage ≥3, serum albumin 0.5 mg/dL. Risk groups were defined as 0 factors (low risk), 1–2 factors (intermediate risk), and 3–4 factors (high risk). High‐risk patients showed significantly poorer 3‐year cancer‐free survival: 86.9% (low risk), 76.7% (intermediate risk), and 50.0% (high risk).
Conclusions
ECOG‐PS, clinical tumor stage, and mGPS are predictive of poor cancer‐free survival post‐RC for BC. Our model offers the potential for prognostic prediction in these patients. |
| doi_str_mv | 10.1111/iju.15560 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3092871159</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3092871159</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2430-f13cee20d68d9ce7bed5c520acb799f0059ca54937f661cb2fa231c1145b46d83</originalsourceid><addsrcrecordid>eNp1kctO3TAQhq2qqBxoF32BylI3dBHw2M7F3SHUchFSuyhry7HHUg5JfGonoOz6CDwjT4IPB7qoVC_Gmplvfo3mJ-QjsGPI76Rbz8dQlhV7Q1YgJS84k_wtWTEFqmig5vvkIKU1YyA4NO_IvlAgGedqRW5_RgwbjGbq7pDGLt3SNG0z39kcw0iH4LBP1PgJI43G5XpP7ZImtFMYFupDpG1vnMtta0aL8Ss9pcPcT93jnweL43YuTbNb3pM9b_qEH17-Q3Lz_duvs4vi-sf55dnpdWG5FKzwICwiZ65qnLJYt-hKW3JmbFsr5RkrlTWlVKL2VQW25d5wARZAlq2sXCMOydFOdxPD7xnTpIcuWex7M2KYkxZM8aYGKFVGP_-DrsMcx7ydFsAFr1Qleaa-7CgbQ0oRvd7EbjBx0cD01gGdHdDPDmT204vi3A7o_pKvJ8_AyQ6473pc_q-kL69udpJPho6RrQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3123269642</pqid></control><display><type>article</type><title>Preoperative risk stratification models after radical cystectomy for bladder cancer: A multi‐center study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Yamane, Hiroshi ; Morizane, Shuichi ; Honda, Masashi ; Muraoka, Kuniyasu ; Oono, Hirofumi ; Isoyama, Tadahiro ; Ono, Koji ; Sejima, Takehiro ; Kadowaki, Hiroyuki ; Takenaka, Atsushi</creator><creatorcontrib>Yamane, Hiroshi ; Morizane, Shuichi ; Honda, Masashi ; Muraoka, Kuniyasu ; Oono, Hirofumi ; Isoyama, Tadahiro ; Ono, Koji ; Sejima, Takehiro ; Kadowaki, Hiroyuki ; Takenaka, Atsushi</creatorcontrib><description>Objective
We investigated preoperative patient factors associated with prognosis in 263 bladder cancer (BC) patients undergoing radical cystectomy (RC). We also developed new risk stratification models for prognosis.
Methods
This retrospective study included patients treated at Tottori University Hospital and affiliated hospitals between January 2010 and December 2019. The relationship between preoperative patient factors and overall recurrence‐free and cancer‐specific survival (CSS) was analyzed. The modified Glasgow prognosis score (mGPS) was calculated using serum albumin and C‐reactive protein (CRP) levels. Statistical analyses included the log‐rank test and Cox proportional hazards regression.
Results
Eastern Cooperative Oncology Group performance status (ECOG‐PS), mGPS, and clinical tumor stage independently predicted CSS in multivariate analysis. A new risk stratification model included ECOG‐PS ≥2, clinical tumor stage ≥3, serum albumin <3.5 g/dL, and serum CRP >0.5 mg/dL. Risk groups were defined as 0 factors (low risk), 1–2 factors (intermediate risk), and 3–4 factors (high risk). High‐risk patients showed significantly poorer 3‐year cancer‐free survival: 86.9% (low risk), 76.7% (intermediate risk), and 50.0% (high risk).
Conclusions
ECOG‐PS, clinical tumor stage, and mGPS are predictive of poor cancer‐free survival post‐RC for BC. Our model offers the potential for prognostic prediction in these patients.</description><identifier>ISSN: 0919-8172</identifier><identifier>ISSN: 1442-2042</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.15560</identifier><identifier>PMID: 39140229</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Aged ; Aged, 80 and over ; Albumin ; Bladder cancer ; C-Reactive Protein - analysis ; Cystectomy - adverse effects ; Disease-Free Survival ; Female ; Humans ; Male ; Medical prognosis ; Middle Aged ; modified Glasgow prognosis score ; Multivariate analysis ; Neoplasm Staging ; Patients ; Preoperative Period ; Prognosis ; Proportional Hazards Models ; Proteins ; radical cystectomy ; Retrospective Studies ; Risk Assessment - methods ; Risk Assessment - statistics & numerical data ; Risk Factors ; Risk groups ; Serum Albumin - analysis ; Statistical analysis ; Survival ; Tumors ; Urinary Bladder Neoplasms - mortality ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - surgery ; Urological surgery</subject><ispartof>International journal of urology, 2024-11, Vol.31 (11), p.1278-1287</ispartof><rights>2024 The Japanese Urological Association.</rights><rights>2024 The Japanese Urological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2430-f13cee20d68d9ce7bed5c520acb799f0059ca54937f661cb2fa231c1145b46d83</cites><orcidid>0000-0003-2857-8181 ; 0000-0003-3654-2672</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiju.15560$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiju.15560$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39140229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamane, Hiroshi</creatorcontrib><creatorcontrib>Morizane, Shuichi</creatorcontrib><creatorcontrib>Honda, Masashi</creatorcontrib><creatorcontrib>Muraoka, Kuniyasu</creatorcontrib><creatorcontrib>Oono, Hirofumi</creatorcontrib><creatorcontrib>Isoyama, Tadahiro</creatorcontrib><creatorcontrib>Ono, Koji</creatorcontrib><creatorcontrib>Sejima, Takehiro</creatorcontrib><creatorcontrib>Kadowaki, Hiroyuki</creatorcontrib><creatorcontrib>Takenaka, Atsushi</creatorcontrib><title>Preoperative risk stratification models after radical cystectomy for bladder cancer: A multi‐center study</title><title>International journal of urology</title><addtitle>Int J Urol</addtitle><description>Objective
We investigated preoperative patient factors associated with prognosis in 263 bladder cancer (BC) patients undergoing radical cystectomy (RC). We also developed new risk stratification models for prognosis.
Methods
This retrospective study included patients treated at Tottori University Hospital and affiliated hospitals between January 2010 and December 2019. The relationship between preoperative patient factors and overall recurrence‐free and cancer‐specific survival (CSS) was analyzed. The modified Glasgow prognosis score (mGPS) was calculated using serum albumin and C‐reactive protein (CRP) levels. Statistical analyses included the log‐rank test and Cox proportional hazards regression.
Results
Eastern Cooperative Oncology Group performance status (ECOG‐PS), mGPS, and clinical tumor stage independently predicted CSS in multivariate analysis. A new risk stratification model included ECOG‐PS ≥2, clinical tumor stage ≥3, serum albumin <3.5 g/dL, and serum CRP >0.5 mg/dL. Risk groups were defined as 0 factors (low risk), 1–2 factors (intermediate risk), and 3–4 factors (high risk). High‐risk patients showed significantly poorer 3‐year cancer‐free survival: 86.9% (low risk), 76.7% (intermediate risk), and 50.0% (high risk).
Conclusions
ECOG‐PS, clinical tumor stage, and mGPS are predictive of poor cancer‐free survival post‐RC for BC. Our model offers the potential for prognostic prediction in these patients.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Albumin</subject><subject>Bladder cancer</subject><subject>C-Reactive Protein - analysis</subject><subject>Cystectomy - adverse effects</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>modified Glasgow prognosis score</subject><subject>Multivariate analysis</subject><subject>Neoplasm Staging</subject><subject>Patients</subject><subject>Preoperative Period</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Proteins</subject><subject>radical cystectomy</subject><subject>Retrospective Studies</subject><subject>Risk Assessment - methods</subject><subject>Risk Assessment - statistics & numerical data</subject><subject>Risk Factors</subject><subject>Risk groups</subject><subject>Serum Albumin - analysis</subject><subject>Statistical analysis</subject><subject>Survival</subject><subject>Tumors</subject><subject>Urinary Bladder Neoplasms - mortality</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - surgery</subject><subject>Urological surgery</subject><issn>0919-8172</issn><issn>1442-2042</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctO3TAQhq2qqBxoF32BylI3dBHw2M7F3SHUchFSuyhry7HHUg5JfGonoOz6CDwjT4IPB7qoVC_Gmplvfo3mJ-QjsGPI76Rbz8dQlhV7Q1YgJS84k_wtWTEFqmig5vvkIKU1YyA4NO_IvlAgGedqRW5_RgwbjGbq7pDGLt3SNG0z39kcw0iH4LBP1PgJI43G5XpP7ZImtFMYFupDpG1vnMtta0aL8Ss9pcPcT93jnweL43YuTbNb3pM9b_qEH17-Q3Lz_duvs4vi-sf55dnpdWG5FKzwICwiZ65qnLJYt-hKW3JmbFsr5RkrlTWlVKL2VQW25d5wARZAlq2sXCMOydFOdxPD7xnTpIcuWex7M2KYkxZM8aYGKFVGP_-DrsMcx7ydFsAFr1Qleaa-7CgbQ0oRvd7EbjBx0cD01gGdHdDPDmT204vi3A7o_pKvJ8_AyQ6473pc_q-kL69udpJPho6RrQ</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Yamane, Hiroshi</creator><creator>Morizane, Shuichi</creator><creator>Honda, Masashi</creator><creator>Muraoka, Kuniyasu</creator><creator>Oono, Hirofumi</creator><creator>Isoyama, Tadahiro</creator><creator>Ono, Koji</creator><creator>Sejima, Takehiro</creator><creator>Kadowaki, Hiroyuki</creator><creator>Takenaka, Atsushi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2857-8181</orcidid><orcidid>https://orcid.org/0000-0003-3654-2672</orcidid></search><sort><creationdate>202411</creationdate><title>Preoperative risk stratification models after radical cystectomy for bladder cancer: A multi‐center study</title><author>Yamane, Hiroshi ; Morizane, Shuichi ; Honda, Masashi ; Muraoka, Kuniyasu ; Oono, Hirofumi ; Isoyama, Tadahiro ; Ono, Koji ; Sejima, Takehiro ; Kadowaki, Hiroyuki ; Takenaka, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2430-f13cee20d68d9ce7bed5c520acb799f0059ca54937f661cb2fa231c1145b46d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Albumin</topic><topic>Bladder cancer</topic><topic>C-Reactive Protein - analysis</topic><topic>Cystectomy - adverse effects</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>modified Glasgow prognosis score</topic><topic>Multivariate analysis</topic><topic>Neoplasm Staging</topic><topic>Patients</topic><topic>Preoperative Period</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Proteins</topic><topic>radical cystectomy</topic><topic>Retrospective Studies</topic><topic>Risk Assessment - methods</topic><topic>Risk Assessment - statistics & numerical data</topic><topic>Risk Factors</topic><topic>Risk groups</topic><topic>Serum Albumin - analysis</topic><topic>Statistical analysis</topic><topic>Survival</topic><topic>Tumors</topic><topic>Urinary Bladder Neoplasms - mortality</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - surgery</topic><topic>Urological surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamane, Hiroshi</creatorcontrib><creatorcontrib>Morizane, Shuichi</creatorcontrib><creatorcontrib>Honda, Masashi</creatorcontrib><creatorcontrib>Muraoka, Kuniyasu</creatorcontrib><creatorcontrib>Oono, Hirofumi</creatorcontrib><creatorcontrib>Isoyama, Tadahiro</creatorcontrib><creatorcontrib>Ono, Koji</creatorcontrib><creatorcontrib>Sejima, Takehiro</creatorcontrib><creatorcontrib>Kadowaki, Hiroyuki</creatorcontrib><creatorcontrib>Takenaka, Atsushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamane, Hiroshi</au><au>Morizane, Shuichi</au><au>Honda, Masashi</au><au>Muraoka, Kuniyasu</au><au>Oono, Hirofumi</au><au>Isoyama, Tadahiro</au><au>Ono, Koji</au><au>Sejima, Takehiro</au><au>Kadowaki, Hiroyuki</au><au>Takenaka, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative risk stratification models after radical cystectomy for bladder cancer: A multi‐center study</atitle><jtitle>International journal of urology</jtitle><addtitle>Int J Urol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>31</volume><issue>11</issue><spage>1278</spage><epage>1287</epage><pages>1278-1287</pages><issn>0919-8172</issn><issn>1442-2042</issn><eissn>1442-2042</eissn><abstract>Objective
We investigated preoperative patient factors associated with prognosis in 263 bladder cancer (BC) patients undergoing radical cystectomy (RC). We also developed new risk stratification models for prognosis.
Methods
This retrospective study included patients treated at Tottori University Hospital and affiliated hospitals between January 2010 and December 2019. The relationship between preoperative patient factors and overall recurrence‐free and cancer‐specific survival (CSS) was analyzed. The modified Glasgow prognosis score (mGPS) was calculated using serum albumin and C‐reactive protein (CRP) levels. Statistical analyses included the log‐rank test and Cox proportional hazards regression.
Results
Eastern Cooperative Oncology Group performance status (ECOG‐PS), mGPS, and clinical tumor stage independently predicted CSS in multivariate analysis. A new risk stratification model included ECOG‐PS ≥2, clinical tumor stage ≥3, serum albumin <3.5 g/dL, and serum CRP >0.5 mg/dL. Risk groups were defined as 0 factors (low risk), 1–2 factors (intermediate risk), and 3–4 factors (high risk). High‐risk patients showed significantly poorer 3‐year cancer‐free survival: 86.9% (low risk), 76.7% (intermediate risk), and 50.0% (high risk).
Conclusions
ECOG‐PS, clinical tumor stage, and mGPS are predictive of poor cancer‐free survival post‐RC for BC. Our model offers the potential for prognostic prediction in these patients.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39140229</pmid><doi>10.1111/iju.15560</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2857-8181</orcidid><orcidid>https://orcid.org/0000-0003-3654-2672</orcidid></addata></record> |
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| subjects | Aged Aged, 80 and over Albumin Bladder cancer C-Reactive Protein - analysis Cystectomy - adverse effects Disease-Free Survival Female Humans Male Medical prognosis Middle Aged modified Glasgow prognosis score Multivariate analysis Neoplasm Staging Patients Preoperative Period Prognosis Proportional Hazards Models Proteins radical cystectomy Retrospective Studies Risk Assessment - methods Risk Assessment - statistics & numerical data Risk Factors Risk groups Serum Albumin - analysis Statistical analysis Survival Tumors Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery Urological surgery |
| title | Preoperative risk stratification models after radical cystectomy for bladder cancer: A multi‐center study |
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