CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis

Tertiary lymphoid structures (TLSs) are associated with enhanced immunity in tumors. However, their formation and functions in colorectal cancer liver metastasis (CRLM) remain unclear. Here, we reveal that intra- and peri-tumor mature TLSs (TLS+) are associated with improved clinical outcomes than T...

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Veröffentlicht in:	Cancer cell 2024-08, Vol.42 (8), p.1370-1385.e9
Hauptverfasser:	Zhang, Yifan, Liu, Guangjian, Zeng, Qianwen, Wu, Wenrui, Lei, Kai, Zhang, Chuankai, Tang, Miaoling, Zhang, Yuting, Xiang, Xiao, Tan, Li, Cui, Rui, Qin, Si, Song, Xinming, Yin, Changjun, Chen, Zhihang, Kuang, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology CCL19 Cell Line, Tumor Chemokine CCL19 - genetics Chemokine CCL19 - metabolism colorectal cancer liver metastasis Colorectal Neoplasms - immunology Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Female Fibroblasts - immunology Fibroblasts - metabolism humanized mouse Humans IgG plasma cell Immunoglobulin G - immunology Liver Neoplasms - immunology Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - secondary Mice monoclonal antibody Plasma Cells - immunology Plasma Cells - metabolism single-cell RNA sequencing spatial transcriptomics Tertiary lymphoid structures Tertiary Lymphoid Structures - immunology Tertiary Lymphoid Structures - pathology
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