Capillarity-powered and CRISPR/Cas12a-responsive DNA hydrogel distance sensor for highly sensitive visual detection of HPV DNA

The rapid and specific identification and sensitive detection of human papillomavirus (HPV) infection is critical for preventing cervical cancer, particularly in resource-limited regions. In this work, we hope to propose a capillarity-powered and CRISPR/Cas12a-responsive DNA hydrogel distance sensor...

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Veröffentlicht in:	Biosensors & bioelectronics 2024-11, Vol.264, p.116657, Article 116657
Hauptverfasser:	Pian, Hongru, Wang, Hui, Wang, Honghong, Tang, Fu, Li, Zhengping
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Biosensing Techniques - instrumentation Biosensing Techniques - methods CRISPR-Associated Proteins - chemistry CRISPR-Cas Systems CRISPR/Cas12a Distance sensor DNA detection DNA hydrogel DNA, Viral - analysis DNA, Viral - genetics Endodeoxyribonucleases - chemistry Female Humans Hydrogels - chemistry Limit of Detection Papillomaviridae - genetics Papillomavirus Infections - diagnosis Papillomavirus Infections - virology Point-of-care testing Recombinase polymerase reaction (RPA)
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