B1-MRF: Large dynamic range MRF-based absolute B 1 + mapping in the human body at 7T
This study aims to map the transmit magnetic field ( ) in the human body at 7T using MR fingerprinting (MRF), with a focus on achieving high accuracy and precision across a large dynamic range, particularly at low flip angles (FAs). A FLASH-based MRF sequence (B1-MRF) with high sensitivity was devel...
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| Veröffentlicht in: | Magnetic resonance in medicine 2024-12, Vol.92 (6), p.2473 |
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| container_title | Magnetic resonance in medicine |
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| creator | Lutz, Max Aigner, Christoph Stefan Flassbeck, Sebastian Krueger, Felix Gatefait, Constance G F Kolbitsch, Christoph Silemek, Berk Seifert, Frank Schaeffter, Tobias Schmitter, Sebastian |
| description | This study aims to map the transmit magnetic field (
) in the human body at 7T using MR fingerprinting (MRF), with a focus on achieving high accuracy and precision across a large dynamic range, particularly at low flip angles (FAs).
A FLASH-based MRF sequence (B1-MRF) with high
sensitivity was developed. Phantom and in vivo abdominal imaging were performed at 7T, and the results were compared with established reference methods, including a slow but precise preparation-based method (PEX), saturated TurboFLASH (satTFL), actual flip angle imaging (AFI) and Bloch-Siegert shift (BSS).
The MRF signal curve was highly sensitive to
, while T
sensitivity was comparatively low. The phantom experiment showed good agreement of
to PEX for a T
range of 204-1691 ms evaluated at FAs from 0° to 70°. Compared to the references, a dynamic range increase larger than a factor of two was determined experimentally. In vivo liver scans showed a strong correlation between B1-MRF, satTFL, and RPE-AFI in a low body mass index (BMI) subject (18.1 kg/m
). However, in larger BMI subjects (≥25.5 kg/m
), inconsistencies were observed in low
regions for satTFL and RPE-AFI, while B1-MRF still provided consistent results in these regions.
B1-MRF provides accurate and precise
maps over a wide range of FAs, surpassing the capabilities of existing methods in the FA range |
| doi_str_mv | 10.1002/mrm.30242 |
| format | Article |
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) in the human body at 7T using MR fingerprinting (MRF), with a focus on achieving high accuracy and precision across a large dynamic range, particularly at low flip angles (FAs).
A FLASH-based MRF sequence (B1-MRF) with high
sensitivity was developed. Phantom and in vivo abdominal imaging were performed at 7T, and the results were compared with established reference methods, including a slow but precise preparation-based method (PEX), saturated TurboFLASH (satTFL), actual flip angle imaging (AFI) and Bloch-Siegert shift (BSS).
The MRF signal curve was highly sensitive to
, while T
sensitivity was comparatively low. The phantom experiment showed good agreement of
to PEX for a T
range of 204-1691 ms evaluated at FAs from 0° to 70°. Compared to the references, a dynamic range increase larger than a factor of two was determined experimentally. In vivo liver scans showed a strong correlation between B1-MRF, satTFL, and RPE-AFI in a low body mass index (BMI) subject (18.1 kg/m
). However, in larger BMI subjects (≥25.5 kg/m
), inconsistencies were observed in low
regions for satTFL and RPE-AFI, while B1-MRF still provided consistent results in these regions.
B1-MRF provides accurate and precise
maps over a wide range of FAs, surpassing the capabilities of existing methods in the FA range < 60°. Its enhanced sensitivity at low FAs is advantageous for various applications requiring precise
estimates, potentially advancing the frontiers of ultra-high field (UHF) body imaging at 7T and beyond.</description><identifier>ISSN: 1522-2594</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.30242</identifier><identifier>PMID: 39133639</identifier><language>eng</language><publisher>United States</publisher><ispartof>Magnetic resonance in medicine, 2024-12, Vol.92 (6), p.2473</ispartof><rights>2024 Physikalisch‐Technische Bundesanstalt (PTB) and The Author(s). Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-8227-3632 ; 0000-0003-0865-9021 ; 0000-0001-9453-8992 ; 0000-0003-3618-9610 ; 0000-0002-7065-2528 ; 0009-0001-1956-3757 ; 0000-0002-4355-8368 ; 0000-0003-4410-6790</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39133639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lutz, Max</creatorcontrib><creatorcontrib>Aigner, Christoph Stefan</creatorcontrib><creatorcontrib>Flassbeck, Sebastian</creatorcontrib><creatorcontrib>Krueger, Felix</creatorcontrib><creatorcontrib>Gatefait, Constance G F</creatorcontrib><creatorcontrib>Kolbitsch, Christoph</creatorcontrib><creatorcontrib>Silemek, Berk</creatorcontrib><creatorcontrib>Seifert, Frank</creatorcontrib><creatorcontrib>Schaeffter, Tobias</creatorcontrib><creatorcontrib>Schmitter, Sebastian</creatorcontrib><title>B1-MRF: Large dynamic range MRF-based absolute B 1 + mapping in the human body at 7T</title><title>Magnetic resonance in medicine</title><addtitle>Magn Reson Med</addtitle><description>This study aims to map the transmit magnetic field (
) in the human body at 7T using MR fingerprinting (MRF), with a focus on achieving high accuracy and precision across a large dynamic range, particularly at low flip angles (FAs).
A FLASH-based MRF sequence (B1-MRF) with high
sensitivity was developed. Phantom and in vivo abdominal imaging were performed at 7T, and the results were compared with established reference methods, including a slow but precise preparation-based method (PEX), saturated TurboFLASH (satTFL), actual flip angle imaging (AFI) and Bloch-Siegert shift (BSS).
The MRF signal curve was highly sensitive to
, while T
sensitivity was comparatively low. The phantom experiment showed good agreement of
to PEX for a T
range of 204-1691 ms evaluated at FAs from 0° to 70°. Compared to the references, a dynamic range increase larger than a factor of two was determined experimentally. In vivo liver scans showed a strong correlation between B1-MRF, satTFL, and RPE-AFI in a low body mass index (BMI) subject (18.1 kg/m
). However, in larger BMI subjects (≥25.5 kg/m
), inconsistencies were observed in low
regions for satTFL and RPE-AFI, while B1-MRF still provided consistent results in these regions.
B1-MRF provides accurate and precise
maps over a wide range of FAs, surpassing the capabilities of existing methods in the FA range < 60°. Its enhanced sensitivity at low FAs is advantageous for various applications requiring precise
estimates, potentially advancing the frontiers of ultra-high field (UHF) body imaging at 7T and beyond.</description><issn>1522-2594</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpNUF9LwzAcDKK4OX3wC0geBenMvzaJb244FSaC9L380iRbpWlr0z7s26_gBB-Ou-OOeziEbilZUkLYY-jDkhMm2Bma05SxhKVanP_TM3QV4zchRGspLtGMa8p5xvUc5SuafHxtnvAW-p3D9tBAqErcQzO5KUgMRGcxmNjW4-DwClP8gAN0XdXscNXgYe_wfgzQYNPaA4YBy_waXXioo7s58QLlm5d8_ZZsP1_f18_bpEsznTDGONWl0V5xKUuTeWGN1wI8UUIRJaXiwoC3agIzkjjFtdVOgUu9KS1foPvf2a5vf0YXhyJUsXR1DY1rx1hwohnPZCbZVL07VUcTnC26vgrQH4q_I_gRDlRcEg</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Lutz, Max</creator><creator>Aigner, Christoph Stefan</creator><creator>Flassbeck, Sebastian</creator><creator>Krueger, Felix</creator><creator>Gatefait, Constance G F</creator><creator>Kolbitsch, Christoph</creator><creator>Silemek, Berk</creator><creator>Seifert, Frank</creator><creator>Schaeffter, Tobias</creator><creator>Schmitter, Sebastian</creator><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8227-3632</orcidid><orcidid>https://orcid.org/0000-0003-0865-9021</orcidid><orcidid>https://orcid.org/0000-0001-9453-8992</orcidid><orcidid>https://orcid.org/0000-0003-3618-9610</orcidid><orcidid>https://orcid.org/0000-0002-7065-2528</orcidid><orcidid>https://orcid.org/0009-0001-1956-3757</orcidid><orcidid>https://orcid.org/0000-0002-4355-8368</orcidid><orcidid>https://orcid.org/0000-0003-4410-6790</orcidid></search><sort><creationdate>20241201</creationdate><title>B1-MRF: Large dynamic range MRF-based absolute B 1 + mapping in the human body at 7T</title><author>Lutz, Max ; Aigner, Christoph Stefan ; Flassbeck, Sebastian ; Krueger, Felix ; Gatefait, Constance G F ; Kolbitsch, Christoph ; Silemek, Berk ; Seifert, Frank ; Schaeffter, Tobias ; Schmitter, Sebastian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p569-222319cb9f8377cb6f4dbf94af08480877834bafd8afd2b70e839d9e8ae5fbcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lutz, Max</creatorcontrib><creatorcontrib>Aigner, Christoph Stefan</creatorcontrib><creatorcontrib>Flassbeck, Sebastian</creatorcontrib><creatorcontrib>Krueger, Felix</creatorcontrib><creatorcontrib>Gatefait, Constance G F</creatorcontrib><creatorcontrib>Kolbitsch, Christoph</creatorcontrib><creatorcontrib>Silemek, Berk</creatorcontrib><creatorcontrib>Seifert, Frank</creatorcontrib><creatorcontrib>Schaeffter, Tobias</creatorcontrib><creatorcontrib>Schmitter, Sebastian</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lutz, Max</au><au>Aigner, Christoph Stefan</au><au>Flassbeck, Sebastian</au><au>Krueger, Felix</au><au>Gatefait, Constance G F</au><au>Kolbitsch, Christoph</au><au>Silemek, Berk</au><au>Seifert, Frank</au><au>Schaeffter, Tobias</au><au>Schmitter, Sebastian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>B1-MRF: Large dynamic range MRF-based absolute B 1 + mapping in the human body at 7T</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn Reson Med</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>92</volume><issue>6</issue><spage>2473</spage><pages>2473-</pages><issn>1522-2594</issn><eissn>1522-2594</eissn><abstract>This study aims to map the transmit magnetic field (
) in the human body at 7T using MR fingerprinting (MRF), with a focus on achieving high accuracy and precision across a large dynamic range, particularly at low flip angles (FAs).
A FLASH-based MRF sequence (B1-MRF) with high
sensitivity was developed. Phantom and in vivo abdominal imaging were performed at 7T, and the results were compared with established reference methods, including a slow but precise preparation-based method (PEX), saturated TurboFLASH (satTFL), actual flip angle imaging (AFI) and Bloch-Siegert shift (BSS).
The MRF signal curve was highly sensitive to
, while T
sensitivity was comparatively low. The phantom experiment showed good agreement of
to PEX for a T
range of 204-1691 ms evaluated at FAs from 0° to 70°. Compared to the references, a dynamic range increase larger than a factor of two was determined experimentally. In vivo liver scans showed a strong correlation between B1-MRF, satTFL, and RPE-AFI in a low body mass index (BMI) subject (18.1 kg/m
). However, in larger BMI subjects (≥25.5 kg/m
), inconsistencies were observed in low
regions for satTFL and RPE-AFI, while B1-MRF still provided consistent results in these regions.
B1-MRF provides accurate and precise
maps over a wide range of FAs, surpassing the capabilities of existing methods in the FA range < 60°. Its enhanced sensitivity at low FAs is advantageous for various applications requiring precise
estimates, potentially advancing the frontiers of ultra-high field (UHF) body imaging at 7T and beyond.</abstract><cop>United States</cop><pmid>39133639</pmid><doi>10.1002/mrm.30242</doi><orcidid>https://orcid.org/0000-0001-8227-3632</orcidid><orcidid>https://orcid.org/0000-0003-0865-9021</orcidid><orcidid>https://orcid.org/0000-0001-9453-8992</orcidid><orcidid>https://orcid.org/0000-0003-3618-9610</orcidid><orcidid>https://orcid.org/0000-0002-7065-2528</orcidid><orcidid>https://orcid.org/0009-0001-1956-3757</orcidid><orcidid>https://orcid.org/0000-0002-4355-8368</orcidid><orcidid>https://orcid.org/0000-0003-4410-6790</orcidid></addata></record> |
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| title | B1-MRF: Large dynamic range MRF-based absolute B 1 + mapping in the human body at 7T |
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