Host-specific SRSF7 regulates polymerase activity and replication of influenza A virus

Avian influenza viruses crossing the host barrier to infect humans have caused great panic in human society and seriously threatened public health. Herein, we revealed that knockdown of SRSF7 significantly down-regulated influenza virus titers and viral protein expression. We further observed for th...

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Veröffentlicht in:	Microbes and infection 2024-11, Vol.26 (8), p.105401, Article 105401
Hauptverfasser:	Zhao, Lingcai, Li, Shengmin, Deng, Lulu, Zhang, Yijia, Jiang, Chenfeng, Wei, Yurong, Xia, Jun, Ping, Jihui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dogs Gene Knockdown Techniques HEK293 Cells Host-Pathogen Interactions Humans Influenza A virus - genetics Influenza A virus - physiology Influenza, Human - virology Lysosome-associated pathway Madin Darby Canine Kidney Cells Polymerase activity (PB2627E) RNA-Dependent RNA Polymerase - genetics RNA-Dependent RNA Polymerase - metabolism Serine-Arginine Splicing Factors - genetics Serine-Arginine Splicing Factors - metabolism SRSF7 Viral Proteins - genetics Viral Proteins - metabolism Virus Replication
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