FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice

Farnesoid X receptor (FXR) is a nuclear receptor that regulates the synthesis and enterohepatic circulation of bile acids (BAs). It also regulates lipid and carbohydrate metabolism, making FXR ligands potential therapeutic agents for systemic and/or hepatic metabolic disorders. We previously synthes...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2024/08/13, Vol.47(8), pp.1429-1436
Hauptverfasser:	Iguchi, Yusuke, Yamashita, Yukiko, Gohda, Keigo, Oda, Keisuke, Fujimori, Ko, Sera, Yukihiro, Imanaka, Tsuneo, Yamaguchi, Masafumi, Une, Mizuho, Teno, Naoki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile acids Bile Acids and Salts - metabolism Body weight Carbohydrate metabolism Cholesterol Cholesterol - blood cholesterol metabolism Diet, High-Fat - adverse effects dyslipidemia farnesoid X receptor antagonist Fat metabolism fatty acid β-oxidation High cholesterol diet High fat diet Ileum Ileum - drug effects Ileum - metabolism Lipid metabolism Lipid Metabolism - drug effects Liver - drug effects Liver - metabolism Liver diseases Liver X receptors Male Metabolic disorders Mice Mice, Inbred C57BL Mice, Obese Obesity - blood Obesity - drug therapy Obesity - metabolism Oral administration Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - metabolism Toxicity Triglycerides - blood
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