Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials
Introduction Knee pain is a major cause of disability worldwide, particularly among the elderly. Current treatments, including nonsteroidal anti-inflammatory drugs and analgesics, often lead to adverse effects. Krill oil is being explored as a potential alternative, however its efficacy in managing...
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| Veröffentlicht in: | Inflammopharmacology 2024-10, Vol.32 (5), p.3109-3118 |
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| container_title | Inflammopharmacology |
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| creator | Pimentel, Túlio Queiroz, Ivo Florêncio de Mesquita, Cynthia Gallo Ruelas, Mariano Leandro, Giovanna N. Ribeiro Monteiro, Arthur Nunes Pimentel, Fernando |
| description | Introduction
Knee pain is a major cause of disability worldwide, particularly among the elderly. Current treatments, including nonsteroidal anti-inflammatory drugs and analgesics, often lead to adverse effects. Krill oil is being explored as a potential alternative, however its efficacy in managing knee symptoms remains unclear.
Methods
MEDLINE, Embase, and Cochrane databases were searched until May 2024 for studies comparing krill oil and placebo in knee pain patients. Endpoints included knee pain, stiffness, physical function, and lipid profiles (HDL-C, LDL-C, triglycerides, and total cholesterol). A restricted maximum likelihood random-effects model with standardized mean differences (SMD) and 95% confidence intervals (CI) was used. A trial sequential analysis was conducted to evaluate further research implications.
Results
We included five trials with 700 patients using krill oil for knee pain. Results showed no significant difference between krill oil and placebo for knee pain, knee stiffness, and lipid profiles. However, krill oil demonstrated a significant small effect in improving knee physical function (SMD -0.24, 95% CI [-0.41; -0.08], I
2
= 0%).Trial sequential analysis provided certainty that krill oil enhances knee physical function compared to placebo and indicated no improvement in knee pain, but the findings for knee stiffness need to be confirmed by further research.
Conclusion
This study found that krill oil supplementation did not significantly improve knee pain, stiffness, or lipid profile, although it may help knee physical function. Based on these findings, krill oil supplementation is not yet justified for knee pain. |
| doi_str_mv | 10.1007/s10787-024-01543-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3091288898</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3091288898</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-66c1658c8b34f1ae219b17cc5c3e4ad40537944795ab49dbc987dea2d04def133</originalsourceid><addsrcrecordid>eNp9Uclu1TAUtRCIPlp-gAXykk2K54EdqsogKrFp15bj3IBLYgc7afX4B_65bl_pktU90hl0dQ5Cbyg5pYTo95USbXRHmOgIlYJ3-hnaUalMJxUxz9GOWCY7oSw7Qq9qvSaEKK3sS3TELWVKarJDf7-VOE04xwnXbVkmmCGtfo054TEX_CsB4MXH9AF7XPd1hbmRARe4iXCLfRrwDKvvfPLTvsaKb-P6E68l-pYHv7cWdg-f6Dzi0kx5jn9gwCGnteRpavDBUk_Qi7EdeP14j9HVp_PLsy_dxffPX88-XnSBMbN2SgWqpAmm52KkHhi1PdUhyMBB-EEQybUVQlvpe2GHPlijB_BsIGKAkXJ-jN4dcpeS25N1dXOsAabJJ8hbdZy0gowx1jQpO0hDybUWGN1S4uzL3lHi7mdwhxlcm8E9zOB0M719zN_6GYYny7_em4AfBLVR6QcUd5230lqq_4u9A5MclrY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3091288898</pqid></control><display><type>article</type><title>Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials</title><source>MEDLINE</source><source>SpringerLink</source><creator>Pimentel, Túlio ; Queiroz, Ivo ; Florêncio de Mesquita, Cynthia ; Gallo Ruelas, Mariano ; Leandro, Giovanna N. ; Ribeiro Monteiro, Arthur ; Nunes Pimentel, Fernando</creator><creatorcontrib>Pimentel, Túlio ; Queiroz, Ivo ; Florêncio de Mesquita, Cynthia ; Gallo Ruelas, Mariano ; Leandro, Giovanna N. ; Ribeiro Monteiro, Arthur ; Nunes Pimentel, Fernando</creatorcontrib><description>Introduction
Knee pain is a major cause of disability worldwide, particularly among the elderly. Current treatments, including nonsteroidal anti-inflammatory drugs and analgesics, often lead to adverse effects. Krill oil is being explored as a potential alternative, however its efficacy in managing knee symptoms remains unclear.
Methods
MEDLINE, Embase, and Cochrane databases were searched until May 2024 for studies comparing krill oil and placebo in knee pain patients. Endpoints included knee pain, stiffness, physical function, and lipid profiles (HDL-C, LDL-C, triglycerides, and total cholesterol). A restricted maximum likelihood random-effects model with standardized mean differences (SMD) and 95% confidence intervals (CI) was used. A trial sequential analysis was conducted to evaluate further research implications.
Results
We included five trials with 700 patients using krill oil for knee pain. Results showed no significant difference between krill oil and placebo for knee pain, knee stiffness, and lipid profiles. However, krill oil demonstrated a significant small effect in improving knee physical function (SMD -0.24, 95% CI [-0.41; -0.08], I
2
= 0%).Trial sequential analysis provided certainty that krill oil enhances knee physical function compared to placebo and indicated no improvement in knee pain, but the findings for knee stiffness need to be confirmed by further research.
Conclusion
This study found that krill oil supplementation did not significantly improve knee pain, stiffness, or lipid profile, although it may help knee physical function. Based on these findings, krill oil supplementation is not yet justified for knee pain.</description><identifier>ISSN: 0925-4692</identifier><identifier>ISSN: 1568-5608</identifier><identifier>EISSN: 1568-5608</identifier><identifier>DOI: 10.1007/s10787-024-01543-7</identifier><identifier>PMID: 39126570</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Allergology ; Animals ; Arthralgia - drug therapy ; Biomedical and Life Sciences ; Biomedicine ; Dermatology ; Dietary Supplements ; Euphausiacea ; Gastroenterology ; Humans ; Immunology ; Knee Joint - drug effects ; Oils - administration & dosage ; Oils - pharmacology ; Pharmacology/Toxicology ; Randomized Controlled Trials as Topic ; Review ; Rheumatology</subject><ispartof>Inflammopharmacology, 2024-10, Vol.32 (5), p.3109-3118</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-66c1658c8b34f1ae219b17cc5c3e4ad40537944795ab49dbc987dea2d04def133</cites><orcidid>0009-0000-1913-9465 ; 0009-0001-6544-8450 ; 0000-0003-1484-4581 ; 0000-0002-1127-9495 ; 0000-0002-4146-2098 ; 0000-0001-7545-1111 ; 0009-0001-0265-4919</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10787-024-01543-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10787-024-01543-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39126570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pimentel, Túlio</creatorcontrib><creatorcontrib>Queiroz, Ivo</creatorcontrib><creatorcontrib>Florêncio de Mesquita, Cynthia</creatorcontrib><creatorcontrib>Gallo Ruelas, Mariano</creatorcontrib><creatorcontrib>Leandro, Giovanna N.</creatorcontrib><creatorcontrib>Ribeiro Monteiro, Arthur</creatorcontrib><creatorcontrib>Nunes Pimentel, Fernando</creatorcontrib><title>Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials</title><title>Inflammopharmacology</title><addtitle>Inflammopharmacol</addtitle><addtitle>Inflammopharmacology</addtitle><description>Introduction
Knee pain is a major cause of disability worldwide, particularly among the elderly. Current treatments, including nonsteroidal anti-inflammatory drugs and analgesics, often lead to adverse effects. Krill oil is being explored as a potential alternative, however its efficacy in managing knee symptoms remains unclear.
Methods
MEDLINE, Embase, and Cochrane databases were searched until May 2024 for studies comparing krill oil and placebo in knee pain patients. Endpoints included knee pain, stiffness, physical function, and lipid profiles (HDL-C, LDL-C, triglycerides, and total cholesterol). A restricted maximum likelihood random-effects model with standardized mean differences (SMD) and 95% confidence intervals (CI) was used. A trial sequential analysis was conducted to evaluate further research implications.
Results
We included five trials with 700 patients using krill oil for knee pain. Results showed no significant difference between krill oil and placebo for knee pain, knee stiffness, and lipid profiles. However, krill oil demonstrated a significant small effect in improving knee physical function (SMD -0.24, 95% CI [-0.41; -0.08], I
2
= 0%).Trial sequential analysis provided certainty that krill oil enhances knee physical function compared to placebo and indicated no improvement in knee pain, but the findings for knee stiffness need to be confirmed by further research.
Conclusion
This study found that krill oil supplementation did not significantly improve knee pain, stiffness, or lipid profile, although it may help knee physical function. Based on these findings, krill oil supplementation is not yet justified for knee pain.</description><subject>Allergology</subject><subject>Animals</subject><subject>Arthralgia - drug therapy</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Dermatology</subject><subject>Dietary Supplements</subject><subject>Euphausiacea</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Knee Joint - drug effects</subject><subject>Oils - administration & dosage</subject><subject>Oils - pharmacology</subject><subject>Pharmacology/Toxicology</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Review</subject><subject>Rheumatology</subject><issn>0925-4692</issn><issn>1568-5608</issn><issn>1568-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uclu1TAUtRCIPlp-gAXykk2K54EdqsogKrFp15bj3IBLYgc7afX4B_65bl_pktU90hl0dQ5Cbyg5pYTo95USbXRHmOgIlYJ3-hnaUalMJxUxz9GOWCY7oSw7Qq9qvSaEKK3sS3TELWVKarJDf7-VOE04xwnXbVkmmCGtfo054TEX_CsB4MXH9AF7XPd1hbmRARe4iXCLfRrwDKvvfPLTvsaKb-P6E68l-pYHv7cWdg-f6Dzi0kx5jn9gwCGnteRpavDBUk_Qi7EdeP14j9HVp_PLsy_dxffPX88-XnSBMbN2SgWqpAmm52KkHhi1PdUhyMBB-EEQybUVQlvpe2GHPlijB_BsIGKAkXJ-jN4dcpeS25N1dXOsAabJJ8hbdZy0gowx1jQpO0hDybUWGN1S4uzL3lHi7mdwhxlcm8E9zOB0M719zN_6GYYny7_em4AfBLVR6QcUd5230lqq_4u9A5MclrY</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Pimentel, Túlio</creator><creator>Queiroz, Ivo</creator><creator>Florêncio de Mesquita, Cynthia</creator><creator>Gallo Ruelas, Mariano</creator><creator>Leandro, Giovanna N.</creator><creator>Ribeiro Monteiro, Arthur</creator><creator>Nunes Pimentel, Fernando</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0000-1913-9465</orcidid><orcidid>https://orcid.org/0009-0001-6544-8450</orcidid><orcidid>https://orcid.org/0000-0003-1484-4581</orcidid><orcidid>https://orcid.org/0000-0002-1127-9495</orcidid><orcidid>https://orcid.org/0000-0002-4146-2098</orcidid><orcidid>https://orcid.org/0000-0001-7545-1111</orcidid><orcidid>https://orcid.org/0009-0001-0265-4919</orcidid></search><sort><creationdate>20241001</creationdate><title>Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials</title><author>Pimentel, Túlio ; Queiroz, Ivo ; Florêncio de Mesquita, Cynthia ; Gallo Ruelas, Mariano ; Leandro, Giovanna N. ; Ribeiro Monteiro, Arthur ; Nunes Pimentel, Fernando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-66c1658c8b34f1ae219b17cc5c3e4ad40537944795ab49dbc987dea2d04def133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Allergology</topic><topic>Animals</topic><topic>Arthralgia - drug therapy</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Dermatology</topic><topic>Dietary Supplements</topic><topic>Euphausiacea</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Immunology</topic><topic>Knee Joint - drug effects</topic><topic>Oils - administration & dosage</topic><topic>Oils - pharmacology</topic><topic>Pharmacology/Toxicology</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Review</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pimentel, Túlio</creatorcontrib><creatorcontrib>Queiroz, Ivo</creatorcontrib><creatorcontrib>Florêncio de Mesquita, Cynthia</creatorcontrib><creatorcontrib>Gallo Ruelas, Mariano</creatorcontrib><creatorcontrib>Leandro, Giovanna N.</creatorcontrib><creatorcontrib>Ribeiro Monteiro, Arthur</creatorcontrib><creatorcontrib>Nunes Pimentel, Fernando</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pimentel, Túlio</au><au>Queiroz, Ivo</au><au>Florêncio de Mesquita, Cynthia</au><au>Gallo Ruelas, Mariano</au><au>Leandro, Giovanna N.</au><au>Ribeiro Monteiro, Arthur</au><au>Nunes Pimentel, Fernando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials</atitle><jtitle>Inflammopharmacology</jtitle><stitle>Inflammopharmacol</stitle><addtitle>Inflammopharmacology</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>32</volume><issue>5</issue><spage>3109</spage><epage>3118</epage><pages>3109-3118</pages><issn>0925-4692</issn><issn>1568-5608</issn><eissn>1568-5608</eissn><abstract>Introduction
Knee pain is a major cause of disability worldwide, particularly among the elderly. Current treatments, including nonsteroidal anti-inflammatory drugs and analgesics, often lead to adverse effects. Krill oil is being explored as a potential alternative, however its efficacy in managing knee symptoms remains unclear.
Methods
MEDLINE, Embase, and Cochrane databases were searched until May 2024 for studies comparing krill oil and placebo in knee pain patients. Endpoints included knee pain, stiffness, physical function, and lipid profiles (HDL-C, LDL-C, triglycerides, and total cholesterol). A restricted maximum likelihood random-effects model with standardized mean differences (SMD) and 95% confidence intervals (CI) was used. A trial sequential analysis was conducted to evaluate further research implications.
Results
We included five trials with 700 patients using krill oil for knee pain. Results showed no significant difference between krill oil and placebo for knee pain, knee stiffness, and lipid profiles. However, krill oil demonstrated a significant small effect in improving knee physical function (SMD -0.24, 95% CI [-0.41; -0.08], I
2
= 0%).Trial sequential analysis provided certainty that krill oil enhances knee physical function compared to placebo and indicated no improvement in knee pain, but the findings for knee stiffness need to be confirmed by further research.
Conclusion
This study found that krill oil supplementation did not significantly improve knee pain, stiffness, or lipid profile, although it may help knee physical function. Based on these findings, krill oil supplementation is not yet justified for knee pain.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>39126570</pmid><doi>10.1007/s10787-024-01543-7</doi><tpages>10</tpages><orcidid>https://orcid.org/0009-0000-1913-9465</orcidid><orcidid>https://orcid.org/0009-0001-6544-8450</orcidid><orcidid>https://orcid.org/0000-0003-1484-4581</orcidid><orcidid>https://orcid.org/0000-0002-1127-9495</orcidid><orcidid>https://orcid.org/0000-0002-4146-2098</orcidid><orcidid>https://orcid.org/0000-0001-7545-1111</orcidid><orcidid>https://orcid.org/0009-0001-0265-4919</orcidid></addata></record> |
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| subjects | Allergology Animals Arthralgia - drug therapy Biomedical and Life Sciences Biomedicine Dermatology Dietary Supplements Euphausiacea Gastroenterology Humans Immunology Knee Joint - drug effects Oils - administration & dosage Oils - pharmacology Pharmacology/Toxicology Randomized Controlled Trials as Topic Review Rheumatology |
| title | Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials |
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