The potential therapeutic role of IL-35 in pathophysiological processes in type 1 diabetes mellitus

[Display omitted] •T1DM has characteristics marked with a gradual immune-mediated deterioration of the β-cells producing insulin.•IL-35 has potential role as an effective autoimmune inhibitor and has potential therapeutic value in T1DM clinical trials.•Administration of IL-35, could block effector T...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2024-10, Vol.182, p.156732, Article 156732
Hauptverfasser:	Bakery, Heba H., Hussein, Heba A.A., Ahmed, Osama M., Abuelsaad, Abdelaziz S.A., Khalil, Rehab G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animals B-Lymphocytes, Regulatory - immunology B-Lymphocytes, Regulatory - metabolism Child Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - metabolism Humans IL-35 Inflammation - immunology Inflammation - metabolism Interleukin-10 - metabolism Interleukins - metabolism Possible mechanisms T-Lymphocytes, Regulatory - immunology T1DM Therapeutic role of IL-35 Transforming Growth Factor beta - metabolism Treg cells
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