Overexpression of miR-199b-5p in Colony Forming Unit-Hill's Colonies Positively Mediates the Inflammatory Response in Subclinical Cardiovascular Disease Model: Metformin Therapy Attenuates Its Expression

Well-controlled type 1 diabetes (T1DM) is characterized by inflammation and endothelial dysfunction, thus constituting a suitable model of subclinical cardiovascular disease (CVD). miR-199b-5p overexpression in murine CVD has shown proatherosclerotic effects. We hypothesized that miR-199b-5p would b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2024-08, Vol.25 (15), p.8087
Hauptverfasser:	Bakhashab, Sherin, Barber, Rosie, O'Neill, Josie, Arden, Catherine, Weaver, Jolanta U
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antidiabetics Atherosclerosis Biomarkers C-Reactive Protein - genetics C-Reactive Protein - metabolism Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - drug therapy Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Case-Control Studies Diabetes Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetes therapy Endothelium Female Females Gene Expression Regulation - drug effects Humans Hyperglycemia Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - metabolism Insulin-like growth factors Jagged-1 Protein - genetics Jagged-1 Protein - metabolism Kinases Male Metabolism Metformin Metformin - pharmacology Metformin - therapeutic use MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Mortality Pathogenesis RNA polymerase Sirtuin 1 - genetics Sirtuin 1 - metabolism STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Trends Tumor necrosis factor-TNF Type 1 diabetes Vascular endothelial growth factor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!