Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer
Peroxiporins are a specialized subset of aquaporins, which are integral membrane proteins primarily known for facilitating water transport across cell membranes. In addition to the classical water transport function, peroxiporins have the unique capability to transport hydrogen peroxide (H O ), a re...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2024-08, Vol.25 (15), p.8381 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 15 |
| container_start_page | 8381 |
| container_title | International journal of molecular sciences |
| container_volume | 25 |
| creator | da Silva, Inês V Mlinarić, Monika Lourenço, Ana Rita Pérez-Garcia, Olivia Čipak Gašparović, Ana Soveral, Graça |
| description | Peroxiporins are a specialized subset of aquaporins, which are integral membrane proteins primarily known for facilitating water transport across cell membranes. In addition to the classical water transport function, peroxiporins have the unique capability to transport hydrogen peroxide (H
O
), a reactive oxygen species involved in various cellular signaling pathways and regulation of oxidative stress responses. The regulation of H
O
levels is crucial for maintaining cellular homeostasis, and peroxiporins play a significant role in this process by modulating its intracellular and extracellular concentrations. This ability to facilitate the passage of H
O
positions peroxiporins as key players in redox biology and cellular signaling, with implications for understanding and treating various diseases linked to oxidative stress and inflammation. This review provides updated information on the physiological roles of peroxiporins and their implications in disease, emphasizing their potential as novel biomarkers and drug targets in conditions where they are dysregulated, such as inflammation and cancer. |
| doi_str_mv | 10.3390/ijms25158381 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_3091287087</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A804511655</galeid><sourcerecordid>A804511655</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-af3072ee66285aa9b72a180b77da699b5244ef08f3eb785e0c60bf975ae1d98e3</originalsourceid><addsrcrecordid>eNptkUtLAzEUhYMoPqo71zLgxoXVPJpJ4q4UXyC04GM7ZGZuSupMUpOp1H9v6luRu7iH8J3LCQehfYJPGFP41M7aSDnhkkmyhrbJgNI-xrlY_6G30E6MM4wpo1xtoi2mSBKcbqOHCQS_tHMfrIuZdnU2Xtpad_YZstsuQIxn2ST41kbrptmdDlPoYtb5JKvHBrJrZxrdtsng3Zt9pF0FYRdtGN1E2PvYPXR_cX43uurfjC-vR8ObfsUI6fraMCwoQJ5TybVWpaCaSFwKUetcqZLTwQAMloZBKSQHXOW4NEpwDaRWElgPHb3fnQf_tIDYFSlpBU2jHfhFLBhOP5UCS5HQwz_ozC-CS-lWFFaMc8a-qaluoLDO-C7oanW0GEo84ITkieuhk3-oNDW0tvIOjE3vvwzH74Yq-BgDmGIebKvDS0Fwsaqx-Fljwg8-si7KFuov-LM39gr-7ZZT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3090935533</pqid></control><display><type>article</type><title>Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>da Silva, Inês V ; Mlinarić, Monika ; Lourenço, Ana Rita ; Pérez-Garcia, Olivia ; Čipak Gašparović, Ana ; Soveral, Graça</creator><creatorcontrib>da Silva, Inês V ; Mlinarić, Monika ; Lourenço, Ana Rita ; Pérez-Garcia, Olivia ; Čipak Gašparović, Ana ; Soveral, Graça</creatorcontrib><description>Peroxiporins are a specialized subset of aquaporins, which are integral membrane proteins primarily known for facilitating water transport across cell membranes. In addition to the classical water transport function, peroxiporins have the unique capability to transport hydrogen peroxide (H
O
), a reactive oxygen species involved in various cellular signaling pathways and regulation of oxidative stress responses. The regulation of H
O
levels is crucial for maintaining cellular homeostasis, and peroxiporins play a significant role in this process by modulating its intracellular and extracellular concentrations. This ability to facilitate the passage of H
O
positions peroxiporins as key players in redox biology and cellular signaling, with implications for understanding and treating various diseases linked to oxidative stress and inflammation. This review provides updated information on the physiological roles of peroxiporins and their implications in disease, emphasizing their potential as novel biomarkers and drug targets in conditions where they are dysregulated, such as inflammation and cancer.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25158381</identifier><identifier>PMID: 39125952</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Aquaporins ; Aquaporins - metabolism ; Cancer ; Cancer therapies ; Cell growth ; Defense mechanisms ; Development and progression ; Endoplasmic reticulum ; Glycerol ; Humans ; Hydrogen bonds ; Hydrogen Peroxide - metabolism ; Inflammation ; Inflammation - metabolism ; Kinases ; Membranes ; Mutation ; Neoplasms - metabolism ; Oxidation-Reduction ; Oxidative Stress ; Permeability ; Physiological aspects ; Protein folding ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Signal Transduction ; Type 2 diabetes</subject><ispartof>International journal of molecular sciences, 2024-08, Vol.25 (15), p.8381</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-af3072ee66285aa9b72a180b77da699b5244ef08f3eb785e0c60bf975ae1d98e3</cites><orcidid>0000-0001-8487-110X ; 0000-0002-2916-4848 ; 0000-0003-2222-7559 ; 0000-0003-2000-8950</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39125952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Silva, Inês V</creatorcontrib><creatorcontrib>Mlinarić, Monika</creatorcontrib><creatorcontrib>Lourenço, Ana Rita</creatorcontrib><creatorcontrib>Pérez-Garcia, Olivia</creatorcontrib><creatorcontrib>Čipak Gašparović, Ana</creatorcontrib><creatorcontrib>Soveral, Graça</creatorcontrib><title>Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Peroxiporins are a specialized subset of aquaporins, which are integral membrane proteins primarily known for facilitating water transport across cell membranes. In addition to the classical water transport function, peroxiporins have the unique capability to transport hydrogen peroxide (H
O
), a reactive oxygen species involved in various cellular signaling pathways and regulation of oxidative stress responses. The regulation of H
O
levels is crucial for maintaining cellular homeostasis, and peroxiporins play a significant role in this process by modulating its intracellular and extracellular concentrations. This ability to facilitate the passage of H
O
positions peroxiporins as key players in redox biology and cellular signaling, with implications for understanding and treating various diseases linked to oxidative stress and inflammation. This review provides updated information on the physiological roles of peroxiporins and their implications in disease, emphasizing their potential as novel biomarkers and drug targets in conditions where they are dysregulated, such as inflammation and cancer.</description><subject>Animals</subject><subject>Aquaporins</subject><subject>Aquaporins - metabolism</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cell growth</subject><subject>Defense mechanisms</subject><subject>Development and progression</subject><subject>Endoplasmic reticulum</subject><subject>Glycerol</subject><subject>Humans</subject><subject>Hydrogen bonds</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Inflammation</subject><subject>Inflammation - metabolism</subject><subject>Kinases</subject><subject>Membranes</subject><subject>Mutation</subject><subject>Neoplasms - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Permeability</subject><subject>Physiological aspects</subject><subject>Protein folding</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Signal Transduction</subject><subject>Type 2 diabetes</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkUtLAzEUhYMoPqo71zLgxoXVPJpJ4q4UXyC04GM7ZGZuSupMUpOp1H9v6luRu7iH8J3LCQehfYJPGFP41M7aSDnhkkmyhrbJgNI-xrlY_6G30E6MM4wpo1xtoi2mSBKcbqOHCQS_tHMfrIuZdnU2Xtpad_YZstsuQIxn2ST41kbrptmdDlPoYtb5JKvHBrJrZxrdtsng3Zt9pF0FYRdtGN1E2PvYPXR_cX43uurfjC-vR8ObfsUI6fraMCwoQJ5TybVWpaCaSFwKUetcqZLTwQAMloZBKSQHXOW4NEpwDaRWElgPHb3fnQf_tIDYFSlpBU2jHfhFLBhOP5UCS5HQwz_ozC-CS-lWFFaMc8a-qaluoLDO-C7oanW0GEo84ITkieuhk3-oNDW0tvIOjE3vvwzH74Yq-BgDmGIebKvDS0Fwsaqx-Fljwg8-si7KFuov-LM39gr-7ZZT</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>da Silva, Inês V</creator><creator>Mlinarić, Monika</creator><creator>Lourenço, Ana Rita</creator><creator>Pérez-Garcia, Olivia</creator><creator>Čipak Gašparović, Ana</creator><creator>Soveral, Graça</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8487-110X</orcidid><orcidid>https://orcid.org/0000-0002-2916-4848</orcidid><orcidid>https://orcid.org/0000-0003-2222-7559</orcidid><orcidid>https://orcid.org/0000-0003-2000-8950</orcidid></search><sort><creationdate>20240801</creationdate><title>Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer</title><author>da Silva, Inês V ; Mlinarić, Monika ; Lourenço, Ana Rita ; Pérez-Garcia, Olivia ; Čipak Gašparović, Ana ; Soveral, Graça</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-af3072ee66285aa9b72a180b77da699b5244ef08f3eb785e0c60bf975ae1d98e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Aquaporins</topic><topic>Aquaporins - metabolism</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Cell growth</topic><topic>Defense mechanisms</topic><topic>Development and progression</topic><topic>Endoplasmic reticulum</topic><topic>Glycerol</topic><topic>Humans</topic><topic>Hydrogen bonds</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>Inflammation</topic><topic>Inflammation - metabolism</topic><topic>Kinases</topic><topic>Membranes</topic><topic>Mutation</topic><topic>Neoplasms - metabolism</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>Permeability</topic><topic>Physiological aspects</topic><topic>Protein folding</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Signal Transduction</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Silva, Inês V</creatorcontrib><creatorcontrib>Mlinarić, Monika</creatorcontrib><creatorcontrib>Lourenço, Ana Rita</creatorcontrib><creatorcontrib>Pérez-Garcia, Olivia</creatorcontrib><creatorcontrib>Čipak Gašparović, Ana</creatorcontrib><creatorcontrib>Soveral, Graça</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Silva, Inês V</au><au>Mlinarić, Monika</au><au>Lourenço, Ana Rita</au><au>Pérez-Garcia, Olivia</au><au>Čipak Gašparović, Ana</au><au>Soveral, Graça</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>25</volume><issue>15</issue><spage>8381</spage><pages>8381-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Peroxiporins are a specialized subset of aquaporins, which are integral membrane proteins primarily known for facilitating water transport across cell membranes. In addition to the classical water transport function, peroxiporins have the unique capability to transport hydrogen peroxide (H
O
), a reactive oxygen species involved in various cellular signaling pathways and regulation of oxidative stress responses. The regulation of H
O
levels is crucial for maintaining cellular homeostasis, and peroxiporins play a significant role in this process by modulating its intracellular and extracellular concentrations. This ability to facilitate the passage of H
O
positions peroxiporins as key players in redox biology and cellular signaling, with implications for understanding and treating various diseases linked to oxidative stress and inflammation. This review provides updated information on the physiological roles of peroxiporins and their implications in disease, emphasizing their potential as novel biomarkers and drug targets in conditions where they are dysregulated, such as inflammation and cancer.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39125952</pmid><doi>10.3390/ijms25158381</doi><orcidid>https://orcid.org/0000-0001-8487-110X</orcidid><orcidid>https://orcid.org/0000-0002-2916-4848</orcidid><orcidid>https://orcid.org/0000-0003-2222-7559</orcidid><orcidid>https://orcid.org/0000-0003-2000-8950</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2024-08, Vol.25 (15), p.8381 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3091287087 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Animals Aquaporins Aquaporins - metabolism Cancer Cancer therapies Cell growth Defense mechanisms Development and progression Endoplasmic reticulum Glycerol Humans Hydrogen bonds Hydrogen Peroxide - metabolism Inflammation Inflammation - metabolism Kinases Membranes Mutation Neoplasms - metabolism Oxidation-Reduction Oxidative Stress Permeability Physiological aspects Protein folding Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction Type 2 diabetes |
| title | Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T20%3A44%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Peroxiporins%20and%20Oxidative%20Stress:%20Promising%20Targets%20to%20Tackle%20Inflammation%20and%20Cancer&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=da%20Silva,%20In%C3%AAs%20V&rft.date=2024-08-01&rft.volume=25&rft.issue=15&rft.spage=8381&rft.pages=8381-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms25158381&rft_dat=%3Cgale_proqu%3EA804511655%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3090935533&rft_id=info:pmid/39125952&rft_galeid=A804511655&rfr_iscdi=true |