From Proteome to Potential Drugs: Integration of Subtractive Proteomics and Ensemble Docking for Drug Repurposing against Pseudomonas aeruginosa RND Superfamily Proteins

( ) poses a significant threat as a nosocomial pathogen due to its robust resistance mechanisms and virulence factors. This study integrates subtractive proteomics and ensemble docking to identify and characterize essential proteins in , aiming to discover therapeutic targets and repurpose commercia...

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Veröffentlicht in:	International journal of molecular sciences 2024-08, Vol.25 (15), p.8027
Hauptverfasser:	Urra, Gabriela, Valdés-Muñoz, Elizabeth, Suardiaz, Reynier, Hernández-Rodríguez, Erix W, Palma, Jonathan M, Ríos-Rozas, Sofía E, Flores-Morales, Camila A, Alegría-Arcos, Melissa, Yáñez, Osvaldo, Morales-Quintana, Luis, D'Afonseca, Vívian, Bustos, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry Bacterial Proteins - metabolism Datasets Drug Repositioning Drug resistance Drug resistance in microorganisms Health aspects Humans Infection Kinases Methicillin Molecular Docking Simulation Nosocomial infections Proteins Proteome - metabolism Proteomics Proteomics - methods Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - metabolism Salmonella Suramin - chemistry Suramin - pharmacology Suramin sodium Tetracycline Tetracyclines Toxicity Virulence
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