Overexpression of RPOTmp Being Targeted to Either Mitochondria or Chloroplasts in Arabidopsis Leads to Overall Transcriptome Changes and Faster Growth
The transcription of organellar genes is performed by three nuclear-encoded RNA polymerases: RPOTm, RPOTmp, and RPOTp. The RPOTmp protein possesses ambiguous transit peptides, allowing participation in gene expression control in both mitochondria and chloroplasts, although its function in plastids i...
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| Veröffentlicht in: | International journal of molecular sciences 2024-08, Vol.25 (15), p.8164 |
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| creator | Gorbenko, Igor V Tarasenko, Vladislav I Garnik, Elena Y Yakovleva, Tatiana V Katyshev, Alexander I Belkov, Vadim I Orlov, Yuriy L Konstantinov, Yuri M Koulintchenko, Milana V |
| description | The transcription of
organellar genes is performed by three nuclear-encoded RNA polymerases: RPOTm, RPOTmp, and RPOTp. The RPOTmp protein possesses ambiguous transit peptides, allowing participation in gene expression control in both mitochondria and chloroplasts, although its function in plastids is still under discussion. Here, we show that the overexpression of RPOTmp in
, targeted either to mitochondria or chloroplasts, disturbs the dormant seed state, and it causes the following effects: earlier germination, decreased ABA sensitivity, faster seedling growth, and earlier flowering. The germination of RPOTmp overexpressors is less sensitive to NaCl, while
knockout is highly vulnerable to salt stress. We found that mitochondrial dysfunction in the
mutant induces an unknown retrograde response pathway that bypasses AOX and ANAC017. Here, we show that RPOTmp transcribes the
,
, and
genes in plastids and up to 22 genes in mitochondria. |
| doi_str_mv | 10.3390/ijms25158164 |
| format | Article |
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organellar genes is performed by three nuclear-encoded RNA polymerases: RPOTm, RPOTmp, and RPOTp. The RPOTmp protein possesses ambiguous transit peptides, allowing participation in gene expression control in both mitochondria and chloroplasts, although its function in plastids is still under discussion. Here, we show that the overexpression of RPOTmp in
, targeted either to mitochondria or chloroplasts, disturbs the dormant seed state, and it causes the following effects: earlier germination, decreased ABA sensitivity, faster seedling growth, and earlier flowering. The germination of RPOTmp overexpressors is less sensitive to NaCl, while
knockout is highly vulnerable to salt stress. We found that mitochondrial dysfunction in the
mutant induces an unknown retrograde response pathway that bypasses AOX and ANAC017. Here, we show that RPOTmp transcribes the
,
, and
genes in plastids and up to 22 genes in mitochondria.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25158164</identifier><identifier>PMID: 39125738</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Arabidopsis - genetics ; Arabidopsis - growth & development ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Arabidopsis thaliana ; Chloroplasts ; Chloroplasts - genetics ; Chloroplasts - metabolism ; DNA-Directed RNA Polymerases - genetics ; DNA-Directed RNA Polymerases - metabolism ; Gene expression ; Gene Expression Regulation, Plant ; Genes ; Genetic engineering ; Genomes ; Germination - genetics ; Instrument industry ; International economic relations ; Metabolism ; Metabolites ; Mitochondria ; Mitochondria - genetics ; Mitochondria - metabolism ; Mitochondrial DNA ; Plant growth ; Plants, Genetically Modified - genetics ; Plants, Genetically Modified - growth & development ; Plastids ; Proteins ; RNA polymerase ; Seedlings - genetics ; Seedlings - growth & development ; Seeds ; Transcription factors ; Transcriptome ; Transfer RNA</subject><ispartof>International journal of molecular sciences, 2024-08, Vol.25 (15), p.8164</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c283t-32b2fcc4fcd467ce4e87c7bd621d466737d14e40bdf24b433c9d0dad7ae2a17a3</cites><orcidid>0000-0002-7096-7159 ; 0000-0002-0601-2788 ; 0000-0003-0931-2863 ; 0000-0001-7856-0460 ; 0000-0003-0587-1609</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39125738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorbenko, Igor V</creatorcontrib><creatorcontrib>Tarasenko, Vladislav I</creatorcontrib><creatorcontrib>Garnik, Elena Y</creatorcontrib><creatorcontrib>Yakovleva, Tatiana V</creatorcontrib><creatorcontrib>Katyshev, Alexander I</creatorcontrib><creatorcontrib>Belkov, Vadim I</creatorcontrib><creatorcontrib>Orlov, Yuriy L</creatorcontrib><creatorcontrib>Konstantinov, Yuri M</creatorcontrib><creatorcontrib>Koulintchenko, Milana V</creatorcontrib><title>Overexpression of RPOTmp Being Targeted to Either Mitochondria or Chloroplasts in Arabidopsis Leads to Overall Transcriptome Changes and Faster Growth</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The transcription of
organellar genes is performed by three nuclear-encoded RNA polymerases: RPOTm, RPOTmp, and RPOTp. The RPOTmp protein possesses ambiguous transit peptides, allowing participation in gene expression control in both mitochondria and chloroplasts, although its function in plastids is still under discussion. Here, we show that the overexpression of RPOTmp in
, targeted either to mitochondria or chloroplasts, disturbs the dormant seed state, and it causes the following effects: earlier germination, decreased ABA sensitivity, faster seedling growth, and earlier flowering. The germination of RPOTmp overexpressors is less sensitive to NaCl, while
knockout is highly vulnerable to salt stress. We found that mitochondrial dysfunction in the
mutant induces an unknown retrograde response pathway that bypasses AOX and ANAC017. Here, we show that RPOTmp transcribes the
,
, and
genes in plastids and up to 22 genes in mitochondria.</description><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - growth & development</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Arabidopsis thaliana</subject><subject>Chloroplasts</subject><subject>Chloroplasts - genetics</subject><subject>Chloroplasts - metabolism</subject><subject>DNA-Directed RNA Polymerases - genetics</subject><subject>DNA-Directed RNA Polymerases - metabolism</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Plant</subject><subject>Genes</subject><subject>Genetic engineering</subject><subject>Genomes</subject><subject>Germination - genetics</subject><subject>Instrument industry</subject><subject>International economic relations</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Mitochondria</subject><subject>Mitochondria - genetics</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondrial DNA</subject><subject>Plant growth</subject><subject>Plants, Genetically Modified - 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Academic</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gorbenko, Igor V</au><au>Tarasenko, Vladislav I</au><au>Garnik, Elena Y</au><au>Yakovleva, Tatiana V</au><au>Katyshev, Alexander I</au><au>Belkov, Vadim I</au><au>Orlov, Yuriy L</au><au>Konstantinov, Yuri M</au><au>Koulintchenko, Milana V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of RPOTmp Being Targeted to Either Mitochondria or Chloroplasts in Arabidopsis Leads to Overall Transcriptome Changes and Faster Growth</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>25</volume><issue>15</issue><spage>8164</spage><pages>8164-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>The transcription of
organellar genes is performed by three nuclear-encoded RNA polymerases: RPOTm, RPOTmp, and RPOTp. The RPOTmp protein possesses ambiguous transit peptides, allowing participation in gene expression control in both mitochondria and chloroplasts, although its function in plastids is still under discussion. Here, we show that the overexpression of RPOTmp in
, targeted either to mitochondria or chloroplasts, disturbs the dormant seed state, and it causes the following effects: earlier germination, decreased ABA sensitivity, faster seedling growth, and earlier flowering. The germination of RPOTmp overexpressors is less sensitive to NaCl, while
knockout is highly vulnerable to salt stress. We found that mitochondrial dysfunction in the
mutant induces an unknown retrograde response pathway that bypasses AOX and ANAC017. Here, we show that RPOTmp transcribes the
,
, and
genes in plastids and up to 22 genes in mitochondria.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39125738</pmid><doi>10.3390/ijms25158164</doi><orcidid>https://orcid.org/0000-0002-7096-7159</orcidid><orcidid>https://orcid.org/0000-0002-0601-2788</orcidid><orcidid>https://orcid.org/0000-0003-0931-2863</orcidid><orcidid>https://orcid.org/0000-0001-7856-0460</orcidid><orcidid>https://orcid.org/0000-0003-0587-1609</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Arabidopsis - genetics Arabidopsis - growth & development Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Arabidopsis thaliana Chloroplasts Chloroplasts - genetics Chloroplasts - metabolism DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Gene expression Gene Expression Regulation, Plant Genes Genetic engineering Genomes Germination - genetics Instrument industry International economic relations Metabolism Metabolites Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Plant growth Plants, Genetically Modified - genetics Plants, Genetically Modified - growth & development Plastids Proteins RNA polymerase Seedlings - genetics Seedlings - growth & development Seeds Transcription factors Transcriptome Transfer RNA |
| title | Overexpression of RPOTmp Being Targeted to Either Mitochondria or Chloroplasts in Arabidopsis Leads to Overall Transcriptome Changes and Faster Growth |
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