Role of Interleukin 6 in Acute Pancreatitis: A Possible Marker for Disease Prognosis
Acute pancreatitis (AP) is a significant cause of morbidity, even in children, and is frequently associated with systemic manifestations. There are many cytokines involved in the inflammatory response characteristic of this disease. Interleukin 6 (IL-6) is one of the most important cytokines involve...
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| Veröffentlicht in: | International journal of molecular sciences 2024-08, Vol.25 (15), p.8283 |
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| description | Acute pancreatitis (AP) is a significant cause of morbidity, even in children, and is frequently associated with systemic manifestations. There are many cytokines involved in the inflammatory response characteristic of this disease. Interleukin 6 (IL-6) is one of the most important cytokines involved in AP, beginning from cellular injury and continuing to the systemic inflammatory response and distant organ involvement. IL-6 is a multifunctional cytokine that regulates acute-phase response and inflammation. It is produced by various cells and exerts its biological role on many cells through its high-affinity complex receptor. IL-6 has been investigated as a predicting maker for severe forms of AP. Many studies have validated the use of IL-6 serum levels in the first 48 h as a reliable marker for severe evolution and multisystemic involvement. Still, it has not been used in daily practice until now. This review discusses the main binding mechanisms by which IL-6 triggers cellular response and the AP pathogenetic mechanisms in which IL-6 is involved. We then emphasize the promising role of IL-6 as a prognostic marker, which could be added as a routine marker at admission in children with AP. |
| doi_str_mv | 10.3390/ijms25158283 |
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There are many cytokines involved in the inflammatory response characteristic of this disease. Interleukin 6 (IL-6) is one of the most important cytokines involved in AP, beginning from cellular injury and continuing to the systemic inflammatory response and distant organ involvement. IL-6 is a multifunctional cytokine that regulates acute-phase response and inflammation. It is produced by various cells and exerts its biological role on many cells through its high-affinity complex receptor. IL-6 has been investigated as a predicting maker for severe forms of AP. Many studies have validated the use of IL-6 serum levels in the first 48 h as a reliable marker for severe evolution and multisystemic involvement. Still, it has not been used in daily practice until now. This review discusses the main binding mechanisms by which IL-6 triggers cellular response and the AP pathogenetic mechanisms in which IL-6 is involved. We then emphasize the promising role of IL-6 as a prognostic marker, which could be added as a routine marker at admission in children with AP.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25158283</identifier><identifier>PMID: 39125854</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acute Disease ; Animals ; Apoptosis ; B cells ; Biomarkers - blood ; Cytokines ; Humans ; Infections ; Inflammation ; Interleukin-6 - blood ; Interleukin-6 - metabolism ; Interleukins ; Kinases ; Ligands ; Liver ; Multiple organ dysfunction syndrome ; Neutrophils ; Pancreatitis ; Pancreatitis - blood ; Pancreatitis - diagnosis ; Pancreatitis - metabolism ; Pathogenesis ; Prognosis ; Protein synthesis ; Proteins ; Signal transduction ; Tumor necrosis factor-TNF</subject><ispartof>International journal of molecular sciences, 2024-08, Vol.25 (15), p.8283</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Acute Disease Animals Apoptosis B cells Biomarkers - blood Cytokines Humans Infections Inflammation Interleukin-6 - blood Interleukin-6 - metabolism Interleukins Kinases Ligands Liver Multiple organ dysfunction syndrome Neutrophils Pancreatitis Pancreatitis - blood Pancreatitis - diagnosis Pancreatitis - metabolism Pathogenesis Prognosis Protein synthesis Proteins Signal transduction Tumor necrosis factor-TNF |
| title | Role of Interleukin 6 in Acute Pancreatitis: A Possible Marker for Disease Prognosis |
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