Preclinical assessment for translation to humans: The PATH approach for assessing supporting evidence for early-phase trials and innovative care

Early-phase trials and innovative care draw support from basic science, preclinical studies, and clinical research. Such evidential diversity presents a challenge for traditional ways of synthesizing evidence. In what follows, we review the limitations of existing approaches for communicating suppor...

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Veröffentlicht in:	Med (New York, N.Y. : Online) N.Y. : Online), 2024-10, Vol.5 (10), p.1227-1236
Hauptverfasser:	Kimmelman, Jonathan, Bodilly Kane, Patrick, Bicer, Selin, Carlisle, Benjamin Gregory
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clinical Trials as Topic - methods Drug Evaluation, Preclinical - methods Evidence-Based Medicine - methods Humans Translational Research, Biomedical - methods
Online-Zugang:	Volltext
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