Combined mediterranean diet-based sustainable healthy diet and multicomponent training intervention impact on plasma biomarkers and metabolome in older adults
Healthy dietary patterns and exercise practices have been associated with improved metabolic and inflammatory profiles. However, studies regarding the combined effect of these interventions on plasma biomarkers and metabolome in older adults are sparser. The primary aim of this study was to investig...
Gespeichert in:
| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2024-09, Vol.43 (9), p.2125-2135 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2135 |
|---|---|
| container_issue | 9 |
| container_start_page | 2125 |
| container_title | Clinical nutrition (Edinburgh, Scotland) |
| container_volume | 43 |
| creator | Sampaio, Joana Pinto, Joana Pizarro, Andreia Oliveira, Bruno Moreira, André Padrão, Patrícia Moreira, Pedro Guedes de Pinho, Paula Carvalho, Joana Barros, Renata |
| description | Healthy dietary patterns and exercise practices have been associated with improved metabolic and inflammatory profiles. However, studies regarding the combined effect of these interventions on plasma biomarkers and metabolome in older adults are sparser. The primary aim of this study was to investigate the impact of a combined Mediterranean Diet-based Sustainable Healthy Diet (SHD) and Multicomponent Training (MT) intervention on the plasma biomarkers and metabolome and how dietary intake and exercise could modulate these effects.
SHD intervention included a weekly supply of Mediterranean Diet-based SHD food and four nutrition sessions involving a Mediterranean-Diet culinary workshop, and the exercise program included 50-min MT group sessions, held three times a week, lasting both 12 weeks. Plasma biomarkers were obtained through standard biochemical analysis. A proton (1H) nuclear magnetic resonance (NMR) spectroscopy-based metabolomics approach was used to study the metabolome in blood plasma. Repeated measures ANOVA were performed and adjusted for confounders.
SHD + MT intervention significantly decreased HDL-C and calcium. SHD + MT showed some changes in common with the SHD and MT group, namely a significant decrease in citrate levels (p = 0.009 for SHD + MT; p = 0.037 for SHDT) and an increase in pyruvate (p |
| doi_str_mv | 10.1016/j.clnu.2024.07.025 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3090944839</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0261561424002541</els_id><sourcerecordid>3090944839</sourcerecordid><originalsourceid>FETCH-LOGICAL-c308t-ba28dd6f6713a927bfd93a81da750d5c6baf4d89423ceeec0235262acada632f3</originalsourceid><addsrcrecordid>eNp9kcuO1DAQRS0EYpqBH2CBvGST4EfiJBIb1OIljcQG1lbFrjBuHDvYzkjzM3wrbnpgycol171XVXUIeclZyxlXb06t8WFvBRNdy4aWif4ROfBeioZPo3xMDkwo3vSKd1fkWc4nxlgvh_EpuZIT50rx6UB-HeM6u4CWrmhdwZQgIARqHZZmhlwbec8FXIDZI71F8OX2_k-bQqiu3Rdn4rrFgKHQkqrShe_UhZp1V79cDNStG5hCa7V5yCvQ2cUV0g9M-RKCBebo44rVR6O3mCjYmpyfkycL-IwvHt5r8u3D-6_HT83Nl4-fj-9uGiPZeB5UjNaqRQ1cwiSGebGThJFbGHpme6NmWDo7Tp2QBhENE7IXSoABC0qKRV6T15fcLcWfO-aiV5cNel-vEfesJZvY1HWjnKpUXKQmxZwTLnpLrm5zrznTZy76pM9c9JmLZoOuXKrp1UP-PtdD_7P8BVEFby8CrFveOUw6G4fBVCgJTdE2uv_l_waKHqRb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3090944839</pqid></control><display><type>article</type><title>Combined mediterranean diet-based sustainable healthy diet and multicomponent training intervention impact on plasma biomarkers and metabolome in older adults</title><source>Elsevier ScienceDirect Journals</source><creator>Sampaio, Joana ; Pinto, Joana ; Pizarro, Andreia ; Oliveira, Bruno ; Moreira, André ; Padrão, Patrícia ; Moreira, Pedro ; Guedes de Pinho, Paula ; Carvalho, Joana ; Barros, Renata</creator><creatorcontrib>Sampaio, Joana ; Pinto, Joana ; Pizarro, Andreia ; Oliveira, Bruno ; Moreira, André ; Padrão, Patrícia ; Moreira, Pedro ; Guedes de Pinho, Paula ; Carvalho, Joana ; Barros, Renata</creatorcontrib><description>Healthy dietary patterns and exercise practices have been associated with improved metabolic and inflammatory profiles. However, studies regarding the combined effect of these interventions on plasma biomarkers and metabolome in older adults are sparser. The primary aim of this study was to investigate the impact of a combined Mediterranean Diet-based Sustainable Healthy Diet (SHD) and Multicomponent Training (MT) intervention on the plasma biomarkers and metabolome and how dietary intake and exercise could modulate these effects.
SHD intervention included a weekly supply of Mediterranean Diet-based SHD food and four nutrition sessions involving a Mediterranean-Diet culinary workshop, and the exercise program included 50-min MT group sessions, held three times a week, lasting both 12 weeks. Plasma biomarkers were obtained through standard biochemical analysis. A proton (1H) nuclear magnetic resonance (NMR) spectroscopy-based metabolomics approach was used to study the metabolome in blood plasma. Repeated measures ANOVA were performed and adjusted for confounders.
SHD + MT intervention significantly decreased HDL-C and calcium. SHD + MT showed some changes in common with the SHD and MT group, namely a significant decrease in citrate levels (p = 0.009 for SHD + MT; p = 0.037 for SHDT) and an increase in pyruvate (p < 0.001 for MT and SHD + MT). The SHD + MT group also revealed specific changes in the levels of some amino acids (decrease in alanine, glutamine and lysine: p = 0.026; p < 0.001; p = 0.038, respectively). Increases in formate (p = 0.025) and unsaturated lipids (p = 0.011) are consistent with changes in energy and lipoprotein metabolism.
Our data show that a combined lifestyle intervention program, including a Mediterranean Diet-based SHD and MT, could modulate biomarker and metabolome and there seems to be a metabolic path associated to these interventions in older adults. Due to its wide-ranging relevance, it is pertinent to assess to what extent combined SHD and MT can contribute to better clinical profiles.</description><identifier>ISSN: 0261-5614</identifier><identifier>ISSN: 1532-1983</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2024.07.025</identifier><identifier>PMID: 39116619</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Biomarkers ; Mediterranean diet ; Metabolome ; Multicomponent training ; Older adults ; Sustainable healthy diet</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2024-09, Vol.43 (9), p.2125-2135</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c308t-ba28dd6f6713a927bfd93a81da750d5c6baf4d89423ceeec0235262acada632f3</cites><orcidid>0000-0002-7035-7799 ; 0000-0003-3998-6500 ; 0000-0001-9719-8364 ; 0000-0002-3043-1720</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0261561424002541$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39116619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sampaio, Joana</creatorcontrib><creatorcontrib>Pinto, Joana</creatorcontrib><creatorcontrib>Pizarro, Andreia</creatorcontrib><creatorcontrib>Oliveira, Bruno</creatorcontrib><creatorcontrib>Moreira, André</creatorcontrib><creatorcontrib>Padrão, Patrícia</creatorcontrib><creatorcontrib>Moreira, Pedro</creatorcontrib><creatorcontrib>Guedes de Pinho, Paula</creatorcontrib><creatorcontrib>Carvalho, Joana</creatorcontrib><creatorcontrib>Barros, Renata</creatorcontrib><title>Combined mediterranean diet-based sustainable healthy diet and multicomponent training intervention impact on plasma biomarkers and metabolome in older adults</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Healthy dietary patterns and exercise practices have been associated with improved metabolic and inflammatory profiles. However, studies regarding the combined effect of these interventions on plasma biomarkers and metabolome in older adults are sparser. The primary aim of this study was to investigate the impact of a combined Mediterranean Diet-based Sustainable Healthy Diet (SHD) and Multicomponent Training (MT) intervention on the plasma biomarkers and metabolome and how dietary intake and exercise could modulate these effects.
SHD intervention included a weekly supply of Mediterranean Diet-based SHD food and four nutrition sessions involving a Mediterranean-Diet culinary workshop, and the exercise program included 50-min MT group sessions, held three times a week, lasting both 12 weeks. Plasma biomarkers were obtained through standard biochemical analysis. A proton (1H) nuclear magnetic resonance (NMR) spectroscopy-based metabolomics approach was used to study the metabolome in blood plasma. Repeated measures ANOVA were performed and adjusted for confounders.
SHD + MT intervention significantly decreased HDL-C and calcium. SHD + MT showed some changes in common with the SHD and MT group, namely a significant decrease in citrate levels (p = 0.009 for SHD + MT; p = 0.037 for SHDT) and an increase in pyruvate (p < 0.001 for MT and SHD + MT). The SHD + MT group also revealed specific changes in the levels of some amino acids (decrease in alanine, glutamine and lysine: p = 0.026; p < 0.001; p = 0.038, respectively). Increases in formate (p = 0.025) and unsaturated lipids (p = 0.011) are consistent with changes in energy and lipoprotein metabolism.
Our data show that a combined lifestyle intervention program, including a Mediterranean Diet-based SHD and MT, could modulate biomarker and metabolome and there seems to be a metabolic path associated to these interventions in older adults. Due to its wide-ranging relevance, it is pertinent to assess to what extent combined SHD and MT can contribute to better clinical profiles.</description><subject>Biomarkers</subject><subject>Mediterranean diet</subject><subject>Metabolome</subject><subject>Multicomponent training</subject><subject>Older adults</subject><subject>Sustainable healthy diet</subject><issn>0261-5614</issn><issn>1532-1983</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kcuO1DAQRS0EYpqBH2CBvGST4EfiJBIb1OIljcQG1lbFrjBuHDvYzkjzM3wrbnpgycol171XVXUIeclZyxlXb06t8WFvBRNdy4aWif4ROfBeioZPo3xMDkwo3vSKd1fkWc4nxlgvh_EpuZIT50rx6UB-HeM6u4CWrmhdwZQgIARqHZZmhlwbec8FXIDZI71F8OX2_k-bQqiu3Rdn4rrFgKHQkqrShe_UhZp1V79cDNStG5hCa7V5yCvQ2cUV0g9M-RKCBebo44rVR6O3mCjYmpyfkycL-IwvHt5r8u3D-6_HT83Nl4-fj-9uGiPZeB5UjNaqRQ1cwiSGebGThJFbGHpme6NmWDo7Tp2QBhENE7IXSoABC0qKRV6T15fcLcWfO-aiV5cNel-vEfesJZvY1HWjnKpUXKQmxZwTLnpLrm5zrznTZy76pM9c9JmLZoOuXKrp1UP-PtdD_7P8BVEFby8CrFveOUw6G4fBVCgJTdE2uv_l_waKHqRb</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Sampaio, Joana</creator><creator>Pinto, Joana</creator><creator>Pizarro, Andreia</creator><creator>Oliveira, Bruno</creator><creator>Moreira, André</creator><creator>Padrão, Patrícia</creator><creator>Moreira, Pedro</creator><creator>Guedes de Pinho, Paula</creator><creator>Carvalho, Joana</creator><creator>Barros, Renata</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7035-7799</orcidid><orcidid>https://orcid.org/0000-0003-3998-6500</orcidid><orcidid>https://orcid.org/0000-0001-9719-8364</orcidid><orcidid>https://orcid.org/0000-0002-3043-1720</orcidid></search><sort><creationdate>20240901</creationdate><title>Combined mediterranean diet-based sustainable healthy diet and multicomponent training intervention impact on plasma biomarkers and metabolome in older adults</title><author>Sampaio, Joana ; Pinto, Joana ; Pizarro, Andreia ; Oliveira, Bruno ; Moreira, André ; Padrão, Patrícia ; Moreira, Pedro ; Guedes de Pinho, Paula ; Carvalho, Joana ; Barros, Renata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c308t-ba28dd6f6713a927bfd93a81da750d5c6baf4d89423ceeec0235262acada632f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biomarkers</topic><topic>Mediterranean diet</topic><topic>Metabolome</topic><topic>Multicomponent training</topic><topic>Older adults</topic><topic>Sustainable healthy diet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sampaio, Joana</creatorcontrib><creatorcontrib>Pinto, Joana</creatorcontrib><creatorcontrib>Pizarro, Andreia</creatorcontrib><creatorcontrib>Oliveira, Bruno</creatorcontrib><creatorcontrib>Moreira, André</creatorcontrib><creatorcontrib>Padrão, Patrícia</creatorcontrib><creatorcontrib>Moreira, Pedro</creatorcontrib><creatorcontrib>Guedes de Pinho, Paula</creatorcontrib><creatorcontrib>Carvalho, Joana</creatorcontrib><creatorcontrib>Barros, Renata</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sampaio, Joana</au><au>Pinto, Joana</au><au>Pizarro, Andreia</au><au>Oliveira, Bruno</au><au>Moreira, André</au><au>Padrão, Patrícia</au><au>Moreira, Pedro</au><au>Guedes de Pinho, Paula</au><au>Carvalho, Joana</au><au>Barros, Renata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined mediterranean diet-based sustainable healthy diet and multicomponent training intervention impact on plasma biomarkers and metabolome in older adults</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>43</volume><issue>9</issue><spage>2125</spage><epage>2135</epage><pages>2125-2135</pages><issn>0261-5614</issn><issn>1532-1983</issn><eissn>1532-1983</eissn><abstract>Healthy dietary patterns and exercise practices have been associated with improved metabolic and inflammatory profiles. However, studies regarding the combined effect of these interventions on plasma biomarkers and metabolome in older adults are sparser. The primary aim of this study was to investigate the impact of a combined Mediterranean Diet-based Sustainable Healthy Diet (SHD) and Multicomponent Training (MT) intervention on the plasma biomarkers and metabolome and how dietary intake and exercise could modulate these effects.
SHD intervention included a weekly supply of Mediterranean Diet-based SHD food and four nutrition sessions involving a Mediterranean-Diet culinary workshop, and the exercise program included 50-min MT group sessions, held three times a week, lasting both 12 weeks. Plasma biomarkers were obtained through standard biochemical analysis. A proton (1H) nuclear magnetic resonance (NMR) spectroscopy-based metabolomics approach was used to study the metabolome in blood plasma. Repeated measures ANOVA were performed and adjusted for confounders.
SHD + MT intervention significantly decreased HDL-C and calcium. SHD + MT showed some changes in common with the SHD and MT group, namely a significant decrease in citrate levels (p = 0.009 for SHD + MT; p = 0.037 for SHDT) and an increase in pyruvate (p < 0.001 for MT and SHD + MT). The SHD + MT group also revealed specific changes in the levels of some amino acids (decrease in alanine, glutamine and lysine: p = 0.026; p < 0.001; p = 0.038, respectively). Increases in formate (p = 0.025) and unsaturated lipids (p = 0.011) are consistent with changes in energy and lipoprotein metabolism.
Our data show that a combined lifestyle intervention program, including a Mediterranean Diet-based SHD and MT, could modulate biomarker and metabolome and there seems to be a metabolic path associated to these interventions in older adults. Due to its wide-ranging relevance, it is pertinent to assess to what extent combined SHD and MT can contribute to better clinical profiles.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39116619</pmid><doi>10.1016/j.clnu.2024.07.025</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-7035-7799</orcidid><orcidid>https://orcid.org/0000-0003-3998-6500</orcidid><orcidid>https://orcid.org/0000-0001-9719-8364</orcidid><orcidid>https://orcid.org/0000-0002-3043-1720</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0261-5614 |
| ispartof | Clinical nutrition (Edinburgh, Scotland), 2024-09, Vol.43 (9), p.2125-2135 |
| issn | 0261-5614 1532-1983 1532-1983 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3090944839 |
| source | Elsevier ScienceDirect Journals |
| subjects | Biomarkers Mediterranean diet Metabolome Multicomponent training Older adults Sustainable healthy diet |
| title | Combined mediterranean diet-based sustainable healthy diet and multicomponent training intervention impact on plasma biomarkers and metabolome in older adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T15%3A48%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combined%20mediterranean%20diet-based%20sustainable%20healthy%20diet%20and%20multicomponent%20training%20intervention%20impact%20on%20plasma%20biomarkers%20and%20metabolome%20in%20older%20adults&rft.jtitle=Clinical%20nutrition%20(Edinburgh,%20Scotland)&rft.au=Sampaio,%20Joana&rft.date=2024-09-01&rft.volume=43&rft.issue=9&rft.spage=2125&rft.epage=2135&rft.pages=2125-2135&rft.issn=0261-5614&rft.eissn=1532-1983&rft_id=info:doi/10.1016/j.clnu.2024.07.025&rft_dat=%3Cproquest_cross%3E3090944839%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3090944839&rft_id=info:pmid/39116619&rft_els_id=S0261561424002541&rfr_iscdi=true |