Zinc-finger CCHC-type containing protein 8 promotes RNA virus replication by suppressing the type-I interferon responses

Host cells have evolved an intricate regulatory network to fine tune the type-I interferon responses. However, the full picture of this regulatory network remains to be depicted. In this study, we found that knock out of zinc-finger CCHC-type containing protein 8 (ZCCHC8) impairs the replication of...

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Veröffentlicht in:	Journal of virology 2024-09, Vol.98 (9), p.e0079624
Hauptverfasser:	Tu, Shaoyu, Zou, Jiahui, Xiong, Chuhan, Dai, Chao, Sun, Huimin, Luo, Didan, Jin, Meilin, Chen, Huanchun, Zhou, Hongbo
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals CREB-Binding Protein - genetics CREB-Binding Protein - metabolism Encephalitis Virus, Japanese - immunology Encephalitis Virus, Japanese - physiology HEK293 Cells Host-Microbial Interactions Host-Pathogen Interactions Humans Immunity, Innate Influenza A virus - immunology Influenza A virus - physiology Interferon Regulatory Factor-3 - metabolism Interferon Type I - metabolism Pathogenesis and Immunity Phosphorylation RNA Viruses - genetics RNA Viruses - immunology RNA Viruses - physiology Sendai virus - genetics Sendai virus - physiology Signal Transduction Vesiculovirus - physiology Virus Replication
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