The Effect of Low‐Dose Colchicine on the Phenotype and Function of Neutrophils and Monocytes in Patients with Chronic Coronary Artery Disease: A Double‐Blind Randomized Placebo‐Controlled Cross‐Over Study
Recent landmark trials showed that colchicine provides a substantial benefit in reducing major cardiovascular events in patients with coronary artery disease. Yet, its exact mechanism of action is still poorly understood. This study aimed to unravel the effect of colchicine on monocyte and neutrophi...
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| Veröffentlicht in: | Clinical pharmacology and therapeutics 2024-11, Vol.116 (5), p.1325-1333 |
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| creator | Tercan, Helin Broekhoven, Amber Bahrar, Harsh Opstal, Tjerk Cossins, Benjamin C. Rother, Nils Rodwell, Laura Bekkering, Siroon El Messaoudi, Saloua Riksen, Niels P. Cornel, Jan H. |
| description | Recent landmark trials showed that colchicine provides a substantial benefit in reducing major cardiovascular events in patients with coronary artery disease. Yet, its exact mechanism of action is still poorly understood. This study aimed to unravel the effect of colchicine on monocyte and neutrophil phenotype and function. A randomized double‐blind placebo‐controlled cross‐over intervention study was executed in patients with a history of myocardial infarction. In neutrophils, colchicine treatment decreased CD62L expression and NGAL release upon ex vivo stimulation and increased PMA‐induced ROS production. The effects of colchicine on monocytes were limited to a decrease in HLA‐DR expression in the intermediate and nonclassical monocytes. Also, on the level of RNA expression, colchicine did not affect monocyte phenotype, while affecting various immunomodulating genes in neutrophils. Overall, our study suggests that treatment with colchicine affects neutrophil function, particularly by reducing neutrophil recruitment, lowering concentrations of NGAL, and changing the expression of various genes with immunomodulatory potential, whereas the effect on monocytes is limited. |
| doi_str_mv | 10.1002/cpt.3394 |
| format | Article |
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| ispartof | Clinical pharmacology and therapeutics, 2024-11, Vol.116 (5), p.1325-1333 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Chronic Disease Colchicine - administration & dosage Colchicine - pharmacology Coronary Artery Disease - drug therapy Cross-Over Studies Double-Blind Method Female Humans Lipocalin-2 - genetics Lipocalin-2 - metabolism Male Middle Aged Monocytes - drug effects Monocytes - metabolism Neutrophils - drug effects Neutrophils - metabolism Phenotype |
| title | The Effect of Low‐Dose Colchicine on the Phenotype and Function of Neutrophils and Monocytes in Patients with Chronic Coronary Artery Disease: A Double‐Blind Randomized Placebo‐Controlled Cross‐Over Study |
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