Kinetics of the mechanically induced ibuprofen-nicotinamide co-crystal formation by in situ X-ray diffraction
Mechanochemistry is drawing attention from the pharmaceutical industry given its potential for sustainable material synthesis and manufacture. Scaling mechanochemical processes to industrial level remains a challenge due to an incomplete understanding of their underlying mechanisms. We here show how...
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| Veröffentlicht in: | Physical chemistry chemical physics : PCCP 2024-08, Vol.26 (33), p.22041-22048 |
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| container_issue | 33 |
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| container_title | Physical chemistry chemical physics : PCCP |
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| creator | Casali, Lucia Carta, Maria Michalchuk, Adam A L Delogu, Francesco Emmerling, Franziska |
| description | Mechanochemistry is drawing attention from the pharmaceutical industry given its potential for sustainable material synthesis and manufacture. Scaling mechanochemical processes to industrial level remains a challenge due to an incomplete understanding of their underlying mechanisms. We here show how time-resolved
powder X-ray diffraction data, coupled with analytical kinetic modelling, provides a powerful approach to gain mechanistic insight into mechanochemical reactions. By using the ibuprofen-nicotinamide co-crystal mechanosynthesis as a benchmark system, we investigate the behaviour of the solids involved and identify the factors that promote the reaction. As mechanochemical mechanisms become increasingly clear, it promises to become a breakthrough in the industrial preparation of advanced pharmaceuticals. |
| doi_str_mv | 10.1039/d4cp01457j |
| format | Article |
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| ispartof | Physical chemistry chemical physics : PCCP, 2024-08, Vol.26 (33), p.22041-22048 |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Ibuprofen Nicotinamide Pharmaceuticals X ray powder diffraction X-ray diffraction |
| title | Kinetics of the mechanically induced ibuprofen-nicotinamide co-crystal formation by in situ X-ray diffraction |
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