RBM25 depletion suppresses the growth of colon cancer cells through regulating alternative splicing of MNK2

Increasing evidence suggests that deregulated RNA splicing factors play critical roles in tumorigenesis; however, their specific involvement in colon cancer remains largely unknown. Here we report that the splicing factor RBM25 is overexpressed in colon cancer, and this increased expression correlat...

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Veröffentlicht in:	Science China. Life sciences 2024-10, Vol.67 (10), p.2186-2197
Hauptverfasser:	Zhi, Lili, Chen, Chaoqun, Zhang, Ge, Huang, Tian, He, Wenxia, Zhang, Jinrui, Chen, Dan, Liu, Jiayi, Zhao, Jinyao, Qi, Yangfan, Wang, Guiying, Zhang, Wenjing, Wang, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Biomedical and Life Sciences Cell Line, Tumor Cell Proliferation - genetics Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Exons - genetics Gene Expression Regulation, Neoplastic Genomic analysis Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Life Sciences Mice Mice, Nude Prognosis Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Research Paper RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Splicing factors Therapeutic targets Transcriptomes Tumor suppression Tumorigenesis
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