The novel thromboxane prostanoid receptor mediates CTGF production to drive human nasal fibroblast self‐migration through NF‐κB and PKCδ‐CREB signaling pathways

Chronic rhinosinusitis without nasal polyp (CRSsNP) is characterized by tissue repair/remodeling and the subepithelial stroma region in whose nasal mucosa has been reported by us to have thromboxane A2 (TXA2) prostanoid (TP) receptor and overexpress connective tissue growth factor (CTGF). Therefore,...

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Veröffentlicht in:	Journal of cellular physiology 2024-09, Vol.239 (9), p.e31390-n/a
Hauptverfasser:	Chang, Shih‐Lun, Tsai, Yih‐Jeng, Shieh, Jiunn‐Min, Wu, Wen‐Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Acetic acid Adult Assaying CCN2 Cell migration Cell Movement - drug effects Cell proliferation Cells, Cultured Cellular manufacture cellular signaling chronic rhinosinusitis Connective tissue growth factor Connective Tissue Growth Factor - genetics Connective Tissue Growth Factor - metabolism Connective tissues CRSsNP Cyclic AMP Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Female Fibers Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Filopodia Gene expression Growth factors Humans Lamellipodia Male Mucosa Nasal Mucosa - metabolism NF-kappa B - genetics NF-kappa B - metabolism Phosphorylation Polyps Protein kinase C Protein Kinase C-delta - genetics Protein Kinase C-delta - metabolism Proteins Receptor mechanisms Receptors Receptors, Thromboxane - genetics Receptors, Thromboxane - metabolism Rhinitis - genetics Rhinitis - metabolism Rhinitis - pathology Rhinosinusitis RNA-mediated interference Signal transduction Signal Transduction - drug effects Sinusitis - genetics Sinusitis - metabolism Sinusitis - pathology siRNA Stroma Thromboxane A2 TXA2 Wound healing
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