Assessment of Endoscopy-Based Scoring Systems for Prognostication in Ulcerative Colitis: A Comparative Analysis
Background and Objective Endoscopy-based scoring systems, including Mayo Endoscopic Score (MES), Modified Mayo Endoscopic Score (MMES), and Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) Score, have been introduced to evaluate UC prognosis. This study aims to compare their pred...
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| Veröffentlicht in: | Digestive diseases and sciences 2024-10, Vol.69 (10), p.3901-3910 |
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| creator | Zhang, Pingxin Zhang, Chuhan Chen, Baili He, Yao Zeng, Zhirong Mao, Ren Qiu, Yun Chen, Minhu |
| description | Background and Objective
Endoscopy-based scoring systems, including Mayo Endoscopic Score (MES), Modified Mayo Endoscopic Score (MMES), and Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) Score, have been introduced to evaluate UC prognosis. This study aims to compare their predictive capacity for clinical outcomes in UC patients.
Methods
Consecutive UC patients from a tertiary hospital were included. The primary outcome was acute severe ulcerative colitis (ASUC), and secondary outcomes were UC-related admission, medication treatment escalation, disease extension and surgery. Predictive performance was assessed using receiver operating characteristic (ROC) curves.
Results
Among 300 patients, 15.3% developed ASUC. Robust correlations were observed among the three scoring systems and were with elevated serum inflammatory markers. The DUBLIN score exhibited superior predictive ability for UC-related admission (AUC 0.751; 95%CI 0.698–0.799) and medication treatment escalation (AUC 0.735; 95% CI 0.681–0.784). No statistical differences were found among three scoring systems for predicting ASUC, disease extension, and surgery. Employing respective cut-offs of 2, 11.25, and 3, higher MES (HR = 3.859, 95% CI 1.636–9.107, p = 0.002), MMES (HR = 3.352, 95% CI 1.879–5.980, p |
| doi_str_mv | 10.1007/s10620-024-08582-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3089513222</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3089513222</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-a45919369e0faf9d40317c7d1bbed043b2258f5d8dbc49da60f80ec653d3d5353</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhoMo7jj6BzxIwIuX1qqk0532NjusH7CgsO45pJP0kqW706Z6hPn3Zp1RwYOn-uCpt4p6GXuJ8BYB2neE0AioQNQVaKVFpR-xDapWVkI1-jHbADYlR2wu2DOiewDoWmyesgvZISjdthuWdkSBaArzytPAr2afyKXlWF1aCp7fuJTjfMdvjrSGifiQMv-a092caI3OrjHNPM78dnQhl-pH4Ps0xjXSe74r6bTYc3s32_FIkZ6zJ4MdKbw4xy27_XD1bf-puv7y8fN-d125cvta2Vp12MmmCzDYofM1SGxd67Hvg4da9kIoPSivfe_qztsGBg3BNUp66ZVUcsvenHSXnL4fAq1miuTCONo5pAMZCbpTKIUQBX39D3qfDrncWyhEjQUp5JaJE-VyIsphMEuOk81Hg2Ae7DAnO0yxw_yyw-gy9Oosfein4P-M_P5_AeQJoOXhzyH_3f0f2Z8hB5YG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3118122351</pqid></control><display><type>article</type><title>Assessment of Endoscopy-Based Scoring Systems for Prognostication in Ulcerative Colitis: A Comparative Analysis</title><source>SpringerNature Journals</source><creator>Zhang, Pingxin ; Zhang, Chuhan ; Chen, Baili ; He, Yao ; Zeng, Zhirong ; Mao, Ren ; Qiu, Yun ; Chen, Minhu</creator><creatorcontrib>Zhang, Pingxin ; Zhang, Chuhan ; Chen, Baili ; He, Yao ; Zeng, Zhirong ; Mao, Ren ; Qiu, Yun ; Chen, Minhu</creatorcontrib><description>Background and Objective
Endoscopy-based scoring systems, including Mayo Endoscopic Score (MES), Modified Mayo Endoscopic Score (MMES), and Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) Score, have been introduced to evaluate UC prognosis. This study aims to compare their predictive capacity for clinical outcomes in UC patients.
Methods
Consecutive UC patients from a tertiary hospital were included. The primary outcome was acute severe ulcerative colitis (ASUC), and secondary outcomes were UC-related admission, medication treatment escalation, disease extension and surgery. Predictive performance was assessed using receiver operating characteristic (ROC) curves.
Results
Among 300 patients, 15.3% developed ASUC. Robust correlations were observed among the three scoring systems and were with elevated serum inflammatory markers. The DUBLIN score exhibited superior predictive ability for UC-related admission (AUC 0.751; 95%CI 0.698–0.799) and medication treatment escalation (AUC 0.735; 95% CI 0.681–0.784). No statistical differences were found among three scoring systems for predicting ASUC, disease extension, and surgery. Employing respective cut-offs of 2, 11.25, and 3, higher MES (HR = 3.859, 95% CI 1.636–9.107, p = 0.002), MMES (HR = 3.352, 95% CI 1.879–5.980, p < 0.001), and DUBLIN score (HR = 5.619, 95% CI 2.378–13.277, p < 0.001) were associated with an increased risk of developing ASUC.
Conclusion
The DUBLIN score, assessing the overall inflammatory burden of the intestinal tract, outperforms the MMES in predicting admission and medication treatment escalation related to UC. Its integration into clinical practice has the potential to enhance risk stratification for patients with UC.</description><identifier>ISSN: 0163-2116</identifier><identifier>ISSN: 1573-2568</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-024-08582-8</identifier><identifier>PMID: 39105877</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Cohort analysis ; Endoscopy ; Gastroenterology ; Hepatology ; Inflammatory bowel disease ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Transplant Surgery</subject><ispartof>Digestive diseases and sciences, 2024-10, Vol.69 (10), p.3901-3910</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-a45919369e0faf9d40317c7d1bbed043b2258f5d8dbc49da60f80ec653d3d5353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-024-08582-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-024-08582-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39105877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Pingxin</creatorcontrib><creatorcontrib>Zhang, Chuhan</creatorcontrib><creatorcontrib>Chen, Baili</creatorcontrib><creatorcontrib>He, Yao</creatorcontrib><creatorcontrib>Zeng, Zhirong</creatorcontrib><creatorcontrib>Mao, Ren</creatorcontrib><creatorcontrib>Qiu, Yun</creatorcontrib><creatorcontrib>Chen, Minhu</creatorcontrib><title>Assessment of Endoscopy-Based Scoring Systems for Prognostication in Ulcerative Colitis: A Comparative Analysis</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background and Objective
Endoscopy-based scoring systems, including Mayo Endoscopic Score (MES), Modified Mayo Endoscopic Score (MMES), and Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) Score, have been introduced to evaluate UC prognosis. This study aims to compare their predictive capacity for clinical outcomes in UC patients.
Methods
Consecutive UC patients from a tertiary hospital were included. The primary outcome was acute severe ulcerative colitis (ASUC), and secondary outcomes were UC-related admission, medication treatment escalation, disease extension and surgery. Predictive performance was assessed using receiver operating characteristic (ROC) curves.
Results
Among 300 patients, 15.3% developed ASUC. Robust correlations were observed among the three scoring systems and were with elevated serum inflammatory markers. The DUBLIN score exhibited superior predictive ability for UC-related admission (AUC 0.751; 95%CI 0.698–0.799) and medication treatment escalation (AUC 0.735; 95% CI 0.681–0.784). No statistical differences were found among three scoring systems for predicting ASUC, disease extension, and surgery. Employing respective cut-offs of 2, 11.25, and 3, higher MES (HR = 3.859, 95% CI 1.636–9.107, p = 0.002), MMES (HR = 3.352, 95% CI 1.879–5.980, p < 0.001), and DUBLIN score (HR = 5.619, 95% CI 2.378–13.277, p < 0.001) were associated with an increased risk of developing ASUC.
Conclusion
The DUBLIN score, assessing the overall inflammatory burden of the intestinal tract, outperforms the MMES in predicting admission and medication treatment escalation related to UC. Its integration into clinical practice has the potential to enhance risk stratification for patients with UC.</description><subject>Biochemistry</subject><subject>Cohort analysis</subject><subject>Endoscopy</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Inflammatory bowel disease</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Transplant Surgery</subject><issn>0163-2116</issn><issn>1573-2568</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kU2LFDEQhoMo7jj6BzxIwIuX1qqk0532NjusH7CgsO45pJP0kqW706Z6hPn3Zp1RwYOn-uCpt4p6GXuJ8BYB2neE0AioQNQVaKVFpR-xDapWVkI1-jHbADYlR2wu2DOiewDoWmyesgvZISjdthuWdkSBaArzytPAr2afyKXlWF1aCp7fuJTjfMdvjrSGifiQMv-a092caI3OrjHNPM78dnQhl-pH4Ps0xjXSe74r6bTYc3s32_FIkZ6zJ4MdKbw4xy27_XD1bf-puv7y8fN-d125cvta2Vp12MmmCzDYofM1SGxd67Hvg4da9kIoPSivfe_qztsGBg3BNUp66ZVUcsvenHSXnL4fAq1miuTCONo5pAMZCbpTKIUQBX39D3qfDrncWyhEjQUp5JaJE-VyIsphMEuOk81Hg2Ae7DAnO0yxw_yyw-gy9Oosfein4P-M_P5_AeQJoOXhzyH_3f0f2Z8hB5YG</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Zhang, Pingxin</creator><creator>Zhang, Chuhan</creator><creator>Chen, Baili</creator><creator>He, Yao</creator><creator>Zeng, Zhirong</creator><creator>Mao, Ren</creator><creator>Qiu, Yun</creator><creator>Chen, Minhu</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20241001</creationdate><title>Assessment of Endoscopy-Based Scoring Systems for Prognostication in Ulcerative Colitis: A Comparative Analysis</title><author>Zhang, Pingxin ; Zhang, Chuhan ; Chen, Baili ; He, Yao ; Zeng, Zhirong ; Mao, Ren ; Qiu, Yun ; Chen, Minhu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-a45919369e0faf9d40317c7d1bbed043b2258f5d8dbc49da60f80ec653d3d5353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biochemistry</topic><topic>Cohort analysis</topic><topic>Endoscopy</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Inflammatory bowel disease</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Transplant Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Pingxin</creatorcontrib><creatorcontrib>Zhang, Chuhan</creatorcontrib><creatorcontrib>Chen, Baili</creatorcontrib><creatorcontrib>He, Yao</creatorcontrib><creatorcontrib>Zeng, Zhirong</creatorcontrib><creatorcontrib>Mao, Ren</creatorcontrib><creatorcontrib>Qiu, Yun</creatorcontrib><creatorcontrib>Chen, Minhu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Pingxin</au><au>Zhang, Chuhan</au><au>Chen, Baili</au><au>He, Yao</au><au>Zeng, Zhirong</au><au>Mao, Ren</au><au>Qiu, Yun</au><au>Chen, Minhu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of Endoscopy-Based Scoring Systems for Prognostication in Ulcerative Colitis: A Comparative Analysis</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>69</volume><issue>10</issue><spage>3901</spage><epage>3910</epage><pages>3901-3910</pages><issn>0163-2116</issn><issn>1573-2568</issn><eissn>1573-2568</eissn><abstract>Background and Objective
Endoscopy-based scoring systems, including Mayo Endoscopic Score (MES), Modified Mayo Endoscopic Score (MMES), and Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) Score, have been introduced to evaluate UC prognosis. This study aims to compare their predictive capacity for clinical outcomes in UC patients.
Methods
Consecutive UC patients from a tertiary hospital were included. The primary outcome was acute severe ulcerative colitis (ASUC), and secondary outcomes were UC-related admission, medication treatment escalation, disease extension and surgery. Predictive performance was assessed using receiver operating characteristic (ROC) curves.
Results
Among 300 patients, 15.3% developed ASUC. Robust correlations were observed among the three scoring systems and were with elevated serum inflammatory markers. The DUBLIN score exhibited superior predictive ability for UC-related admission (AUC 0.751; 95%CI 0.698–0.799) and medication treatment escalation (AUC 0.735; 95% CI 0.681–0.784). No statistical differences were found among three scoring systems for predicting ASUC, disease extension, and surgery. Employing respective cut-offs of 2, 11.25, and 3, higher MES (HR = 3.859, 95% CI 1.636–9.107, p = 0.002), MMES (HR = 3.352, 95% CI 1.879–5.980, p < 0.001), and DUBLIN score (HR = 5.619, 95% CI 2.378–13.277, p < 0.001) were associated with an increased risk of developing ASUC.
Conclusion
The DUBLIN score, assessing the overall inflammatory burden of the intestinal tract, outperforms the MMES in predicting admission and medication treatment escalation related to UC. Its integration into clinical practice has the potential to enhance risk stratification for patients with UC.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39105877</pmid><doi>10.1007/s10620-024-08582-8</doi><tpages>10</tpages></addata></record> |
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| subjects | Biochemistry Cohort analysis Endoscopy Gastroenterology Hepatology Inflammatory bowel disease Medicine Medicine & Public Health Oncology Original Article Transplant Surgery |
| title | Assessment of Endoscopy-Based Scoring Systems for Prognostication in Ulcerative Colitis: A Comparative Analysis |
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