Longitudinal epidemiology of multiple sclerosis over 60 years in Newcastle, Australia: 1961 to 2021
•2021 Newcastle MS prevalence was 173.1/100,000 (age-standardised = 178.7/100,00).•2011–21 Newcastle MS incidence rate from onset was 3.7 (standardised = 3.5).•Prevalence and incidence rate were higher among Australian vs overseas-born.•Mortality rate was 2.1/100,000, with standardised mortality rat...
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| Veröffentlicht in: | Multiple sclerosis and related disorders 2024-10, Vol.90, p.105786, Article 105786 |
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| creator | Simpson-Yap, Steve Maltby, Vicki E. Hall, Stacey Ward, Sophia Lea, Rodney Boggild, Mike Kalincik, Tomas Shaw, Cameron Taylor, Bruce van der Walt, Anneke Lechner-Scott, Jeannette |
| description | •2021 Newcastle MS prevalence was 173.1/100,000 (age-standardised = 178.7/100,00).•2011–21 Newcastle MS incidence rate from onset was 3.7 (standardised = 3.5).•Prevalence and incidence rate were higher among Australian vs overseas-born.•Mortality rate was 2.1/100,000, with standardised mortality ratio = 1.6.
Newcastle, Australia, has been serially studied for MS epidemiology since 1961, showing consistently increasing prevalence estimates and incidence rates, including to our 2011 study.
To assess the 2011–2021 epidemiology of MS in Newcastle and to compare with previous measures.
Demographic and clinical data were extracted from medical records of MS cases residing in Newcastle, as identified by public and private clinicians. Prevalence (2011 and 2021) and incidence rates (2011-2021, from onset and from diagnosis) and mortality rate (2011–2021) were estimated and age-standardised to the 2021 Australian population.
The 2021 prevalence was 173.1/100,000 (age-standardised = 178.7/100,000, F/M-sex-ratio = 3.3), a 42.2 % increase from 2011 (F/M-sex-ratio = 3.1), 175.0 % from 1996 (F/M-sex-ratio = 2.6), and 831.0 % from 1961 (F/M-sex-ratio = 1.2). The 2011–21 age-standardised onset incidence rate was 3.5/100,000 person-years (F/M-sex-ratio = 2.8), a 68.7 % increase from 1971 to 81 (F/M-sex-ratio = 1.1) and 44.5 % from 1986 to 96 (F/M-sex-ratio = 2.3). The age-standardised diagnosis incidence rate was 6.1/100,000 (F/M-sex-ratio = 2.2), statistically unchanged from that in 2001–2011 (6.8/100,000, F/M-sex-ratio = 3.2). The 2011–21 mortality rate was 2.1/100,000 person-years (2.2 age-standardised, F/M-sex-ratio = 1.4), with a standardised mortality ratio of 1.6.
The Newcastle region continues to be a high frequency zone for MS. The incidence rate from onset is significantly increased from previous estimates, but incidence rate from diagnosis is stable. Prevalence and incidence sex ratios have stabilised at roughly 3.0, similar to other Australian sites. |
| doi_str_mv | 10.1016/j.msard.2024.105786 |
| format | Article |
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Newcastle, Australia, has been serially studied for MS epidemiology since 1961, showing consistently increasing prevalence estimates and incidence rates, including to our 2011 study.
To assess the 2011–2021 epidemiology of MS in Newcastle and to compare with previous measures.
Demographic and clinical data were extracted from medical records of MS cases residing in Newcastle, as identified by public and private clinicians. Prevalence (2011 and 2021) and incidence rates (2011-2021, from onset and from diagnosis) and mortality rate (2011–2021) were estimated and age-standardised to the 2021 Australian population.
The 2021 prevalence was 173.1/100,000 (age-standardised = 178.7/100,000, F/M-sex-ratio = 3.3), a 42.2 % increase from 2011 (F/M-sex-ratio = 3.1), 175.0 % from 1996 (F/M-sex-ratio = 2.6), and 831.0 % from 1961 (F/M-sex-ratio = 1.2). The 2011–21 age-standardised onset incidence rate was 3.5/100,000 person-years (F/M-sex-ratio = 2.8), a 68.7 % increase from 1971 to 81 (F/M-sex-ratio = 1.1) and 44.5 % from 1986 to 96 (F/M-sex-ratio = 2.3). The age-standardised diagnosis incidence rate was 6.1/100,000 (F/M-sex-ratio = 2.2), statistically unchanged from that in 2001–2011 (6.8/100,000, F/M-sex-ratio = 3.2). The 2011–21 mortality rate was 2.1/100,000 person-years (2.2 age-standardised, F/M-sex-ratio = 1.4), with a standardised mortality ratio of 1.6.
The Newcastle region continues to be a high frequency zone for MS. The incidence rate from onset is significantly increased from previous estimates, but incidence rate from diagnosis is stable. Prevalence and incidence sex ratios have stabilised at roughly 3.0, similar to other Australian sites.</description><identifier>ISSN: 2211-0348</identifier><identifier>ISSN: 2211-0356</identifier><identifier>EISSN: 2211-0356</identifier><identifier>DOI: 10.1016/j.msard.2024.105786</identifier><identifier>PMID: 39098057</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Incidence ; Mortality ; Multiple sclerosis ; Newcastle ; Prevalence</subject><ispartof>Multiple sclerosis and related disorders, 2024-10, Vol.90, p.105786, Article 105786</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c239t-678448dcee51cb5aa566c95b8b9ac27313842b5b4486e9bdc7a38157b8a7b373</cites><orcidid>0000-0001-6521-3056</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39098057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simpson-Yap, Steve</creatorcontrib><creatorcontrib>Maltby, Vicki E.</creatorcontrib><creatorcontrib>Hall, Stacey</creatorcontrib><creatorcontrib>Ward, Sophia</creatorcontrib><creatorcontrib>Lea, Rodney</creatorcontrib><creatorcontrib>Boggild, Mike</creatorcontrib><creatorcontrib>Kalincik, Tomas</creatorcontrib><creatorcontrib>Shaw, Cameron</creatorcontrib><creatorcontrib>Taylor, Bruce</creatorcontrib><creatorcontrib>van der Walt, Anneke</creatorcontrib><creatorcontrib>Lechner-Scott, Jeannette</creatorcontrib><title>Longitudinal epidemiology of multiple sclerosis over 60 years in Newcastle, Australia: 1961 to 2021</title><title>Multiple sclerosis and related disorders</title><addtitle>Mult Scler Relat Disord</addtitle><description>•2021 Newcastle MS prevalence was 173.1/100,000 (age-standardised = 178.7/100,00).•2011–21 Newcastle MS incidence rate from onset was 3.7 (standardised = 3.5).•Prevalence and incidence rate were higher among Australian vs overseas-born.•Mortality rate was 2.1/100,000, with standardised mortality ratio = 1.6.
Newcastle, Australia, has been serially studied for MS epidemiology since 1961, showing consistently increasing prevalence estimates and incidence rates, including to our 2011 study.
To assess the 2011–2021 epidemiology of MS in Newcastle and to compare with previous measures.
Demographic and clinical data were extracted from medical records of MS cases residing in Newcastle, as identified by public and private clinicians. Prevalence (2011 and 2021) and incidence rates (2011-2021, from onset and from diagnosis) and mortality rate (2011–2021) were estimated and age-standardised to the 2021 Australian population.
The 2021 prevalence was 173.1/100,000 (age-standardised = 178.7/100,000, F/M-sex-ratio = 3.3), a 42.2 % increase from 2011 (F/M-sex-ratio = 3.1), 175.0 % from 1996 (F/M-sex-ratio = 2.6), and 831.0 % from 1961 (F/M-sex-ratio = 1.2). The 2011–21 age-standardised onset incidence rate was 3.5/100,000 person-years (F/M-sex-ratio = 2.8), a 68.7 % increase from 1971 to 81 (F/M-sex-ratio = 1.1) and 44.5 % from 1986 to 96 (F/M-sex-ratio = 2.3). The age-standardised diagnosis incidence rate was 6.1/100,000 (F/M-sex-ratio = 2.2), statistically unchanged from that in 2001–2011 (6.8/100,000, F/M-sex-ratio = 3.2). The 2011–21 mortality rate was 2.1/100,000 person-years (2.2 age-standardised, F/M-sex-ratio = 1.4), with a standardised mortality ratio of 1.6.
The Newcastle region continues to be a high frequency zone for MS. The incidence rate from onset is significantly increased from previous estimates, but incidence rate from diagnosis is stable. Prevalence and incidence sex ratios have stabilised at roughly 3.0, similar to other Australian sites.</description><subject>Incidence</subject><subject>Mortality</subject><subject>Multiple sclerosis</subject><subject>Newcastle</subject><subject>Prevalence</subject><issn>2211-0348</issn><issn>2211-0356</issn><issn>2211-0356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PAyEQhonRWKP9BSaGowdbYVlY1sRDY_xKGr30ToCdNjTsUmG3pv9eatWjXCCT52VmHoQuKZlSQsXtetomHZtpQYoyV3glxRE6KwpKJ4Rxcfz3LuUIjVNak3wEp6Wgp2jEalLLHDpDdh66leuHxnXaY9i4BloXfFjtcFjidvC923jAyXqIIbmEwxYiFgTvQMeEXYff4NPq1Hu4wbMh9VF7p-8wrQXFfcB5PnqBTpbaJxj_3Odo8fS4eHiZzN-fXx9m84ktWN1PRCXLUjYWgFNruNZcCFtzI02tbVExymRZGG4yJKA2ja00k5RXRurKsIqdo-vDt5sYPgZIvWpdsuC97iAMSTEiJeec0D3KDqjNS6UIS7WJrtVxpyhRe79qrb79qr1fdfCbU1c_DQbTQvOX-bWZgfsDAHnLrYOoknXQWWhcBNurJrh_G3wBgQ2LFA</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Simpson-Yap, Steve</creator><creator>Maltby, Vicki E.</creator><creator>Hall, Stacey</creator><creator>Ward, Sophia</creator><creator>Lea, Rodney</creator><creator>Boggild, Mike</creator><creator>Kalincik, Tomas</creator><creator>Shaw, Cameron</creator><creator>Taylor, Bruce</creator><creator>van der Walt, Anneke</creator><creator>Lechner-Scott, Jeannette</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6521-3056</orcidid></search><sort><creationdate>20241001</creationdate><title>Longitudinal epidemiology of multiple sclerosis over 60 years in Newcastle, Australia: 1961 to 2021</title><author>Simpson-Yap, Steve ; Maltby, Vicki E. ; Hall, Stacey ; Ward, Sophia ; Lea, Rodney ; Boggild, Mike ; Kalincik, Tomas ; Shaw, Cameron ; Taylor, Bruce ; van der Walt, Anneke ; Lechner-Scott, Jeannette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c239t-678448dcee51cb5aa566c95b8b9ac27313842b5b4486e9bdc7a38157b8a7b373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Incidence</topic><topic>Mortality</topic><topic>Multiple sclerosis</topic><topic>Newcastle</topic><topic>Prevalence</topic><toplevel>online_resources</toplevel><creatorcontrib>Simpson-Yap, Steve</creatorcontrib><creatorcontrib>Maltby, Vicki E.</creatorcontrib><creatorcontrib>Hall, Stacey</creatorcontrib><creatorcontrib>Ward, Sophia</creatorcontrib><creatorcontrib>Lea, Rodney</creatorcontrib><creatorcontrib>Boggild, Mike</creatorcontrib><creatorcontrib>Kalincik, Tomas</creatorcontrib><creatorcontrib>Shaw, Cameron</creatorcontrib><creatorcontrib>Taylor, Bruce</creatorcontrib><creatorcontrib>van der Walt, Anneke</creatorcontrib><creatorcontrib>Lechner-Scott, Jeannette</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Multiple sclerosis and related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simpson-Yap, Steve</au><au>Maltby, Vicki E.</au><au>Hall, Stacey</au><au>Ward, Sophia</au><au>Lea, Rodney</au><au>Boggild, Mike</au><au>Kalincik, Tomas</au><au>Shaw, Cameron</au><au>Taylor, Bruce</au><au>van der Walt, Anneke</au><au>Lechner-Scott, Jeannette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal epidemiology of multiple sclerosis over 60 years in Newcastle, Australia: 1961 to 2021</atitle><jtitle>Multiple sclerosis and related disorders</jtitle><addtitle>Mult Scler Relat Disord</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>90</volume><spage>105786</spage><pages>105786-</pages><artnum>105786</artnum><issn>2211-0348</issn><issn>2211-0356</issn><eissn>2211-0356</eissn><abstract>•2021 Newcastle MS prevalence was 173.1/100,000 (age-standardised = 178.7/100,00).•2011–21 Newcastle MS incidence rate from onset was 3.7 (standardised = 3.5).•Prevalence and incidence rate were higher among Australian vs overseas-born.•Mortality rate was 2.1/100,000, with standardised mortality ratio = 1.6.
Newcastle, Australia, has been serially studied for MS epidemiology since 1961, showing consistently increasing prevalence estimates and incidence rates, including to our 2011 study.
To assess the 2011–2021 epidemiology of MS in Newcastle and to compare with previous measures.
Demographic and clinical data were extracted from medical records of MS cases residing in Newcastle, as identified by public and private clinicians. Prevalence (2011 and 2021) and incidence rates (2011-2021, from onset and from diagnosis) and mortality rate (2011–2021) were estimated and age-standardised to the 2021 Australian population.
The 2021 prevalence was 173.1/100,000 (age-standardised = 178.7/100,000, F/M-sex-ratio = 3.3), a 42.2 % increase from 2011 (F/M-sex-ratio = 3.1), 175.0 % from 1996 (F/M-sex-ratio = 2.6), and 831.0 % from 1961 (F/M-sex-ratio = 1.2). The 2011–21 age-standardised onset incidence rate was 3.5/100,000 person-years (F/M-sex-ratio = 2.8), a 68.7 % increase from 1971 to 81 (F/M-sex-ratio = 1.1) and 44.5 % from 1986 to 96 (F/M-sex-ratio = 2.3). The age-standardised diagnosis incidence rate was 6.1/100,000 (F/M-sex-ratio = 2.2), statistically unchanged from that in 2001–2011 (6.8/100,000, F/M-sex-ratio = 3.2). The 2011–21 mortality rate was 2.1/100,000 person-years (2.2 age-standardised, F/M-sex-ratio = 1.4), with a standardised mortality ratio of 1.6.
The Newcastle region continues to be a high frequency zone for MS. The incidence rate from onset is significantly increased from previous estimates, but incidence rate from diagnosis is stable. Prevalence and incidence sex ratios have stabilised at roughly 3.0, similar to other Australian sites.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39098057</pmid><doi>10.1016/j.msard.2024.105786</doi><orcidid>https://orcid.org/0000-0001-6521-3056</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Incidence Mortality Multiple sclerosis Newcastle Prevalence |
| title | Longitudinal epidemiology of multiple sclerosis over 60 years in Newcastle, Australia: 1961 to 2021 |
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