Proximity labeling reveals dynamic changes in the SQSTM1 protein network

Sequestosome1 (SQSTM1) is an autophagy receptor that mediates the degradation of intracellular cargo, including protein aggregates, through multiple protein interactions. These interactions form the SQSTM1 protein network, and these interactions are mediated by SQSTM1 functional interaction domains,...

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Veröffentlicht in:	The Journal of biological chemistry 2024-09, Vol.300 (9), p.107621, Article 107621
Hauptverfasser:	Rondón-Ortiz, Alejandro N., Zhang, Lushuang, Ash, Peter E.A., Basu, Avik, Puri, Sambhavi, van der Spek, Sophie J.F., Wang, Zihan, Dorrian, Luke, Emili, Andrew, Wolozin, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism autophagy HEK293 Cells Humans MAPT p62 protein aggregation Protein Binding Protein Interaction Maps proximity labeling Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sequestosome-1 Protein - chemistry Sequestosome-1 Protein - genetics Sequestosome-1 Protein - metabolism SQSTM1 tau tau Proteins - chemistry tau Proteins - genetics tau Proteins - metabolism TurboID
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