Axonopathy Underlying Amyotrophic Lateral Sclerosis: Unraveling Complex Pathways and Therapeutic Insights

Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder characterized by progressive axonopathy, jointly leading to the dying back of the motor neuron, disrupting both nerve signaling and motor control. In this review, we highlight the roles of axonopathy in ALS progression, driv...

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Veröffentlicht in:	Neuroscience bulletin 2024-11, Vol.40 (11), p.1789-1810
Hauptverfasser:	Luan, Tongshu, Li, Qing, Huang, Zhi, Feng, Yu, Xu, Duo, Zhou, Yujie, Hu, Yiqing, Wang, Tong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - therapy Anatomy Anesthesiology Animals Axons - metabolism Axons - pathology Biomedical and Life Sciences Biomedicine Human Physiology Humans Mitochondria - metabolism Motor Neurons - metabolism Motor Neurons - pathology Neurology Neurosciences Pain Medicine Review
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