Vascular refilling in hemodialysis using feedback-controlled ultrafiltration profile
Background: The rate and the duration of ultrafiltration (UF) are considered the most important factors to affect vascular refilling. The aim of the study was to investigate whether a UF profile could improve the vascular refilling. Methods: Dialysis was delivered by a machine providing feedback con...
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| Veröffentlicht in: | International journal of artificial organs 2024-10, Vol.47 (10), p.723-728 |
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| creator | Broszeit, Stefanie Kron, Joachim Leimbach, Til Volkenandt, John Kron, Susanne |
| description | Background:
The rate and the duration of ultrafiltration (UF) are considered the most important factors to affect vascular refilling. The aim of the study was to investigate whether a UF profile could improve the vascular refilling.
Methods:
Dialysis was delivered by a machine providing feedback control of ultrafiltration rates. Absolute blood volume (BV) was measured by dialysate bolus method. Vascular refilling volume (Vref) was calculated as UF volume – Δ absolute BV.
Results:
In 40 patients, refilling fraction (Vref/UF volume) was 30.5% in the first hour. Thereafter, refilling fraction steeply increased and reached maximum values in the third and fourth hour at about 95%. The cumulative refilling fraction was 68.5 ± 9.4% at the end. In 14 patients, refilling data from the feedback-controlled UF profile were compared to dialysis sessions with constant UF rates. In 12 of 14 patients, refilling fraction was significantly (p = 0.013) higher in sessions with UF profile (71.6% vs 64.4%).
There was a significant negative correlation (r = -0.606; p = 0.002) between the blood volume to extracellular volume ratio and the refilling fraction. The sum of this ratio and the refilling fraction was 1.01 ± 0.06.
Conclusions:
Despite significant differences, a feedback-controlled UF profile has no advantage over the previous refilling studies with regard to the refilling fraction because vascular refilling seems to depend mainly on the ratio of BV to ECV. This would explain the different results in studies using BV guided UF feedback programs. |
| doi_str_mv | 10.1177/03913988241264709 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3087699208</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_03913988241264709</sage_id><sourcerecordid>3087699208</sourcerecordid><originalsourceid>FETCH-LOGICAL-c250t-24277134a82646dbf02a037243f5d8f87f8485f51c91f175e7c1ead50bfd64d43</originalsourceid><addsrcrecordid>eNp1kDtPwzAUhS0EoqXwA1hQJBaWFL8S2yNCvKRKLIU1cvwoLk5S7GTov8dRC0ggFlu-_s65RweAcwTnCDF2DYlARHCOKcIlZVAcgClimOYlpPAQTMf_fAQm4CTGNYSopLQ4BhMioGBMkClYvsqoBi9DFox13rt2lbk2ezNNp5302-hiNsRxao3RtVTvueraPnTeG50Nvg8yydLZu67NNqFLL3MKjqz00Zzt7xl4ub9b3j7mi-eHp9ubRa5wAfscU8wYIlTylL7UtYVYQpLyE1tobjmznPLCFkgJZBErDFPISF3A2uqSakpm4Grnm_Z-DCb2VeOiMt7L1nRDrAjkrBQCQ57Qy1_ouhtCm9JVBGFOSgzpSKEdpUIXY2qk2gTXyLCtEKzGyqs_lSfNxd55qBujvxVfHSdgvgOiXJmftf87fgLKkojG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3128362048</pqid></control><display><type>article</type><title>Vascular refilling in hemodialysis using feedback-controlled ultrafiltration profile</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><creator>Broszeit, Stefanie ; Kron, Joachim ; Leimbach, Til ; Volkenandt, John ; Kron, Susanne</creator><creatorcontrib>Broszeit, Stefanie ; Kron, Joachim ; Leimbach, Til ; Volkenandt, John ; Kron, Susanne</creatorcontrib><description>Background:
The rate and the duration of ultrafiltration (UF) are considered the most important factors to affect vascular refilling. The aim of the study was to investigate whether a UF profile could improve the vascular refilling.
Methods:
Dialysis was delivered by a machine providing feedback control of ultrafiltration rates. Absolute blood volume (BV) was measured by dialysate bolus method. Vascular refilling volume (Vref) was calculated as UF volume – Δ absolute BV.
Results:
In 40 patients, refilling fraction (Vref/UF volume) was 30.5% in the first hour. Thereafter, refilling fraction steeply increased and reached maximum values in the third and fourth hour at about 95%. The cumulative refilling fraction was 68.5 ± 9.4% at the end. In 14 patients, refilling data from the feedback-controlled UF profile were compared to dialysis sessions with constant UF rates. In 12 of 14 patients, refilling fraction was significantly (p = 0.013) higher in sessions with UF profile (71.6% vs 64.4%).
There was a significant negative correlation (r = -0.606; p = 0.002) between the blood volume to extracellular volume ratio and the refilling fraction. The sum of this ratio and the refilling fraction was 1.01 ± 0.06.
Conclusions:
Despite significant differences, a feedback-controlled UF profile has no advantage over the previous refilling studies with regard to the refilling fraction because vascular refilling seems to depend mainly on the ratio of BV to ECV. This would explain the different results in studies using BV guided UF feedback programs.</description><identifier>ISSN: 0391-3988</identifier><identifier>ISSN: 1724-6040</identifier><identifier>EISSN: 1724-6040</identifier><identifier>DOI: 10.1177/03913988241264709</identifier><identifier>PMID: 39097793</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Blood Volume ; Control systems ; Dialysis ; Feedback ; Feedback control ; Female ; Hemodiafiltration - methods ; Hemodialysis ; Humans ; Male ; Middle Aged ; Refilling ; Renal Dialysis - methods ; Ultrafiltration ; Ultrafiltration - methods</subject><ispartof>International journal of artificial organs, 2024-10, Vol.47 (10), p.723-728</ispartof><rights>The Author(s) 2024</rights><rights>Copyright Wichtig Editore s.r.l. Oct 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c250t-24277134a82646dbf02a037243f5d8f87f8485f51c91f175e7c1ead50bfd64d43</cites><orcidid>0000-0001-6556-979X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/03913988241264709$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/03913988241264709$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39097793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Broszeit, Stefanie</creatorcontrib><creatorcontrib>Kron, Joachim</creatorcontrib><creatorcontrib>Leimbach, Til</creatorcontrib><creatorcontrib>Volkenandt, John</creatorcontrib><creatorcontrib>Kron, Susanne</creatorcontrib><title>Vascular refilling in hemodialysis using feedback-controlled ultrafiltration profile</title><title>International journal of artificial organs</title><addtitle>Int J Artif Organs</addtitle><description>Background:
The rate and the duration of ultrafiltration (UF) are considered the most important factors to affect vascular refilling. The aim of the study was to investigate whether a UF profile could improve the vascular refilling.
Methods:
Dialysis was delivered by a machine providing feedback control of ultrafiltration rates. Absolute blood volume (BV) was measured by dialysate bolus method. Vascular refilling volume (Vref) was calculated as UF volume – Δ absolute BV.
Results:
In 40 patients, refilling fraction (Vref/UF volume) was 30.5% in the first hour. Thereafter, refilling fraction steeply increased and reached maximum values in the third and fourth hour at about 95%. The cumulative refilling fraction was 68.5 ± 9.4% at the end. In 14 patients, refilling data from the feedback-controlled UF profile were compared to dialysis sessions with constant UF rates. In 12 of 14 patients, refilling fraction was significantly (p = 0.013) higher in sessions with UF profile (71.6% vs 64.4%).
There was a significant negative correlation (r = -0.606; p = 0.002) between the blood volume to extracellular volume ratio and the refilling fraction. The sum of this ratio and the refilling fraction was 1.01 ± 0.06.
Conclusions:
Despite significant differences, a feedback-controlled UF profile has no advantage over the previous refilling studies with regard to the refilling fraction because vascular refilling seems to depend mainly on the ratio of BV to ECV. This would explain the different results in studies using BV guided UF feedback programs.</description><subject>Aged</subject><subject>Blood Volume</subject><subject>Control systems</subject><subject>Dialysis</subject><subject>Feedback</subject><subject>Feedback control</subject><subject>Female</subject><subject>Hemodiafiltration - methods</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Refilling</subject><subject>Renal Dialysis - methods</subject><subject>Ultrafiltration</subject><subject>Ultrafiltration - methods</subject><issn>0391-3988</issn><issn>1724-6040</issn><issn>1724-6040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAUhS0EoqXwA1hQJBaWFL8S2yNCvKRKLIU1cvwoLk5S7GTov8dRC0ggFlu-_s65RweAcwTnCDF2DYlARHCOKcIlZVAcgClimOYlpPAQTMf_fAQm4CTGNYSopLQ4BhMioGBMkClYvsqoBi9DFox13rt2lbk2ezNNp5302-hiNsRxao3RtVTvueraPnTeG50Nvg8yydLZu67NNqFLL3MKjqz00Zzt7xl4ub9b3j7mi-eHp9ubRa5wAfscU8wYIlTylL7UtYVYQpLyE1tobjmznPLCFkgJZBErDFPISF3A2uqSakpm4Grnm_Z-DCb2VeOiMt7L1nRDrAjkrBQCQ57Qy1_ouhtCm9JVBGFOSgzpSKEdpUIXY2qk2gTXyLCtEKzGyqs_lSfNxd55qBujvxVfHSdgvgOiXJmftf87fgLKkojG</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Broszeit, Stefanie</creator><creator>Kron, Joachim</creator><creator>Leimbach, Til</creator><creator>Volkenandt, John</creator><creator>Kron, Susanne</creator><general>SAGE Publications</general><general>Wichtig Editore s.r.l</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6556-979X</orcidid></search><sort><creationdate>202410</creationdate><title>Vascular refilling in hemodialysis using feedback-controlled ultrafiltration profile</title><author>Broszeit, Stefanie ; Kron, Joachim ; Leimbach, Til ; Volkenandt, John ; Kron, Susanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-24277134a82646dbf02a037243f5d8f87f8485f51c91f175e7c1ead50bfd64d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Blood Volume</topic><topic>Control systems</topic><topic>Dialysis</topic><topic>Feedback</topic><topic>Feedback control</topic><topic>Female</topic><topic>Hemodiafiltration - methods</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Refilling</topic><topic>Renal Dialysis - methods</topic><topic>Ultrafiltration</topic><topic>Ultrafiltration - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Broszeit, Stefanie</creatorcontrib><creatorcontrib>Kron, Joachim</creatorcontrib><creatorcontrib>Leimbach, Til</creatorcontrib><creatorcontrib>Volkenandt, John</creatorcontrib><creatorcontrib>Kron, Susanne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Broszeit, Stefanie</au><au>Kron, Joachim</au><au>Leimbach, Til</au><au>Volkenandt, John</au><au>Kron, Susanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular refilling in hemodialysis using feedback-controlled ultrafiltration profile</atitle><jtitle>International journal of artificial organs</jtitle><addtitle>Int J Artif Organs</addtitle><date>2024-10</date><risdate>2024</risdate><volume>47</volume><issue>10</issue><spage>723</spage><epage>728</epage><pages>723-728</pages><issn>0391-3988</issn><issn>1724-6040</issn><eissn>1724-6040</eissn><abstract>Background:
The rate and the duration of ultrafiltration (UF) are considered the most important factors to affect vascular refilling. The aim of the study was to investigate whether a UF profile could improve the vascular refilling.
Methods:
Dialysis was delivered by a machine providing feedback control of ultrafiltration rates. Absolute blood volume (BV) was measured by dialysate bolus method. Vascular refilling volume (Vref) was calculated as UF volume – Δ absolute BV.
Results:
In 40 patients, refilling fraction (Vref/UF volume) was 30.5% in the first hour. Thereafter, refilling fraction steeply increased and reached maximum values in the third and fourth hour at about 95%. The cumulative refilling fraction was 68.5 ± 9.4% at the end. In 14 patients, refilling data from the feedback-controlled UF profile were compared to dialysis sessions with constant UF rates. In 12 of 14 patients, refilling fraction was significantly (p = 0.013) higher in sessions with UF profile (71.6% vs 64.4%).
There was a significant negative correlation (r = -0.606; p = 0.002) between the blood volume to extracellular volume ratio and the refilling fraction. The sum of this ratio and the refilling fraction was 1.01 ± 0.06.
Conclusions:
Despite significant differences, a feedback-controlled UF profile has no advantage over the previous refilling studies with regard to the refilling fraction because vascular refilling seems to depend mainly on the ratio of BV to ECV. This would explain the different results in studies using BV guided UF feedback programs.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>39097793</pmid><doi>10.1177/03913988241264709</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6556-979X</orcidid></addata></record> |
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| ispartof | International journal of artificial organs, 2024-10, Vol.47 (10), p.723-728 |
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| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Aged Blood Volume Control systems Dialysis Feedback Feedback control Female Hemodiafiltration - methods Hemodialysis Humans Male Middle Aged Refilling Renal Dialysis - methods Ultrafiltration Ultrafiltration - methods |
| title | Vascular refilling in hemodialysis using feedback-controlled ultrafiltration profile |
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