Interleukin-35 alleviates neuropathic pain and induces an anti-inflammatory shift in spinal microglia in nerve-injured male mice

•IL-35 reduces mechanical pain more prominently in male than female mice with CCI.•CCI induces inflammatory microglial markers in the spinal cord dorsal horn.•IL-35 dampens expression of inflammatory microglial markers in male mice.•IL-35 promotes expression of anti-inflammatory microglial markers i...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2024-11, Vol.122, p.287-300
Hauptverfasser:	Fiore, Nathan T., Hayes, Jessica P., Williams, Sarah I., Moalem-Taylor, Gila
Format:	Artikel
Sprache:	eng
Schlagworte:	Interleukin-35 Microglia Neuroimmune Neuropathic pain Peripheral nerve injury Sex differences
Online-Zugang:	Volltext
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