Crosstalk between the DNA damage response and cellular senescence drives aging and age-related diseases

Cellular senescence is a crucial process of irreversible cell-cycle arrest, in which cells remain alive, but permanently unable to proliferate in response to distinct types of stressors. Accumulating evidence suggests that DNA damage builds over time and triggers DNA damage response signaling, leadi...

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Veröffentlicht in:	Seminars in immunopathology 2024-08, Vol.46 (3-4), p.10, Article 10
Hauptverfasser:	Ahmad, Ajmal, Braden, Anneliesse, Khan, Sazzad, Xiao, Jianfeng, Khan, Mohammad Moshahid
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - metabolism Animals Biomedical and Life Sciences Biomedicine Cellular Senescence Disease Susceptibility DNA Damage DNA Repair Humans Immunology Internal Medicine Neuroprotection Pathology Phenotypes Review Senescence Signal Transduction
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