The dimer effect: A refinement approach towards skin sensitization assessment in‐chemico using Amino acid Derivative Reactivity Assay

Skin sensitization is a key endpoint for safety assessment, especially for cosmetics and personal care products. The adverse outcome pathway for skin sensitization and the chemical and biological events driving the induction of human skin sensitization are now well understood. Several non‐animal tes...

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Veröffentlicht in:	Journal of applied toxicology 2024-11, Vol.44 (11), p.1804-1815
Hauptverfasser:	Paul Choudhury, Ratnadeep, Singh, Akanksha, Mathai, Eldho, Sudhakar, DGS, Tourneix, Fleur, Alépée, Nathalie, Gautier, Francoise
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine ADRA Allergens - chemistry Allergens - toxicity Amino acids Amino Acids - chemistry Animal Testing Alternatives - methods Assaying Biological Assay - methods Chemicals Consumer products Cosmetics Cosmetics - chemistry Cosmetics - toxicity Cysteine Depletion Dermatitis, Allergic Contact - etiology Dimerization Dimers DPRA Humans NAC NAC dimer OECD TG 442C Peptides Peptides - chemistry Peptides - toxicity Reactivity Skin Skin - drug effects Skin - metabolism skin sensitization Skin tests
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