MI2AMI-CS: A meta-analysis comparing Impella and IABP outcomes in Acute Myocardial Infarction-related Cardiogenic Shock
Cardiogenic Shock (CS) complicating acute myocardial infarction (AMI) poses a significant mortality risk, suggesting the opportunity to implement effective mechanical circulatory support strategies. The comparative efficacy of Intra-Aortic Balloon Pump (IABP) and Impella in managing CS-AMI remains a...
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| Veröffentlicht in: | International journal of cardiology 2024-11, Vol.414, p.132411, Article 132411 |
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| container_title | International journal of cardiology |
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| creator | De Ferrari, Tommaso Pistelli, Lorenzo Franzino, Marco Molinero, Agustin Ezequiel De Santis, Giulia Azzurra Di Carlo, Alessandro Vetta, Giampaolo Parlavecchio, Antonio Fimiani, Luigi Picci, Andrea Certo, Giuseppe Parisi, Francesca Venuti, Giuseppe |
| description | Cardiogenic Shock (CS) complicating acute myocardial infarction (AMI) poses a significant mortality risk, suggesting the opportunity to implement effective mechanical circulatory support strategies. The comparative efficacy of Intra-Aortic Balloon Pump (IABP) and Impella in managing CS-AMI remains a subject of investigation.
This meta-analysis aims to evaluate the comparative effectiveness of Impella and IABP in managing CS-AMI, exploring mortality and adverse events.
A systematic search of major databases from inception to November 2023 identified eight studies, comprising 10,628 patients, comparing Impella and IABP in CS-AMI. Retrospective studies (preferably Propensity-matched) and Randomized Clinical Trials (RCTs) were included.
Impella use exhibited significantly higher mortality (57% vs. 46%; OR: 1.44, 95% CI: 1.29–1.60; p |
| doi_str_mv | 10.1016/j.ijcard.2024.132411 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3087562640</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167527324010337</els_id><sourcerecordid>3087562640</sourcerecordid><originalsourceid>FETCH-LOGICAL-c287t-e0378cbb6ab0924f1a2e879a9e3ddb52e5f57d8b3bc3720f7d68cf0893a634943</originalsourceid><addsrcrecordid>eNp9kMuO1DAQRS0EYpqBP0DISzZp_Epss0DKtHhEmhZIA2vLsSuDmyRu7ATUf0-iDCxZ1aLOrcdB6CUle0po9ea0Dydnk98zwsSeciYofYR2VElRUFmKx2i3YLIomeRX6FnOJ0KI0Fo9RVdcEy0qXu7Q72PD6mNTHO7e4hoPMNnCjra_5JCxi8PZpjDe42Y4Q99bbEePm_rmC47ztHQh4zDi2s0T4OMlrtcE2-Nm7GxyU4hjkaC3E3h8WFvxHsbg8N336H48R08622d48VCv0bcP778ePhW3nz82h_q2cEzJqQDCpXJtW9mWaCY6ahkoqa0G7n1bMii7UnrV8tZxyUgnfaVcR5TmtuJCC36NXm9zzyn-nCFPZgjZrc-MEOdsOFGyrFglyIKKDXUp5pygM-cUBpsuhhKzKjcnsyk3q3KzKV9irx42zO0A_l_or-MFeLcBsPz5K0Ay2QUYHfiQwE3Gx_D_DX8AK-iTXQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3087562640</pqid></control><display><type>article</type><title>MI2AMI-CS: A meta-analysis comparing Impella and IABP outcomes in Acute Myocardial Infarction-related Cardiogenic Shock</title><source>Access via ScienceDirect (Elsevier)</source><creator>De Ferrari, Tommaso ; Pistelli, Lorenzo ; Franzino, Marco ; Molinero, Agustin Ezequiel ; De Santis, Giulia Azzurra ; Di Carlo, Alessandro ; Vetta, Giampaolo ; Parlavecchio, Antonio ; Fimiani, Luigi ; Picci, Andrea ; Certo, Giuseppe ; Parisi, Francesca ; Venuti, Giuseppe</creator><creatorcontrib>De Ferrari, Tommaso ; Pistelli, Lorenzo ; Franzino, Marco ; Molinero, Agustin Ezequiel ; De Santis, Giulia Azzurra ; Di Carlo, Alessandro ; Vetta, Giampaolo ; Parlavecchio, Antonio ; Fimiani, Luigi ; Picci, Andrea ; Certo, Giuseppe ; Parisi, Francesca ; Venuti, Giuseppe</creatorcontrib><description>Cardiogenic Shock (CS) complicating acute myocardial infarction (AMI) poses a significant mortality risk, suggesting the opportunity to implement effective mechanical circulatory support strategies. The comparative efficacy of Intra-Aortic Balloon Pump (IABP) and Impella in managing CS-AMI remains a subject of investigation.
This meta-analysis aims to evaluate the comparative effectiveness of Impella and IABP in managing CS-AMI, exploring mortality and adverse events.
A systematic search of major databases from inception to November 2023 identified eight studies, comprising 10,628 patients, comparing Impella and IABP in CS-AMI. Retrospective studies (preferably Propensity-matched) and Randomized Clinical Trials (RCTs) were included.
Impella use exhibited significantly higher mortality (57% vs. 46%; OR: 1.44, 95% CI: 1.29–1.60; p < 0.001) and major bleeding (30% vs 15%; OR: 2.93, 95% CI: 1.67–5.13; p < 0.001).
In unselected CS-AMI patients, Impella usage is associated with significantly higher mortality and major bleeding.
[Display omitted]
•In unselected patients with AMI complicated by CS, use of Impella is burdened by higher mortality compared to IABP.•Higher mortality with Impella is likely attributable to increased rate of major bleeding and renal complications.•Since not all patients benefit from Impella, its usage should be tailored to the patient clinical presentation.</description><identifier>ISSN: 0167-5273</identifier><identifier>ISSN: 1874-1754</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2024.132411</identifier><identifier>PMID: 39094635</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acute myocardial infarction ; Adverse events ; Cardiogenic shock ; Impella ; Intra-aortic balloon pump ; Major bleeding ; Mortality ; Percutaneous mechanical circulatory support</subject><ispartof>International journal of cardiology, 2024-11, Vol.414, p.132411, Article 132411</ispartof><rights>2024 The Author(s)</rights><rights>Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c287t-e0378cbb6ab0924f1a2e879a9e3ddb52e5f57d8b3bc3720f7d68cf0893a634943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2024.132411$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39094635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Ferrari, Tommaso</creatorcontrib><creatorcontrib>Pistelli, Lorenzo</creatorcontrib><creatorcontrib>Franzino, Marco</creatorcontrib><creatorcontrib>Molinero, Agustin Ezequiel</creatorcontrib><creatorcontrib>De Santis, Giulia Azzurra</creatorcontrib><creatorcontrib>Di Carlo, Alessandro</creatorcontrib><creatorcontrib>Vetta, Giampaolo</creatorcontrib><creatorcontrib>Parlavecchio, Antonio</creatorcontrib><creatorcontrib>Fimiani, Luigi</creatorcontrib><creatorcontrib>Picci, Andrea</creatorcontrib><creatorcontrib>Certo, Giuseppe</creatorcontrib><creatorcontrib>Parisi, Francesca</creatorcontrib><creatorcontrib>Venuti, Giuseppe</creatorcontrib><title>MI2AMI-CS: A meta-analysis comparing Impella and IABP outcomes in Acute Myocardial Infarction-related Cardiogenic Shock</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Cardiogenic Shock (CS) complicating acute myocardial infarction (AMI) poses a significant mortality risk, suggesting the opportunity to implement effective mechanical circulatory support strategies. The comparative efficacy of Intra-Aortic Balloon Pump (IABP) and Impella in managing CS-AMI remains a subject of investigation.
This meta-analysis aims to evaluate the comparative effectiveness of Impella and IABP in managing CS-AMI, exploring mortality and adverse events.
A systematic search of major databases from inception to November 2023 identified eight studies, comprising 10,628 patients, comparing Impella and IABP in CS-AMI. Retrospective studies (preferably Propensity-matched) and Randomized Clinical Trials (RCTs) were included.
Impella use exhibited significantly higher mortality (57% vs. 46%; OR: 1.44, 95% CI: 1.29–1.60; p < 0.001) and major bleeding (30% vs 15%; OR: 2.93, 95% CI: 1.67–5.13; p < 0.001).
In unselected CS-AMI patients, Impella usage is associated with significantly higher mortality and major bleeding.
[Display omitted]
•In unselected patients with AMI complicated by CS, use of Impella is burdened by higher mortality compared to IABP.•Higher mortality with Impella is likely attributable to increased rate of major bleeding and renal complications.•Since not all patients benefit from Impella, its usage should be tailored to the patient clinical presentation.</description><subject>Acute myocardial infarction</subject><subject>Adverse events</subject><subject>Cardiogenic shock</subject><subject>Impella</subject><subject>Intra-aortic balloon pump</subject><subject>Major bleeding</subject><subject>Mortality</subject><subject>Percutaneous mechanical circulatory support</subject><issn>0167-5273</issn><issn>1874-1754</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kMuO1DAQRS0EYpqBP0DISzZp_Epss0DKtHhEmhZIA2vLsSuDmyRu7ATUf0-iDCxZ1aLOrcdB6CUle0po9ea0Dydnk98zwsSeciYofYR2VElRUFmKx2i3YLIomeRX6FnOJ0KI0Fo9RVdcEy0qXu7Q72PD6mNTHO7e4hoPMNnCjra_5JCxi8PZpjDe42Y4Q99bbEePm_rmC47ztHQh4zDi2s0T4OMlrtcE2-Nm7GxyU4hjkaC3E3h8WFvxHsbg8N336H48R08622d48VCv0bcP778ePhW3nz82h_q2cEzJqQDCpXJtW9mWaCY6ahkoqa0G7n1bMii7UnrV8tZxyUgnfaVcR5TmtuJCC36NXm9zzyn-nCFPZgjZrc-MEOdsOFGyrFglyIKKDXUp5pygM-cUBpsuhhKzKjcnsyk3q3KzKV9irx42zO0A_l_or-MFeLcBsPz5K0Ay2QUYHfiQwE3Gx_D_DX8AK-iTXQ</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>De Ferrari, Tommaso</creator><creator>Pistelli, Lorenzo</creator><creator>Franzino, Marco</creator><creator>Molinero, Agustin Ezequiel</creator><creator>De Santis, Giulia Azzurra</creator><creator>Di Carlo, Alessandro</creator><creator>Vetta, Giampaolo</creator><creator>Parlavecchio, Antonio</creator><creator>Fimiani, Luigi</creator><creator>Picci, Andrea</creator><creator>Certo, Giuseppe</creator><creator>Parisi, Francesca</creator><creator>Venuti, Giuseppe</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241101</creationdate><title>MI2AMI-CS: A meta-analysis comparing Impella and IABP outcomes in Acute Myocardial Infarction-related Cardiogenic Shock</title><author>De Ferrari, Tommaso ; Pistelli, Lorenzo ; Franzino, Marco ; Molinero, Agustin Ezequiel ; De Santis, Giulia Azzurra ; Di Carlo, Alessandro ; Vetta, Giampaolo ; Parlavecchio, Antonio ; Fimiani, Luigi ; Picci, Andrea ; Certo, Giuseppe ; Parisi, Francesca ; Venuti, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-e0378cbb6ab0924f1a2e879a9e3ddb52e5f57d8b3bc3720f7d68cf0893a634943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute myocardial infarction</topic><topic>Adverse events</topic><topic>Cardiogenic shock</topic><topic>Impella</topic><topic>Intra-aortic balloon pump</topic><topic>Major bleeding</topic><topic>Mortality</topic><topic>Percutaneous mechanical circulatory support</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Ferrari, Tommaso</creatorcontrib><creatorcontrib>Pistelli, Lorenzo</creatorcontrib><creatorcontrib>Franzino, Marco</creatorcontrib><creatorcontrib>Molinero, Agustin Ezequiel</creatorcontrib><creatorcontrib>De Santis, Giulia Azzurra</creatorcontrib><creatorcontrib>Di Carlo, Alessandro</creatorcontrib><creatorcontrib>Vetta, Giampaolo</creatorcontrib><creatorcontrib>Parlavecchio, Antonio</creatorcontrib><creatorcontrib>Fimiani, Luigi</creatorcontrib><creatorcontrib>Picci, Andrea</creatorcontrib><creatorcontrib>Certo, Giuseppe</creatorcontrib><creatorcontrib>Parisi, Francesca</creatorcontrib><creatorcontrib>Venuti, Giuseppe</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Ferrari, Tommaso</au><au>Pistelli, Lorenzo</au><au>Franzino, Marco</au><au>Molinero, Agustin Ezequiel</au><au>De Santis, Giulia Azzurra</au><au>Di Carlo, Alessandro</au><au>Vetta, Giampaolo</au><au>Parlavecchio, Antonio</au><au>Fimiani, Luigi</au><au>Picci, Andrea</au><au>Certo, Giuseppe</au><au>Parisi, Francesca</au><au>Venuti, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MI2AMI-CS: A meta-analysis comparing Impella and IABP outcomes in Acute Myocardial Infarction-related Cardiogenic Shock</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>414</volume><spage>132411</spage><pages>132411-</pages><artnum>132411</artnum><issn>0167-5273</issn><issn>1874-1754</issn><eissn>1874-1754</eissn><abstract>Cardiogenic Shock (CS) complicating acute myocardial infarction (AMI) poses a significant mortality risk, suggesting the opportunity to implement effective mechanical circulatory support strategies. The comparative efficacy of Intra-Aortic Balloon Pump (IABP) and Impella in managing CS-AMI remains a subject of investigation.
This meta-analysis aims to evaluate the comparative effectiveness of Impella and IABP in managing CS-AMI, exploring mortality and adverse events.
A systematic search of major databases from inception to November 2023 identified eight studies, comprising 10,628 patients, comparing Impella and IABP in CS-AMI. Retrospective studies (preferably Propensity-matched) and Randomized Clinical Trials (RCTs) were included.
Impella use exhibited significantly higher mortality (57% vs. 46%; OR: 1.44, 95% CI: 1.29–1.60; p < 0.001) and major bleeding (30% vs 15%; OR: 2.93, 95% CI: 1.67–5.13; p < 0.001).
In unselected CS-AMI patients, Impella usage is associated with significantly higher mortality and major bleeding.
[Display omitted]
•In unselected patients with AMI complicated by CS, use of Impella is burdened by higher mortality compared to IABP.•Higher mortality with Impella is likely attributable to increased rate of major bleeding and renal complications.•Since not all patients benefit from Impella, its usage should be tailored to the patient clinical presentation.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39094635</pmid><doi>10.1016/j.ijcard.2024.132411</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acute myocardial infarction Adverse events Cardiogenic shock Impella Intra-aortic balloon pump Major bleeding Mortality Percutaneous mechanical circulatory support |
| title | MI2AMI-CS: A meta-analysis comparing Impella and IABP outcomes in Acute Myocardial Infarction-related Cardiogenic Shock |
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