Gastrodin exerts perioperative myocardial protection by improving mitophagy through the PINK1/Parkin pathway to reduce myocardial ischemia-reperfusion injury

•We hypothesized that GAS could repair mitochondrial damage and regulate autophagy.•Male C57BL/6 mice and H9C2 cells survived in I/R and H/R injury after GAS treatment.•MI area diminished and cardiac function improved in GAS-treated mice with MIRI.•Viability increased and cardiomyocyte injury was al...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-10, Vol.133, p.155900, Article 155900
Hauptverfasser:	Chen, Lu, Lv, Yong, Wu, Huiliang, Wang, Yanting, Xu, Zhenzhen, Liu, Guoyang, He, Yuyao, Li, Xia, Liu, Jie, Feng, Yiqi, Bai, Yunxiao, Xie, Wanli, Zhou, Quanjun, Wu, Qingping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Benzyl Alcohols - pharmacology Cardiotonic Agents - pharmacology Cell Line Disease Models, Animal Gastrodin Glucosides - pharmacology Humans Male Mice Mice, Inbred C57BL Mitochondria Mitophagy - drug effects Myocardial Infarction - drug therapy Myocardial ischemia-reperfusion Myocardial Reperfusion Injury - drug therapy Myocardium - metabolism Myocytes, Cardiac - drug effects Perioperative myocardial protection Protein Kinases - metabolism Ubiquitin-Protein Ligases - metabolism
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