Design, synthesis and biological evaluation of glucose metabolism inhibitors as anticancer agents

[Display omitted] •The potential protein target of BH10 was identified via avidin pull-down assays.•A library of novel naphthoimidazole derivatives was successfully synthesized.•The most potent compound 4d exhibited 4 times higher anticancer activity than the lead compound. Compared to normal cells,...

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Veröffentlicht in:	Bioorganic chemistry 2024-10, Vol.151, p.107665, Article 107665
Hauptverfasser:	Cheng, Yao, Jones, John Patrick, Yu, Tsz Tin, Olzomer, Ellen M., Su, Jacky, Katen, Alice, Black, David StC, Hart-Smith, Gene, Childress, Elizabeth S., Wilkins, Marc R., Mateos, Isabel A., Santos, Webster L., Hoehn, Kyle L., Byrne, Frances L., Kumar, Naresh
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer Glycolysis Naphthoimidazole Pharmacokinetic Pull-down assay
Online-Zugang:	Volltext
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