Limbal graft transplantation: a rare implementation in pediatric limbal stem cell deficiency
Purpose To evaluate limbal graft transplantation success in pediatric patients with chemical injury-induced limbal stem cell deficiency (LSCD) using the ‘LSCD Working Group’ staging system. Methods Medical records of 11 eyes of 11 children who underwent limbal graft transplantation (limbal autograft...
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| Veröffentlicht in: | International ophthalmology 2024-08, Vol.44 (1), p.337, Article 337 |
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| creator | Korkmaz, Ilayda Palamar, Melis Timarci, Ilgin Egrilmez, Sait Yagci, Ayse Barut Selver, Ozlem |
| description | Purpose
To evaluate limbal graft transplantation success in pediatric patients with chemical injury-induced limbal stem cell deficiency (LSCD) using the ‘LSCD Working Group’ staging system.
Methods
Medical records of 11 eyes of 11 children who underwent limbal graft transplantation (limbal autograft/limbal allograft) were included. Surgical success was defined as improvement in the post-operative 1st year LSCD stage.
Results
The mean age was 12 ± 5 (4–17) years. Causative agent was alkaline in 4(36.4%) and acid in 3(27.2%) patients. Limbal autograft was performed in 9 (81.8%) eyes with unilateral LSCD, and allograft transplantation was performed in 2 (18.2%) eyes with bilateral LSCD. The mean follow-up time was 33.89 ± 30.73 (12–102.33) months. The overall limbal graft transplantation success rate was 72.7%. Among 9 patients who receive limbal autograft, 8 had improvement in post-operative LSCD stage, 1 had stable LSCD stage. Of the 2 patients who receive limbal allograft, post-operative LSCD stage remained the same in 1 and worsened in 1 patient. The mean time between injury and the surgery was 30.47 ± 30.08 (7–108.47) months. Penetrating keratoplasty was performed in 3 (27.2%) of 11 patients following limbal graft transplantation.
Conclusion
Management of LSCD in children is challenging and appears to be somewhat different from that of adults. Limited data in the literature indicate that cultivated or simple limbal epithelial transplantations (CLET/SLET) are primarily preferred in children. Although the tendency to take small tissue from the healthy eye is noteworthy, conventional limbal allograft and autograft transplantations also show promising results without any further complications in at least 1 year follow-up period. |
| doi_str_mv | 10.1007/s10792-024-03269-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3087357578</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3087442931</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-8ce88a1a3442a3152ccc352dbbb2019633c9b638f48fc6b566533858161f1ceb3</originalsourceid><addsrcrecordid>eNp9kMtOAyEUhonR2Fp9AReGxI2bUeAUBtyZxlvSxI3uTAjDMA3N3ISZRd_eaade4sIVBL7znz8fQueUXFNC0ptISapYQtg8IcCESvgBmlKeQsIEkMNf9wk6iXFNCFGpEsdoAooo4DSdovelrzJT4lUwRYe7YOrYlqbuTOeb-hYbHExw2Fdt6Sq3f8a-xq3LvemCt7gcA2LnKmxdWeLcFd56V9vNKToqTBnd2f6cobeH-9fFU7J8eXxe3C0Ty7joEmmdlIYamM-ZAcqZtRY4y7MsY4QqAWBVJkAWc1lYkXEhOIDkkgpaUOsymKGrMbcNzUfvYqcrH7ddTO2aPmogMgWe8lQO6OUfdN30oR7a7aihgQI6UGykbGhiDK7QbfCVCRtNid6616N7PbjXO_eaD0MX--g-q1z-PfIlewBgBOLwVa9c-Nn9T-wnDyKOsQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3087442931</pqid></control><display><type>article</type><title>Limbal graft transplantation: a rare implementation in pediatric limbal stem cell deficiency</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Korkmaz, Ilayda ; Palamar, Melis ; Timarci, Ilgin ; Egrilmez, Sait ; Yagci, Ayse ; Barut Selver, Ozlem</creator><creatorcontrib>Korkmaz, Ilayda ; Palamar, Melis ; Timarci, Ilgin ; Egrilmez, Sait ; Yagci, Ayse ; Barut Selver, Ozlem</creatorcontrib><description>Purpose
To evaluate limbal graft transplantation success in pediatric patients with chemical injury-induced limbal stem cell deficiency (LSCD) using the ‘LSCD Working Group’ staging system.
Methods
Medical records of 11 eyes of 11 children who underwent limbal graft transplantation (limbal autograft/limbal allograft) were included. Surgical success was defined as improvement in the post-operative 1st year LSCD stage.
Results
The mean age was 12 ± 5 (4–17) years. Causative agent was alkaline in 4(36.4%) and acid in 3(27.2%) patients. Limbal autograft was performed in 9 (81.8%) eyes with unilateral LSCD, and allograft transplantation was performed in 2 (18.2%) eyes with bilateral LSCD. The mean follow-up time was 33.89 ± 30.73 (12–102.33) months. The overall limbal graft transplantation success rate was 72.7%. Among 9 patients who receive limbal autograft, 8 had improvement in post-operative LSCD stage, 1 had stable LSCD stage. Of the 2 patients who receive limbal allograft, post-operative LSCD stage remained the same in 1 and worsened in 1 patient. The mean time between injury and the surgery was 30.47 ± 30.08 (7–108.47) months. Penetrating keratoplasty was performed in 3 (27.2%) of 11 patients following limbal graft transplantation.
Conclusion
Management of LSCD in children is challenging and appears to be somewhat different from that of adults. Limited data in the literature indicate that cultivated or simple limbal epithelial transplantations (CLET/SLET) are primarily preferred in children. Although the tendency to take small tissue from the healthy eye is noteworthy, conventional limbal allograft and autograft transplantations also show promising results without any further complications in at least 1 year follow-up period.</description><identifier>ISSN: 1573-2630</identifier><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-024-03269-5</identifier><identifier>PMID: 39093517</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adolescent ; Allografts ; Autografts ; Burns, Chemical - surgery ; Child ; Child, Preschool ; Children ; Corneal Diseases - surgery ; Corneal transplantation ; Corneal Transplantation - methods ; Eye Burns - chemically induced ; Eye Burns - diagnosis ; Eye Burns - surgery ; Female ; Follow-Up Studies ; Grafting ; Humans ; Injury prevention ; Limbal Stem Cell Deficiency ; Limbus Corneae - cytology ; Male ; Medical records ; Medicine ; Medicine & Public Health ; Ophthalmology ; Original Paper ; Patients ; Pediatrics ; Retrospective Studies ; Stem Cell Transplantation - methods ; Stem cells ; Stem Cells - cytology ; Success ; Transplantation ; Transplantation, Autologous ; Treatment Outcome ; Visual Acuity</subject><ispartof>International ophthalmology, 2024-08, Vol.44 (1), p.337, Article 337</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-8ce88a1a3442a3152ccc352dbbb2019633c9b638f48fc6b566533858161f1ceb3</cites><orcidid>0000-0002-1135-6657 ; 0000-0001-8043-8632 ; 0000-0002-2494-0131 ; 0000-0002-5278-4607 ; 0000-0002-6971-527X ; 0000-0003-3333-3349</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-024-03269-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-024-03269-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39093517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Korkmaz, Ilayda</creatorcontrib><creatorcontrib>Palamar, Melis</creatorcontrib><creatorcontrib>Timarci, Ilgin</creatorcontrib><creatorcontrib>Egrilmez, Sait</creatorcontrib><creatorcontrib>Yagci, Ayse</creatorcontrib><creatorcontrib>Barut Selver, Ozlem</creatorcontrib><title>Limbal graft transplantation: a rare implementation in pediatric limbal stem cell deficiency</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To evaluate limbal graft transplantation success in pediatric patients with chemical injury-induced limbal stem cell deficiency (LSCD) using the ‘LSCD Working Group’ staging system.
Methods
Medical records of 11 eyes of 11 children who underwent limbal graft transplantation (limbal autograft/limbal allograft) were included. Surgical success was defined as improvement in the post-operative 1st year LSCD stage.
Results
The mean age was 12 ± 5 (4–17) years. Causative agent was alkaline in 4(36.4%) and acid in 3(27.2%) patients. Limbal autograft was performed in 9 (81.8%) eyes with unilateral LSCD, and allograft transplantation was performed in 2 (18.2%) eyes with bilateral LSCD. The mean follow-up time was 33.89 ± 30.73 (12–102.33) months. The overall limbal graft transplantation success rate was 72.7%. Among 9 patients who receive limbal autograft, 8 had improvement in post-operative LSCD stage, 1 had stable LSCD stage. Of the 2 patients who receive limbal allograft, post-operative LSCD stage remained the same in 1 and worsened in 1 patient. The mean time between injury and the surgery was 30.47 ± 30.08 (7–108.47) months. Penetrating keratoplasty was performed in 3 (27.2%) of 11 patients following limbal graft transplantation.
Conclusion
Management of LSCD in children is challenging and appears to be somewhat different from that of adults. Limited data in the literature indicate that cultivated or simple limbal epithelial transplantations (CLET/SLET) are primarily preferred in children. Although the tendency to take small tissue from the healthy eye is noteworthy, conventional limbal allograft and autograft transplantations also show promising results without any further complications in at least 1 year follow-up period.</description><subject>Adolescent</subject><subject>Allografts</subject><subject>Autografts</subject><subject>Burns, Chemical - surgery</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Corneal Diseases - surgery</subject><subject>Corneal transplantation</subject><subject>Corneal Transplantation - methods</subject><subject>Eye Burns - chemically induced</subject><subject>Eye Burns - diagnosis</subject><subject>Eye Burns - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Grafting</subject><subject>Humans</subject><subject>Injury prevention</subject><subject>Limbal Stem Cell Deficiency</subject><subject>Limbus Corneae - cytology</subject><subject>Male</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Stem Cell Transplantation - methods</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><subject>Success</subject><subject>Transplantation</subject><subject>Transplantation, Autologous</subject><subject>Treatment Outcome</subject><subject>Visual Acuity</subject><issn>1573-2630</issn><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOAyEUhonR2Fp9AReGxI2bUeAUBtyZxlvSxI3uTAjDMA3N3ISZRd_eaade4sIVBL7znz8fQueUXFNC0ptISapYQtg8IcCESvgBmlKeQsIEkMNf9wk6iXFNCFGpEsdoAooo4DSdovelrzJT4lUwRYe7YOrYlqbuTOeb-hYbHExw2Fdt6Sq3f8a-xq3LvemCt7gcA2LnKmxdWeLcFd56V9vNKToqTBnd2f6cobeH-9fFU7J8eXxe3C0Ty7joEmmdlIYamM-ZAcqZtRY4y7MsY4QqAWBVJkAWc1lYkXEhOIDkkgpaUOsymKGrMbcNzUfvYqcrH7ddTO2aPmogMgWe8lQO6OUfdN30oR7a7aihgQI6UGykbGhiDK7QbfCVCRtNid6616N7PbjXO_eaD0MX--g-q1z-PfIlewBgBOLwVa9c-Nn9T-wnDyKOsQ</recordid><startdate>20240802</startdate><enddate>20240802</enddate><creator>Korkmaz, Ilayda</creator><creator>Palamar, Melis</creator><creator>Timarci, Ilgin</creator><creator>Egrilmez, Sait</creator><creator>Yagci, Ayse</creator><creator>Barut Selver, Ozlem</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1135-6657</orcidid><orcidid>https://orcid.org/0000-0001-8043-8632</orcidid><orcidid>https://orcid.org/0000-0002-2494-0131</orcidid><orcidid>https://orcid.org/0000-0002-5278-4607</orcidid><orcidid>https://orcid.org/0000-0002-6971-527X</orcidid><orcidid>https://orcid.org/0000-0003-3333-3349</orcidid></search><sort><creationdate>20240802</creationdate><title>Limbal graft transplantation: a rare implementation in pediatric limbal stem cell deficiency</title><author>Korkmaz, Ilayda ; Palamar, Melis ; Timarci, Ilgin ; Egrilmez, Sait ; Yagci, Ayse ; Barut Selver, Ozlem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-8ce88a1a3442a3152ccc352dbbb2019633c9b638f48fc6b566533858161f1ceb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Allografts</topic><topic>Autografts</topic><topic>Burns, Chemical - surgery</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Corneal Diseases - surgery</topic><topic>Corneal transplantation</topic><topic>Corneal Transplantation - methods</topic><topic>Eye Burns - chemically induced</topic><topic>Eye Burns - diagnosis</topic><topic>Eye Burns - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Grafting</topic><topic>Humans</topic><topic>Injury prevention</topic><topic>Limbal Stem Cell Deficiency</topic><topic>Limbus Corneae - cytology</topic><topic>Male</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>Stem Cell Transplantation - methods</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><topic>Success</topic><topic>Transplantation</topic><topic>Transplantation, Autologous</topic><topic>Treatment Outcome</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Korkmaz, Ilayda</creatorcontrib><creatorcontrib>Palamar, Melis</creatorcontrib><creatorcontrib>Timarci, Ilgin</creatorcontrib><creatorcontrib>Egrilmez, Sait</creatorcontrib><creatorcontrib>Yagci, Ayse</creatorcontrib><creatorcontrib>Barut Selver, Ozlem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Korkmaz, Ilayda</au><au>Palamar, Melis</au><au>Timarci, Ilgin</au><au>Egrilmez, Sait</au><au>Yagci, Ayse</au><au>Barut Selver, Ozlem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Limbal graft transplantation: a rare implementation in pediatric limbal stem cell deficiency</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2024-08-02</date><risdate>2024</risdate><volume>44</volume><issue>1</issue><spage>337</spage><pages>337-</pages><artnum>337</artnum><issn>1573-2630</issn><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To evaluate limbal graft transplantation success in pediatric patients with chemical injury-induced limbal stem cell deficiency (LSCD) using the ‘LSCD Working Group’ staging system.
Methods
Medical records of 11 eyes of 11 children who underwent limbal graft transplantation (limbal autograft/limbal allograft) were included. Surgical success was defined as improvement in the post-operative 1st year LSCD stage.
Results
The mean age was 12 ± 5 (4–17) years. Causative agent was alkaline in 4(36.4%) and acid in 3(27.2%) patients. Limbal autograft was performed in 9 (81.8%) eyes with unilateral LSCD, and allograft transplantation was performed in 2 (18.2%) eyes with bilateral LSCD. The mean follow-up time was 33.89 ± 30.73 (12–102.33) months. The overall limbal graft transplantation success rate was 72.7%. Among 9 patients who receive limbal autograft, 8 had improvement in post-operative LSCD stage, 1 had stable LSCD stage. Of the 2 patients who receive limbal allograft, post-operative LSCD stage remained the same in 1 and worsened in 1 patient. The mean time between injury and the surgery was 30.47 ± 30.08 (7–108.47) months. Penetrating keratoplasty was performed in 3 (27.2%) of 11 patients following limbal graft transplantation.
Conclusion
Management of LSCD in children is challenging and appears to be somewhat different from that of adults. Limited data in the literature indicate that cultivated or simple limbal epithelial transplantations (CLET/SLET) are primarily preferred in children. Although the tendency to take small tissue from the healthy eye is noteworthy, conventional limbal allograft and autograft transplantations also show promising results without any further complications in at least 1 year follow-up period.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>39093517</pmid><doi>10.1007/s10792-024-03269-5</doi><orcidid>https://orcid.org/0000-0002-1135-6657</orcidid><orcidid>https://orcid.org/0000-0001-8043-8632</orcidid><orcidid>https://orcid.org/0000-0002-2494-0131</orcidid><orcidid>https://orcid.org/0000-0002-5278-4607</orcidid><orcidid>https://orcid.org/0000-0002-6971-527X</orcidid><orcidid>https://orcid.org/0000-0003-3333-3349</orcidid></addata></record> |
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| subjects | Adolescent Allografts Autografts Burns, Chemical - surgery Child Child, Preschool Children Corneal Diseases - surgery Corneal transplantation Corneal Transplantation - methods Eye Burns - chemically induced Eye Burns - diagnosis Eye Burns - surgery Female Follow-Up Studies Grafting Humans Injury prevention Limbal Stem Cell Deficiency Limbus Corneae - cytology Male Medical records Medicine Medicine & Public Health Ophthalmology Original Paper Patients Pediatrics Retrospective Studies Stem Cell Transplantation - methods Stem cells Stem Cells - cytology Success Transplantation Transplantation, Autologous Treatment Outcome Visual Acuity |
| title | Limbal graft transplantation: a rare implementation in pediatric limbal stem cell deficiency |
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