Predictive value of neutrophil‐to‐lymphocyte ratio on admission for intrapartum maternal fever in parturients undergoing epidural analgesia: A retrospective cohort study using propensity score‐matched analysis
Objective To identify the predictive value of the neutrophil‐to‐lymphocyte ratio (NLR) on admission for intrapartum maternal fever in parturients undergoing epidural analgesia (EA). Methods In this retrospective cohort study, propensity score matching (PSM) was applied to address covariates. Univari...
Gespeichert in:
| Veröffentlicht in: | International journal of gynecology and obstetrics 2025-01, Vol.168 (1), p.167-176 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 176 |
|---|---|
| container_issue | 1 |
| container_start_page | 167 |
| container_title | International journal of gynecology and obstetrics |
| container_volume | 168 |
| creator | Li, Kunyue Deng, Chunyun Sun, Daqi Wang, Yuxia Li, Genxia Jiang, Lihua Wang, Tao |
| description | Objective
To identify the predictive value of the neutrophil‐to‐lymphocyte ratio (NLR) on admission for intrapartum maternal fever in parturients undergoing epidural analgesia (EA).
Methods
In this retrospective cohort study, propensity score matching (PSM) was applied to address covariates. Univariate and multivariate regression analyses were implemented in sequence to find out the factors influencing intrapartum fever. The receiver operating characteristics curve was applied to determine the area under the curve (AUC) of NLR for intrapartum fever.
Results
NLR and duration of EA were independent risk factors for intrapartum fever. The AUC of the combined indicator (NLR + duration of EA) was higher than that of NLR (AUC = 0.583, 95% confidence interval [CI] 0.53–0.64) and duration of EA (AUC = 0.702, 95% CI 0.66–0.75), reaching 0.715 (95% CI 0.67–0.76; p |
| doi_str_mv | 10.1002/ijgo.15820 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3087356435</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3087356435</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2180-6768d7c8e426edf426d00ad4c7e3a3c4bf56b6f813a85302214c961879a0cd013</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS1ERYfChgdAXiKktP5J4oRdVUEpqlQWsI489s2Mq8QO_hmUHY_A27HnSXAmbZdsri3dz-ce34PQG0rOKSHswtzv3DmtGkaeoQ1tRFvwUrTP0SY3SSFYy07RyxDuCSFUUPoCnfKWtKwS1Qb9-epBGxXNAfBBDgmw67GFFL2b9mb4--t3dLkM8zjtnZojYC-jcdhZLPVoQjD51juPjY1eTtLHNOJRRvBWDriHAywtfGx4AzYGnKwGv3PG7jBMRiefQZnpHQQjP-BL7CFPDxOsrpTbOx9xiEnPOIXl2ZTNgQ0mzjgo5yEbzCPVHvRRaA4mvEInvRwCvH44z9D3Tx-_XX0ubu-ub64ubwvFaEOKWtSNFqqBktWg-1w1IVKXSgCXXJXbvqq3dd9QLpuKE8Zoqdp62bEkShPKz9C7VTd7-pEgxC4vRcEwSAsuhY6TRvCqLnmV0fcrqvLvgoe-m7wZpZ87SrolyG4JsjsGmeG3D7ppO4J-Qh-TywBdgZ9mgPk_Ut3Nl-u7VfQfKD2zWw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3087356435</pqid></control><display><type>article</type><title>Predictive value of neutrophil‐to‐lymphocyte ratio on admission for intrapartum maternal fever in parturients undergoing epidural analgesia: A retrospective cohort study using propensity score‐matched analysis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Li, Kunyue ; Deng, Chunyun ; Sun, Daqi ; Wang, Yuxia ; Li, Genxia ; Jiang, Lihua ; Wang, Tao</creator><creatorcontrib>Li, Kunyue ; Deng, Chunyun ; Sun, Daqi ; Wang, Yuxia ; Li, Genxia ; Jiang, Lihua ; Wang, Tao</creatorcontrib><description>Objective
To identify the predictive value of the neutrophil‐to‐lymphocyte ratio (NLR) on admission for intrapartum maternal fever in parturients undergoing epidural analgesia (EA).
Methods
In this retrospective cohort study, propensity score matching (PSM) was applied to address covariates. Univariate and multivariate regression analyses were implemented in sequence to find out the factors influencing intrapartum fever. The receiver operating characteristics curve was applied to determine the area under the curve (AUC) of NLR for intrapartum fever.
Results
NLR and duration of EA were independent risk factors for intrapartum fever. The AUC of the combined indicator (NLR + duration of EA) was higher than that of NLR (AUC = 0.583, 95% confidence interval [CI] 0.53–0.64) and duration of EA (AUC = 0.702, 95% CI 0.66–0.75), reaching 0.715 (95% CI 0.67–0.76; p < 0.001). NLR increased predictive performance for intrapartum fever when added to the duration of EA (net reclassification index 0.076, p = 0.022; integrated discrimination improvement 0.020, p = 0.002).
Conclusion
NLR has limited predictive power for intrapartum fever. The combination of NLR and duration of epidural analgesia may be considered a promising predictor for intrapartum maternal fever in parturients undergoing epidural analgesia.
Synopsis
The neutrophil‐to‐lymphocyte ratio is an accessible predictor for the early identification of parturients at risk of intrapartum fever.
Synopsis
The neutrophil‐to‐lymphocyte ratio is an accessible predictor for the early identification of parturients at risk of intrapartum fever.</description><identifier>ISSN: 0020-7292</identifier><identifier>ISSN: 1879-3479</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1002/ijgo.15820</identifier><identifier>PMID: 39092575</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Analgesia, Epidural ; Analgesia, Obstetrical - methods ; duration of epidural analgesia ; epidural analgesia ; epidural‐associated maternal fever ; Female ; Fever - etiology ; Humans ; inflammation ; intrapartum maternal fever ; labor analgesia ; Lymphocyte Count ; Lymphocytes ; Neutrophils ; neutrophil‐to‐lymphocyte ratio ; Predictive Value of Tests ; Pregnancy ; Propensity Score ; Retrospective Studies ; Risk Factors ; ROC Curve</subject><ispartof>International journal of gynecology and obstetrics, 2025-01, Vol.168 (1), p.167-176</ispartof><rights>2024 International Federation of Gynecology and Obstetrics.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2180-6768d7c8e426edf426d00ad4c7e3a3c4bf56b6f813a85302214c961879a0cd013</cites><orcidid>0000-0003-0789-6201 ; 0009-0004-3672-9407</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijgo.15820$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijgo.15820$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39092575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Kunyue</creatorcontrib><creatorcontrib>Deng, Chunyun</creatorcontrib><creatorcontrib>Sun, Daqi</creatorcontrib><creatorcontrib>Wang, Yuxia</creatorcontrib><creatorcontrib>Li, Genxia</creatorcontrib><creatorcontrib>Jiang, Lihua</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><title>Predictive value of neutrophil‐to‐lymphocyte ratio on admission for intrapartum maternal fever in parturients undergoing epidural analgesia: A retrospective cohort study using propensity score‐matched analysis</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Objective
To identify the predictive value of the neutrophil‐to‐lymphocyte ratio (NLR) on admission for intrapartum maternal fever in parturients undergoing epidural analgesia (EA).
Methods
In this retrospective cohort study, propensity score matching (PSM) was applied to address covariates. Univariate and multivariate regression analyses were implemented in sequence to find out the factors influencing intrapartum fever. The receiver operating characteristics curve was applied to determine the area under the curve (AUC) of NLR for intrapartum fever.
Results
NLR and duration of EA were independent risk factors for intrapartum fever. The AUC of the combined indicator (NLR + duration of EA) was higher than that of NLR (AUC = 0.583, 95% confidence interval [CI] 0.53–0.64) and duration of EA (AUC = 0.702, 95% CI 0.66–0.75), reaching 0.715 (95% CI 0.67–0.76; p < 0.001). NLR increased predictive performance for intrapartum fever when added to the duration of EA (net reclassification index 0.076, p = 0.022; integrated discrimination improvement 0.020, p = 0.002).
Conclusion
NLR has limited predictive power for intrapartum fever. The combination of NLR and duration of epidural analgesia may be considered a promising predictor for intrapartum maternal fever in parturients undergoing epidural analgesia.
Synopsis
The neutrophil‐to‐lymphocyte ratio is an accessible predictor for the early identification of parturients at risk of intrapartum fever.
Synopsis
The neutrophil‐to‐lymphocyte ratio is an accessible predictor for the early identification of parturients at risk of intrapartum fever.</description><subject>Adult</subject><subject>Analgesia, Epidural</subject><subject>Analgesia, Obstetrical - methods</subject><subject>duration of epidural analgesia</subject><subject>epidural analgesia</subject><subject>epidural‐associated maternal fever</subject><subject>Female</subject><subject>Fever - etiology</subject><subject>Humans</subject><subject>inflammation</subject><subject>intrapartum maternal fever</subject><subject>labor analgesia</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Neutrophils</subject><subject>neutrophil‐to‐lymphocyte ratio</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Propensity Score</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><issn>0020-7292</issn><issn>1879-3479</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS1ERYfChgdAXiKktP5J4oRdVUEpqlQWsI489s2Mq8QO_hmUHY_A27HnSXAmbZdsri3dz-ce34PQG0rOKSHswtzv3DmtGkaeoQ1tRFvwUrTP0SY3SSFYy07RyxDuCSFUUPoCnfKWtKwS1Qb9-epBGxXNAfBBDgmw67GFFL2b9mb4--t3dLkM8zjtnZojYC-jcdhZLPVoQjD51juPjY1eTtLHNOJRRvBWDriHAywtfGx4AzYGnKwGv3PG7jBMRiefQZnpHQQjP-BL7CFPDxOsrpTbOx9xiEnPOIXl2ZTNgQ0mzjgo5yEbzCPVHvRRaA4mvEInvRwCvH44z9D3Tx-_XX0ubu-ub64ubwvFaEOKWtSNFqqBktWg-1w1IVKXSgCXXJXbvqq3dd9QLpuKE8Zoqdp62bEkShPKz9C7VTd7-pEgxC4vRcEwSAsuhY6TRvCqLnmV0fcrqvLvgoe-m7wZpZ87SrolyG4JsjsGmeG3D7ppO4J-Qh-TywBdgZ9mgPk_Ut3Nl-u7VfQfKD2zWw</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Li, Kunyue</creator><creator>Deng, Chunyun</creator><creator>Sun, Daqi</creator><creator>Wang, Yuxia</creator><creator>Li, Genxia</creator><creator>Jiang, Lihua</creator><creator>Wang, Tao</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0789-6201</orcidid><orcidid>https://orcid.org/0009-0004-3672-9407</orcidid></search><sort><creationdate>202501</creationdate><title>Predictive value of neutrophil‐to‐lymphocyte ratio on admission for intrapartum maternal fever in parturients undergoing epidural analgesia: A retrospective cohort study using propensity score‐matched analysis</title><author>Li, Kunyue ; Deng, Chunyun ; Sun, Daqi ; Wang, Yuxia ; Li, Genxia ; Jiang, Lihua ; Wang, Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2180-6768d7c8e426edf426d00ad4c7e3a3c4bf56b6f813a85302214c961879a0cd013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Analgesia, Epidural</topic><topic>Analgesia, Obstetrical - methods</topic><topic>duration of epidural analgesia</topic><topic>epidural analgesia</topic><topic>epidural‐associated maternal fever</topic><topic>Female</topic><topic>Fever - etiology</topic><topic>Humans</topic><topic>inflammation</topic><topic>intrapartum maternal fever</topic><topic>labor analgesia</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Neutrophils</topic><topic>neutrophil‐to‐lymphocyte ratio</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Propensity Score</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Kunyue</creatorcontrib><creatorcontrib>Deng, Chunyun</creatorcontrib><creatorcontrib>Sun, Daqi</creatorcontrib><creatorcontrib>Wang, Yuxia</creatorcontrib><creatorcontrib>Li, Genxia</creatorcontrib><creatorcontrib>Jiang, Lihua</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Kunyue</au><au>Deng, Chunyun</au><au>Sun, Daqi</au><au>Wang, Yuxia</au><au>Li, Genxia</au><au>Jiang, Lihua</au><au>Wang, Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive value of neutrophil‐to‐lymphocyte ratio on admission for intrapartum maternal fever in parturients undergoing epidural analgesia: A retrospective cohort study using propensity score‐matched analysis</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2025-01</date><risdate>2025</risdate><volume>168</volume><issue>1</issue><spage>167</spage><epage>176</epage><pages>167-176</pages><issn>0020-7292</issn><issn>1879-3479</issn><eissn>1879-3479</eissn><abstract>Objective
To identify the predictive value of the neutrophil‐to‐lymphocyte ratio (NLR) on admission for intrapartum maternal fever in parturients undergoing epidural analgesia (EA).
Methods
In this retrospective cohort study, propensity score matching (PSM) was applied to address covariates. Univariate and multivariate regression analyses were implemented in sequence to find out the factors influencing intrapartum fever. The receiver operating characteristics curve was applied to determine the area under the curve (AUC) of NLR for intrapartum fever.
Results
NLR and duration of EA were independent risk factors for intrapartum fever. The AUC of the combined indicator (NLR + duration of EA) was higher than that of NLR (AUC = 0.583, 95% confidence interval [CI] 0.53–0.64) and duration of EA (AUC = 0.702, 95% CI 0.66–0.75), reaching 0.715 (95% CI 0.67–0.76; p < 0.001). NLR increased predictive performance for intrapartum fever when added to the duration of EA (net reclassification index 0.076, p = 0.022; integrated discrimination improvement 0.020, p = 0.002).
Conclusion
NLR has limited predictive power for intrapartum fever. The combination of NLR and duration of epidural analgesia may be considered a promising predictor for intrapartum maternal fever in parturients undergoing epidural analgesia.
Synopsis
The neutrophil‐to‐lymphocyte ratio is an accessible predictor for the early identification of parturients at risk of intrapartum fever.
Synopsis
The neutrophil‐to‐lymphocyte ratio is an accessible predictor for the early identification of parturients at risk of intrapartum fever.</abstract><cop>United States</cop><pmid>39092575</pmid><doi>10.1002/ijgo.15820</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0789-6201</orcidid><orcidid>https://orcid.org/0009-0004-3672-9407</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7292 |
| ispartof | International journal of gynecology and obstetrics, 2025-01, Vol.168 (1), p.167-176 |
| issn | 0020-7292 1879-3479 1879-3479 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3087356435 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Analgesia, Epidural Analgesia, Obstetrical - methods duration of epidural analgesia epidural analgesia epidural‐associated maternal fever Female Fever - etiology Humans inflammation intrapartum maternal fever labor analgesia Lymphocyte Count Lymphocytes Neutrophils neutrophil‐to‐lymphocyte ratio Predictive Value of Tests Pregnancy Propensity Score Retrospective Studies Risk Factors ROC Curve |
| title | Predictive value of neutrophil‐to‐lymphocyte ratio on admission for intrapartum maternal fever in parturients undergoing epidural analgesia: A retrospective cohort study using propensity score‐matched analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T04%3A29%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predictive%20value%20of%20neutrophil%E2%80%90to%E2%80%90lymphocyte%20ratio%20on%20admission%20for%20intrapartum%20maternal%20fever%20in%20parturients%20undergoing%20epidural%20analgesia:%20A%20retrospective%20cohort%20study%20using%20propensity%20score%E2%80%90matched%20analysis&rft.jtitle=International%20journal%20of%20gynecology%20and%20obstetrics&rft.au=Li,%20Kunyue&rft.date=2025-01&rft.volume=168&rft.issue=1&rft.spage=167&rft.epage=176&rft.pages=167-176&rft.issn=0020-7292&rft.eissn=1879-3479&rft_id=info:doi/10.1002/ijgo.15820&rft_dat=%3Cproquest_cross%3E3087356435%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3087356435&rft_id=info:pmid/39092575&rfr_iscdi=true |