RIPK3 causes mitochondrial dysfunction and albuminuria in diabetic podocytopathy through PGAM5-Drp1 signaling

Receptor-interacting protein kinase (RIPK)3 is an essential molecule for necroptosis and its role in kidney fibrosis has been investigated using various kidney injury models. However, the relevance and the underlying mechanisms of RIPK3 to podocyte injury in albuminuric diabetic kidney disease (DKD)...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2024-10, Vol.159, p.155982, Article 155982
Hauptverfasser:	Kang, Jeong Suk, Cho, Nam-Jun, Lee, Seong Woo, Lee, Jeong Geon, Lee, Ji-Hye, Yi, Jawoon, Choi, Min Sun, Park, Samel, Gil, Hyo-Wook, Oh, Joon Cheol, Son, Seung Seob, Park, Mi Ju, Moon, Jong-Seok, Lee, Donghyeong, Kim, So-Young, Yang, Seung-Hoon, Kim, Sang Soo, Lee, Eun Soo, Chung, Choon Hee, Park, Jihwan, Lee, Eun Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria Diabetic kidney disease Drp1 Mitochondrial fission Necroptosis PGAM5 Podocytopathy RIPK3
Online-Zugang:	Volltext
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