A Cytochrome P450 TxtE Model System with Mechanistic and Theoretical Evidence for a Heme Peroxynitrite Active Species

The cytochrome P450 homolog, TxtE, efficiently catalyzes the direct and regioselective aromatic nitration of the indolyl moiety of L‐tryptophan to 4‐nitro‐L‐tryptophan, using nitric oxide (NO) and dioxygen (O2) as co‐substrates. Pathways for such direct and selective nitration of heteroaromatic moti...

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Veröffentlicht in:	Angewandte Chemie International Edition 2024-12, Vol.63 (49), p.e202409430-n/a
Hauptverfasser:	Mondal, Pritam, Udukalage, Dhilanka, Mohamed, Abubaker A., Wong, Henrik P. H., Visser, Sam P., Wijeratne, Gayan B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysts Biomimetics Cytochrome Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Cytochromes P450 Heme Heme - chemistry Heme - metabolism Heme peroxynitrite indole nitration Industrial applications mechanism Molecular Structure Nitration Nitric oxide Nitric Oxide - chemistry Nitric Oxide - metabolism Peroxynitrite Peroxynitrous Acid - chemistry Peroxynitrous Acid - metabolism synthetic heme models Tryptophan Tryptophan - chemistry Tryptophan - metabolism TxtE
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