CD33 Ameliorates Surgery-Induced Spatial Learning and Memory Impairments Through TREM2

Neuroinflammation is implicated in the onset of postoperative cognitive dysfunction (POCD), with CD33 and triggering receptor expressed on myeloid cells 2 (TREM2) playing crucial roles in immune response modulation and neuroinflammatory processes. A total of 96 aged male C57/BL6 mice (9–12 months) w...

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Veröffentlicht in:	Molecular neurobiology 2025-02, Vol.62 (2), p.2180-2190
Hauptverfasser:	Zou, Jie, Wang, Yaxuan, Zhang, Xinyue, Pan, Xue, Fang, Te, Cai, Dasheng, Guo, Lili, Li, Yu, He, Yi, Cao, Xuezhao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell Line Cognitive ability Hepatectomy Hippocampus Hippocampus - metabolism Immune response Immunological memory Immunomodulation Inflammation Male Maze Learning - physiology Membrane Glycoproteins - metabolism Memory Memory Disorders - metabolism Mice Mice, Inbred C57BL Microglia Microglia - metabolism Myeloid cells Neurobiology Neurology Neuromodulation Neurosciences Postoperative Cognitive Complications - metabolism Postoperative Cognitive Complications - prevention & control Receptors, Immunologic - metabolism RNA, Small Interfering - metabolism Sialic Acid Binding Ig-like Lectin 3 - metabolism siRNA Spatial discrimination learning Spatial Learning Spatial memory Surgery Ventricles (cerebral)
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