Current surgical management of chronic thromboembolic pulmonary disease
Chronic thromboembolic pulmonary disease (CTEPD) with or without pulmonary hypertension (PH) is an important potential consequence of venous thromboembolic disease. Untreated CTEPD with pulmonary hypertension (CTEPH) is associated with high rates of morbidity and mortality. Several treatment options...
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| Veröffentlicht in: | Internal medicine journal 2024-10, Vol.54 (10), p.1616-1625 |
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| creator | Barnes, Hayley Niewodowski, Daniel Doi, Atsuo Marasco, Silvana Joseph, Tim Siemienowicz, Miranda Keating, Dominic Yo, Shaun Kaye, David Williams, Trevor McGiffin, David Whitford, Helen |
| description | Chronic thromboembolic pulmonary disease (CTEPD) with or without pulmonary hypertension (PH) is an important potential consequence of venous thromboembolic disease. Untreated CTEPD with pulmonary hypertension (CTEPH) is associated with high rates of morbidity and mortality. Several treatment options are now available for patients with CTEPD and CTEPH, including pulmonary endarterectomy (PEA), balloon pulmonary angioplasty, medical therapy or a combination of therapies. Choice of treatment depends on the location of the thromboembolic disease burden, presence and severity of PH and patient factors, including frailty, parenchymal lung disease and other comorbidities. PEA is a complex surgery that can result in excellent outcomes and resolution of disease, but also comes with the risk of serious perioperative complications. This manuscript examines the history of PEA and its place in Australasia, and reports on outcomes from the main Australasian CTEPH expert centre. It provides a summary of up‐to‐date guidance on how PEA should be utilised in the overall management of these patients and describes opportunities and challenges for the future diagnosis and management of this disease, particularly in the Australasian setting. |
| doi_str_mv | 10.1111/imj.16470 |
| format | Article |
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Untreated CTEPD with pulmonary hypertension (CTEPH) is associated with high rates of morbidity and mortality. Several treatment options are now available for patients with CTEPD and CTEPH, including pulmonary endarterectomy (PEA), balloon pulmonary angioplasty, medical therapy or a combination of therapies. Choice of treatment depends on the location of the thromboembolic disease burden, presence and severity of PH and patient factors, including frailty, parenchymal lung disease and other comorbidities. PEA is a complex surgery that can result in excellent outcomes and resolution of disease, but also comes with the risk of serious perioperative complications. This manuscript examines the history of PEA and its place in Australasia, and reports on outcomes from the main Australasian CTEPH expert centre. 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| subjects | Angioplasty Angioplasty, Balloon - methods Balloon treatment cardiothoracics Chronic Disease Comorbidity Disease management Endarterectomy - methods Humans Hypertension Hypertension, Pulmonary - surgery Lung diseases Medical treatment Morbidity Patients pulmonary embolism Pulmonary Embolism - complications Pulmonary Embolism - surgery Pulmonary hypertension Thromboembolism |
| title | Current surgical management of chronic thromboembolic pulmonary disease |
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