Letter to editor: Beyond nimodipine: advanced neuroprotection strategies for aneurysmal subarachnoid hemorrhage vasospasm and delayed cerebral ischemia
This critique discusses neuroprotective strategies for aneurysmal subarachnoid hemorrhage (SAH), excluding Nimodipine, emphasizing alternatives like verapamil, albumin, and cilostazol. While these options show potential, their efficacy lacks robust confirmation from randomized controlled trials (RCT...
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| Veröffentlicht in: | Neurosurgical review 2024-08, Vol.47 (1), p.383, Article 383 |
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| creator | Rizvi, Syeda Vilay Zehra Zaidi, Syeda Mahrukh Fatima |
| description | This critique discusses neuroprotective strategies for aneurysmal subarachnoid hemorrhage (SAH), excluding Nimodipine, emphasizing alternatives like verapamil, albumin, and cilostazol. While these options show potential, their efficacy lacks robust confirmation from randomized controlled trials (RCTs), relying mainly on observational studies and small trials. The letter underscores the need for comprehensive safety assessments and long-term outcome studies to enhance practical application. Highlighting ongoing trials and emerging therapies like clazosentan and TAK-044, it advocates for future research directions focused on large-scale RCTs and combination therapies, such as cilostazol and Nimodipine, which have demonstrated synergistic benefits in reducing delayed cerebral ischemia (DCI) and improving patient outcomes. |
| doi_str_mv | 10.1007/s10143-024-02617-4 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Neurosurgical review, 2024-08, Vol.47 (1), p.383, Article 383 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Brain Ischemia - drug therapy Brain Ischemia - prevention & control Cilostazol - therapeutic use Correspondence Humans Medicine Medicine & Public Health Neuroprotection - drug effects Neuroprotective Agents - therapeutic use Neurosurgery Nimodipine - therapeutic use Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - drug therapy Vasospasm, Intracranial - drug therapy Vasospasm, Intracranial - etiology Vasospasm, Intracranial - prevention & control |
| title | Letter to editor: Beyond nimodipine: advanced neuroprotection strategies for aneurysmal subarachnoid hemorrhage vasospasm and delayed cerebral ischemia |
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