Evaluation of the adjuvant effect of imiquimod and CpG ODN 1826 in chimeric DNA vaccine against Japanese encephalitis

•IMQ and CpG ODN 1826 as adjuvants enhance JE DNA vaccine immunogenicity and long-term immune response.•IMQ and CpG ODN 1826 exert synergistic effects as adjuvants for the JE DNA vaccine.•Combination of selected TLR agonists may induce stronger and longer lasting immune efficacy than a single adjuva...

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Veröffentlicht in:	International immunopharmacology 2024-10, Vol.140, p.112816, Article 112816
Hauptverfasser:	Zang, Xin, Li, Guozhen, Zhu, Junyao, Dong, Xiaoying, Zhai, Yongzhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - pharmacology Adjuvants, Vaccine - pharmacology Animals DNA vaccine Encephalitis Virus, Japanese - immunology Encephalitis, Japanese - immunology Encephalitis, Japanese - prevention & control Female Humans Imiquimod Innate immunity Japanese encephalitis Japanese Encephalitis Vaccines - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Oligodeoxyribonucleotides - administration & dosage Oligodeoxyribonucleotides - pharmacology Toll-Like Receptor 7 - agonists Toll-Like Receptor 8 - agonists Toll-Like Receptor 9 - agonists Toll-like receptor agonist Vaccines, DNA - immunology
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