Small molecules targeting HDAC6 for cancer treatment: Current progress and novel strategies

Histone deacetylase 6 (HDAC6) plays a crucial role in the initiation and progression of various cancers, as its overexpression is linked to tumor growth, invasion, migration, survival, apoptosis, and angiogenesis. Therefore, HDAC6 has emerged as an attractive target for anticancer drug discovery in...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-09, Vol.178, p.117218, Article 117218
Hauptverfasser:	Huang, Ziqian, Li, Ling, Cheng, Binbin, Li, Deping
Format:	Artikel
Sprache:	eng
Schlagworte:	Bio-function Dual-target inhibitors Histone deacetylase 6 (HDAC6) Selective inhibitors Targeted Protein Degradation (TPD)
Online-Zugang:	Volltext
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