Expanding the toolbox of Baeyer-Villiger and flavin monooxygenase biocatalysts for the enantiodivergent green synthesis of sulfoxides
Two new monooxygenase biocatalysts, the Baeyer-Villiger monooxygenase BVMO145 and the flavin monooxygenase FMO401 from Almac library, have been found to catalyse the enantiodivergent oxidation of sulfides bearing N-heterocyclic substituents into sulfoxides under mild and green conditions. The biocat...
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| Veröffentlicht in: | Green chemistry : an international journal and green chemistry resource : GC 2024-07, Vol.26 (15), p.8685-8693 |
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| container_issue | 15 |
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| container_title | Green chemistry : an international journal and green chemistry resource : GC |
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| creator | Wu, Jingyue Anselmi, Silvia Carvalho, Alexandra T. P Caswell, Jill Quinn, Derek J Moody, Thomas S Castagnolo, Daniele |
| description | Two new monooxygenase biocatalysts, the Baeyer-Villiger monooxygenase BVMO145 and the flavin monooxygenase FMO401 from Almac library, have been found to catalyse the enantiodivergent oxidation of sulfides bearing N-heterocyclic substituents into sulfoxides under mild and green conditions. The biocatalyst BVMO145 provides (
S
)-sulfoxides while the flavin monooxygenase FMO401 affords (
R
)-sulfoxides with good conversions and high ee.
Two new monooxygenase biocatalysts, BVMO145 and FMO401 from Almac library, catalyse the enantiodivergent oxidation of sulfides bearing N-heterocyclic substituents into sulfoxides under mild and green conditions. |
| doi_str_mv | 10.1039/d4gc02657h |
| format | Article |
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S
)-sulfoxides while the flavin monooxygenase FMO401 affords (
R
)-sulfoxides with good conversions and high ee.
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S
)-sulfoxides while the flavin monooxygenase FMO401 affords (
R
)-sulfoxides with good conversions and high ee.
Two new monooxygenase biocatalysts, BVMO145 and FMO401 from Almac library, catalyse the enantiodivergent oxidation of sulfides bearing N-heterocyclic substituents into sulfoxides under mild and green conditions.</description><subject>Biocatalysts</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Flavin</subject><subject>Monooxygenase</subject><subject>Oxidation</subject><subject>Sulfoxides</subject><issn>1463-9262</issn><issn>1463-9270</issn><issn>1463-9262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkktr3DAUhU1paB7tpvsWQTeh4FYvy_IqtNM0KQS6Sbo1snTtUdBIU8kexj-g_7uaTDJ9gECC83HuuRwVxWuCPxDMmo-GDxpTUdXLZ8UJ4YKVDa3x88Nb0OPiNKV7jAmpBX9RHLMGS8IbcVL8utyulTfWD2hcAhpDcF3YotCjzwpmiOUP65wdIKJMod6pjfVoFXwI23kArxKgzgatRuXmNCbUh_hglCU_2mDsBmLmRjREAI_S7LOabNpNSJPrw9YaSC-Lo165BK8e77Pi7uvl7eK6vPl-9W3x6abUjMixNB3hhEpMDZZa9hyowrTraqVNI7GsmWSdNF3FBabQS5EP5lCrisiuaghhZ8XF3nc9dSswOgeLyrXraFcqzm1Qtv1X8XbZDmHTkjyWC8qyw_mjQww_J0hju7JJg3PKQ5hSy7AUOQYjTUbf_Yfehyn6vN-OqhjnshaZer-ndAwpRegPaQhud_W2X_jV4qHe6wy__Tv_AX3qMwNv9kBM-qD--R_sN_fSrUI</recordid><startdate>20240729</startdate><enddate>20240729</enddate><creator>Wu, Jingyue</creator><creator>Anselmi, Silvia</creator><creator>Carvalho, Alexandra T. 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P ; Caswell, Jill ; Quinn, Derek J ; Moody, Thomas S ; Castagnolo, Daniele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-db1412802d08c8f4e2a02bb7acd98087383b8db54602ef86f8604e7a518b59113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biocatalysts</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Flavin</topic><topic>Monooxygenase</topic><topic>Oxidation</topic><topic>Sulfoxides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jingyue</creatorcontrib><creatorcontrib>Anselmi, Silvia</creatorcontrib><creatorcontrib>Carvalho, Alexandra T. 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S
)-sulfoxides while the flavin monooxygenase FMO401 affords (
R
)-sulfoxides with good conversions and high ee.
Two new monooxygenase biocatalysts, BVMO145 and FMO401 from Almac library, catalyse the enantiodivergent oxidation of sulfides bearing N-heterocyclic substituents into sulfoxides under mild and green conditions.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>39081496</pmid><doi>10.1039/d4gc02657h</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9289-5109</orcidid><orcidid>https://orcid.org/0000-0003-2827-5527</orcidid><orcidid>https://orcid.org/0000-0003-3087-7287</orcidid><orcidid>https://orcid.org/0000-0002-7517-5732</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1463-9262 |
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| issn | 1463-9262 1463-9270 1463-9262 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biocatalysts Chemical synthesis Chemistry Flavin Monooxygenase Oxidation Sulfoxides |
| title | Expanding the toolbox of Baeyer-Villiger and flavin monooxygenase biocatalysts for the enantiodivergent green synthesis of sulfoxides |
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