Value of serum muscular creatinine phosphokinase levels in patients with adenomyosis as a non‐invasive diagnostic marker
Objective In the present study, we aimed to compare serum CK‐MM levels in patients with and without adenomyosis and to investigate whether CK‐MM level can be a non‐invasive marker for myometrial damage due to adenomyosis. Materials and Methods Our study was a prospective case‐control study in a tert...
Gespeichert in:
| Veröffentlicht in: | International journal of gynecology and obstetrics 2024-07, Vol.168 (1), p.314-319 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 319 |
|---|---|
| container_issue | 1 |
| container_start_page | 314 |
| container_title | International journal of gynecology and obstetrics |
| container_volume | 168 |
| creator | Bulut Aydemir, Hilal Mürüvvet Kahyaoğlu, Serkan Halilzade, İnci Moraloğlu‐Tekin, Özlem |
| description | Objective
In the present study, we aimed to compare serum CK‐MM levels in patients with and without adenomyosis and to investigate whether CK‐MM level can be a non‐invasive marker for myometrial damage due to adenomyosis.
Materials and Methods
Our study was a prospective case‐control study in a tertiary center and consisted of 40 patients with a clinical/ultrasonographic diagnosis of adenomyosis and 40 patients without a clinical/ultrasonographic diagnosis of adenomyosis as the control group based on recently published morphological uterus sonographic assessment (MUSA) criteria. Individuals of similar age who signed a voluntary consent form were included in our study. Demographic, clinical, and laboratory findings of the patients in both groups were recorded. Blood serum samples were used for the determination of serum CK‐MM levels of the participants in our study. The samples were analyzed by using the human CK‐MM enzyme‐linked immunosorbent assay (ELISA) kit.
Results
In our study, the mean serum CK‐MM level was 16.2 ± 21.7 (ng/dL) in patients with adenomyosis and 2.6 ± 2.2 (ng/dL) in patients without adenomyosis. Serum CK‐MM level was statistically significantly higher in the patient group with adenomyosis than in the control group (p |
| doi_str_mv | 10.1002/ijgo.15824 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3086382454</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3086382454</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2544-cd692972bfd2274c77355359af4c94265fffa8b9d7d9eb48bc113cf3f5a123603</originalsourceid><addsrcrecordid>eNp9kM1O3DAQgK2qFWyBSx-g8hEhhfov6_iIUEupkLgA18hxxmBI7K0nWbSc-gh9xj5JTRc4VvLIh_n0afQR8omzY86Y-BLub9Mxrxuh3pEFb7SppNLmPVmUJau0MGKXfES8Z4xxzfkO2ZWGNZxrtiBPN3aYgSZPEfI80nFGNw82U5fBTiGGCHR1l7DMQ4gWgQ6whgFpiHRVAIgT0scw3VHbQ0zjJmFAasujMcU_v36HuLYY1kD7YG9jwik4Otr8AHmffPB2QDh4-ffI9bevV6ffq4vLs_PTk4vKiVqpyvVLI4wWne-F0MppLeta1sZ65YwSy9p7b5vO9Lo30Kmmc5xL56WvLRdyyeQeOdx6Vzn9nAGndgzoYBhshDRjK1mzlCVerQp6tEVdTogZfLvKoVy7aTlrn1u3z63bf60L_PnFO3cj9G_oa9wC8C3wGAbY_EfVnv84u9xK_wKNcY08</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3086382454</pqid></control><display><type>article</type><title>Value of serum muscular creatinine phosphokinase levels in patients with adenomyosis as a non‐invasive diagnostic marker</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Bulut Aydemir, Hilal Mürüvvet ; Kahyaoğlu, Serkan ; Halilzade, İnci ; Moraloğlu‐Tekin, Özlem</creator><creatorcontrib>Bulut Aydemir, Hilal Mürüvvet ; Kahyaoğlu, Serkan ; Halilzade, İnci ; Moraloğlu‐Tekin, Özlem</creatorcontrib><description>Objective
In the present study, we aimed to compare serum CK‐MM levels in patients with and without adenomyosis and to investigate whether CK‐MM level can be a non‐invasive marker for myometrial damage due to adenomyosis.
Materials and Methods
Our study was a prospective case‐control study in a tertiary center and consisted of 40 patients with a clinical/ultrasonographic diagnosis of adenomyosis and 40 patients without a clinical/ultrasonographic diagnosis of adenomyosis as the control group based on recently published morphological uterus sonographic assessment (MUSA) criteria. Individuals of similar age who signed a voluntary consent form were included in our study. Demographic, clinical, and laboratory findings of the patients in both groups were recorded. Blood serum samples were used for the determination of serum CK‐MM levels of the participants in our study. The samples were analyzed by using the human CK‐MM enzyme‐linked immunosorbent assay (ELISA) kit.
Results
In our study, the mean serum CK‐MM level was 16.2 ± 21.7 (ng/dL) in patients with adenomyosis and 2.6 ± 2.2 (ng/dL) in patients without adenomyosis. Serum CK‐MM level was statistically significantly higher in the patient group with adenomyosis than in the control group (p < 0.001). The CK‐MM threshold value of 3.43 ng/mL, with a sensitivity of 82.5% and specificity of 85%, has been found to be a valuable distinguishing level in patients with and without adenomyosis.
Conclusion
In this study, we demonstrated that serum CK‐MM can be used as a non‐invasive diagnostic method in patients with adenomyosis. As the number of studies around this subject in the literature is insufficient, larger studies are needed to use CK‐MM as a diagnostic marker in adenomyosis.
Synopsis
CK‐MM could be a predictive marker in the non‐invasive diagnosis of adenomyosis in the future.</description><identifier>ISSN: 0020-7292</identifier><identifier>ISSN: 1879-3479</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1002/ijgo.15824</identifier><identifier>PMID: 39081170</identifier><language>eng</language><publisher>United States</publisher><subject>abnormal uterine bleeding ; adenomyosis ; Adenomyosis - blood ; Adenomyosis - diagnosis ; Adult ; Biomarkers - blood ; Case-Control Studies ; CK‐MM ; creatinine phosphokinase ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; marker ; Middle Aged ; Myometrium - diagnostic imaging ; Myometrium - pathology ; non‐invasive ; Prospective Studies ; ROC Curve ; Sensitivity and Specificity ; Ultrasonography</subject><ispartof>International journal of gynecology and obstetrics, 2024-07, Vol.168 (1), p.314-319</ispartof><rights>2024 International Federation of Gynecology and Obstetrics.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2544-cd692972bfd2274c77355359af4c94265fffa8b9d7d9eb48bc113cf3f5a123603</cites><orcidid>0000-0001-8964-3552 ; 0000-0002-3078-8420 ; 0000-0003-0645-4786 ; 0000-0001-8167-3837</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijgo.15824$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijgo.15824$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39081170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bulut Aydemir, Hilal Mürüvvet</creatorcontrib><creatorcontrib>Kahyaoğlu, Serkan</creatorcontrib><creatorcontrib>Halilzade, İnci</creatorcontrib><creatorcontrib>Moraloğlu‐Tekin, Özlem</creatorcontrib><title>Value of serum muscular creatinine phosphokinase levels in patients with adenomyosis as a non‐invasive diagnostic marker</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Objective
In the present study, we aimed to compare serum CK‐MM levels in patients with and without adenomyosis and to investigate whether CK‐MM level can be a non‐invasive marker for myometrial damage due to adenomyosis.
Materials and Methods
Our study was a prospective case‐control study in a tertiary center and consisted of 40 patients with a clinical/ultrasonographic diagnosis of adenomyosis and 40 patients without a clinical/ultrasonographic diagnosis of adenomyosis as the control group based on recently published morphological uterus sonographic assessment (MUSA) criteria. Individuals of similar age who signed a voluntary consent form were included in our study. Demographic, clinical, and laboratory findings of the patients in both groups were recorded. Blood serum samples were used for the determination of serum CK‐MM levels of the participants in our study. The samples were analyzed by using the human CK‐MM enzyme‐linked immunosorbent assay (ELISA) kit.
Results
In our study, the mean serum CK‐MM level was 16.2 ± 21.7 (ng/dL) in patients with adenomyosis and 2.6 ± 2.2 (ng/dL) in patients without adenomyosis. Serum CK‐MM level was statistically significantly higher in the patient group with adenomyosis than in the control group (p < 0.001). The CK‐MM threshold value of 3.43 ng/mL, with a sensitivity of 82.5% and specificity of 85%, has been found to be a valuable distinguishing level in patients with and without adenomyosis.
Conclusion
In this study, we demonstrated that serum CK‐MM can be used as a non‐invasive diagnostic method in patients with adenomyosis. As the number of studies around this subject in the literature is insufficient, larger studies are needed to use CK‐MM as a diagnostic marker in adenomyosis.
Synopsis
CK‐MM could be a predictive marker in the non‐invasive diagnosis of adenomyosis in the future.</description><subject>abnormal uterine bleeding</subject><subject>adenomyosis</subject><subject>Adenomyosis - blood</subject><subject>Adenomyosis - diagnosis</subject><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>CK‐MM</subject><subject>creatinine phosphokinase</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>marker</subject><subject>Middle Aged</subject><subject>Myometrium - diagnostic imaging</subject><subject>Myometrium - pathology</subject><subject>non‐invasive</subject><subject>Prospective Studies</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonography</subject><issn>0020-7292</issn><issn>1879-3479</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1O3DAQgK2qFWyBSx-g8hEhhfov6_iIUEupkLgA18hxxmBI7K0nWbSc-gh9xj5JTRc4VvLIh_n0afQR8omzY86Y-BLub9Mxrxuh3pEFb7SppNLmPVmUJau0MGKXfES8Z4xxzfkO2ZWGNZxrtiBPN3aYgSZPEfI80nFGNw82U5fBTiGGCHR1l7DMQ4gWgQ6whgFpiHRVAIgT0scw3VHbQ0zjJmFAasujMcU_v36HuLYY1kD7YG9jwik4Otr8AHmffPB2QDh4-ffI9bevV6ffq4vLs_PTk4vKiVqpyvVLI4wWne-F0MppLeta1sZ65YwSy9p7b5vO9Lo30Kmmc5xL56WvLRdyyeQeOdx6Vzn9nAGndgzoYBhshDRjK1mzlCVerQp6tEVdTogZfLvKoVy7aTlrn1u3z63bf60L_PnFO3cj9G_oa9wC8C3wGAbY_EfVnv84u9xK_wKNcY08</recordid><startdate>20240731</startdate><enddate>20240731</enddate><creator>Bulut Aydemir, Hilal Mürüvvet</creator><creator>Kahyaoğlu, Serkan</creator><creator>Halilzade, İnci</creator><creator>Moraloğlu‐Tekin, Özlem</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8964-3552</orcidid><orcidid>https://orcid.org/0000-0002-3078-8420</orcidid><orcidid>https://orcid.org/0000-0003-0645-4786</orcidid><orcidid>https://orcid.org/0000-0001-8167-3837</orcidid></search><sort><creationdate>20240731</creationdate><title>Value of serum muscular creatinine phosphokinase levels in patients with adenomyosis as a non‐invasive diagnostic marker</title><author>Bulut Aydemir, Hilal Mürüvvet ; Kahyaoğlu, Serkan ; Halilzade, İnci ; Moraloğlu‐Tekin, Özlem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2544-cd692972bfd2274c77355359af4c94265fffa8b9d7d9eb48bc113cf3f5a123603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>abnormal uterine bleeding</topic><topic>adenomyosis</topic><topic>Adenomyosis - blood</topic><topic>Adenomyosis - diagnosis</topic><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>CK‐MM</topic><topic>creatinine phosphokinase</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>marker</topic><topic>Middle Aged</topic><topic>Myometrium - diagnostic imaging</topic><topic>Myometrium - pathology</topic><topic>non‐invasive</topic><topic>Prospective Studies</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bulut Aydemir, Hilal Mürüvvet</creatorcontrib><creatorcontrib>Kahyaoğlu, Serkan</creatorcontrib><creatorcontrib>Halilzade, İnci</creatorcontrib><creatorcontrib>Moraloğlu‐Tekin, Özlem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bulut Aydemir, Hilal Mürüvvet</au><au>Kahyaoğlu, Serkan</au><au>Halilzade, İnci</au><au>Moraloğlu‐Tekin, Özlem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of serum muscular creatinine phosphokinase levels in patients with adenomyosis as a non‐invasive diagnostic marker</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2024-07-31</date><risdate>2024</risdate><volume>168</volume><issue>1</issue><spage>314</spage><epage>319</epage><pages>314-319</pages><issn>0020-7292</issn><issn>1879-3479</issn><eissn>1879-3479</eissn><abstract>Objective
In the present study, we aimed to compare serum CK‐MM levels in patients with and without adenomyosis and to investigate whether CK‐MM level can be a non‐invasive marker for myometrial damage due to adenomyosis.
Materials and Methods
Our study was a prospective case‐control study in a tertiary center and consisted of 40 patients with a clinical/ultrasonographic diagnosis of adenomyosis and 40 patients without a clinical/ultrasonographic diagnosis of adenomyosis as the control group based on recently published morphological uterus sonographic assessment (MUSA) criteria. Individuals of similar age who signed a voluntary consent form were included in our study. Demographic, clinical, and laboratory findings of the patients in both groups were recorded. Blood serum samples were used for the determination of serum CK‐MM levels of the participants in our study. The samples were analyzed by using the human CK‐MM enzyme‐linked immunosorbent assay (ELISA) kit.
Results
In our study, the mean serum CK‐MM level was 16.2 ± 21.7 (ng/dL) in patients with adenomyosis and 2.6 ± 2.2 (ng/dL) in patients without adenomyosis. Serum CK‐MM level was statistically significantly higher in the patient group with adenomyosis than in the control group (p < 0.001). The CK‐MM threshold value of 3.43 ng/mL, with a sensitivity of 82.5% and specificity of 85%, has been found to be a valuable distinguishing level in patients with and without adenomyosis.
Conclusion
In this study, we demonstrated that serum CK‐MM can be used as a non‐invasive diagnostic method in patients with adenomyosis. As the number of studies around this subject in the literature is insufficient, larger studies are needed to use CK‐MM as a diagnostic marker in adenomyosis.
Synopsis
CK‐MM could be a predictive marker in the non‐invasive diagnosis of adenomyosis in the future.</abstract><cop>United States</cop><pmid>39081170</pmid><doi>10.1002/ijgo.15824</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8964-3552</orcidid><orcidid>https://orcid.org/0000-0002-3078-8420</orcidid><orcidid>https://orcid.org/0000-0003-0645-4786</orcidid><orcidid>https://orcid.org/0000-0001-8167-3837</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7292 |
| ispartof | International journal of gynecology and obstetrics, 2024-07, Vol.168 (1), p.314-319 |
| issn | 0020-7292 1879-3479 1879-3479 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3086382454 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | abnormal uterine bleeding adenomyosis Adenomyosis - blood Adenomyosis - diagnosis Adult Biomarkers - blood Case-Control Studies CK‐MM creatinine phosphokinase Enzyme-Linked Immunosorbent Assay Female Humans marker Middle Aged Myometrium - diagnostic imaging Myometrium - pathology non‐invasive Prospective Studies ROC Curve Sensitivity and Specificity Ultrasonography |
| title | Value of serum muscular creatinine phosphokinase levels in patients with adenomyosis as a non‐invasive diagnostic marker |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T20%3A49%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Value%20of%20serum%20muscular%20creatinine%20phosphokinase%20levels%20in%20patients%20with%20adenomyosis%20as%20a%20non%E2%80%90invasive%20diagnostic%20marker&rft.jtitle=International%20journal%20of%20gynecology%20and%20obstetrics&rft.au=Bulut%20Aydemir,%20Hilal%20M%C3%BCr%C3%BCvvet&rft.date=2024-07-31&rft.volume=168&rft.issue=1&rft.spage=314&rft.epage=319&rft.pages=314-319&rft.issn=0020-7292&rft.eissn=1879-3479&rft_id=info:doi/10.1002/ijgo.15824&rft_dat=%3Cproquest_cross%3E3086382454%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3086382454&rft_id=info:pmid/39081170&rfr_iscdi=true |