Laboratory profiling of patients with long COVID in the Brazilian Amazon region: A cross‐sectional study
The condition commonly referred to as long coronavirus disease (COVID) is characterized by the continuation of symptoms, sometimes accompanied by new symptoms that persist after the resolution of acute coronavirus disease 2019 (COVID‐19). This observational cross‐sectional study investigated 332 pat...
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| Veröffentlicht in: | Journal of medical virology 2024-08, Vol.96 (8), p.e29828-n/a |
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| creator | Galúcio, Vanessa Costa Alves Menezes, Daniel Carvalho Chaves, Elem Cristina Rodrigues Berg, Ana Virgínia Soares Lima, Patrícia Danielle Lima Costa Vasconcelos, Pedro Fernando Quaresma, Juarez Antônio Simões Falcão, Luiz Fábio Magno |
| description | The condition commonly referred to as long coronavirus disease (COVID) is characterized by the continuation of symptoms, sometimes accompanied by new symptoms that persist after the resolution of acute coronavirus disease 2019 (COVID‐19). This observational cross‐sectional study investigated 332 patients with long COVID in the Brazilian Amazon region. The study aimed to elucidate the systemic interactions associated with long COVID by compiling the findings related to hematological, coagulation, immunological, metabolic, hepatic, renal, and muscular profiles. Participants with long COVID were identified using rigorous criteria and underwent thorough laboratory examinations. The obtained data were subsequently analyzed, allowing for comparisons, associations, and correlations between findings within distinct groups in the study. Significant associations were observed between hospitalization during the acute phase and persistent laboratory abnormalities, suggesting a potential link between acute severity and long‐term effects. Notably, individuals with long COVID for over a year exhibited elevated levels of monocytes, prolonged prothrombin times, reduced prothrombin activity, high levels of lactate dehydrogenase, and an increased frequency of qualitative C‐reactive protein detection. This study provides valuable insights into the laboratory risk profile of patients with long COVID, particularly in the unique context of the Amazon region, where patients exhibit persistent symptoms lasting up to 1261 days. |
| doi_str_mv | 10.1002/jmv.29828 |
| format | Article |
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This observational cross‐sectional study investigated 332 patients with long COVID in the Brazilian Amazon region. The study aimed to elucidate the systemic interactions associated with long COVID by compiling the findings related to hematological, coagulation, immunological, metabolic, hepatic, renal, and muscular profiles. Participants with long COVID were identified using rigorous criteria and underwent thorough laboratory examinations. The obtained data were subsequently analyzed, allowing for comparisons, associations, and correlations between findings within distinct groups in the study. Significant associations were observed between hospitalization during the acute phase and persistent laboratory abnormalities, suggesting a potential link between acute severity and long‐term effects. Notably, individuals with long COVID for over a year exhibited elevated levels of monocytes, prolonged prothrombin times, reduced prothrombin activity, high levels of lactate dehydrogenase, and an increased frequency of qualitative C‐reactive protein detection. This study provides valuable insights into the laboratory risk profile of patients with long COVID, particularly in the unique context of the Amazon region, where patients exhibit persistent symptoms lasting up to 1261 days.</description><identifier>ISSN: 0146-6615</identifier><identifier>ISSN: 1096-9071</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.29828</identifier><identifier>PMID: 39081145</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Abnormalities ; Adult ; Aged ; Aged, 80 and over ; biomarkers ; Brazil - epidemiology ; C-Reactive Protein - analysis ; Coagulation ; Coronaviruses ; COVID-19 ; COVID-19 - blood ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; Cross-Sectional Studies ; Female ; hematological tests ; Hospitalization - statistics & numerical data ; Humans ; Immunology ; L-Lactate dehydrogenase ; Laboratories ; laboratory markers ; Lactate dehydrogenase ; Long COVID ; Male ; Middle Aged ; Monocytes ; Prothrombin ; Qualitative analysis ; SARS-CoV-2 ; Signs and symptoms ; Viral diseases</subject><ispartof>Journal of medical virology, 2024-08, Vol.96 (8), p.e29828-n/a</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2788-cc5fb72da8f55aac99d85c7c63b7be746aa018fc5915aaa40e2ed1f4f0413da83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.29828$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.29828$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39081145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galúcio, Vanessa Costa Alves</creatorcontrib><creatorcontrib>Menezes, Daniel Carvalho</creatorcontrib><creatorcontrib>Chaves, Elem Cristina Rodrigues</creatorcontrib><creatorcontrib>Berg, Ana Virgínia Soares</creatorcontrib><creatorcontrib>Lima, Patrícia Danielle Lima</creatorcontrib><creatorcontrib>Costa Vasconcelos, Pedro Fernando</creatorcontrib><creatorcontrib>Quaresma, Juarez Antônio Simões</creatorcontrib><creatorcontrib>Falcão, Luiz Fábio Magno</creatorcontrib><title>Laboratory profiling of patients with long COVID in the Brazilian Amazon region: A cross‐sectional study</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>The condition commonly referred to as long coronavirus disease (COVID) is characterized by the continuation of symptoms, sometimes accompanied by new symptoms that persist after the resolution of acute coronavirus disease 2019 (COVID‐19). This observational cross‐sectional study investigated 332 patients with long COVID in the Brazilian Amazon region. The study aimed to elucidate the systemic interactions associated with long COVID by compiling the findings related to hematological, coagulation, immunological, metabolic, hepatic, renal, and muscular profiles. Participants with long COVID were identified using rigorous criteria and underwent thorough laboratory examinations. The obtained data were subsequently analyzed, allowing for comparisons, associations, and correlations between findings within distinct groups in the study. Significant associations were observed between hospitalization during the acute phase and persistent laboratory abnormalities, suggesting a potential link between acute severity and long‐term effects. Notably, individuals with long COVID for over a year exhibited elevated levels of monocytes, prolonged prothrombin times, reduced prothrombin activity, high levels of lactate dehydrogenase, and an increased frequency of qualitative C‐reactive protein detection. This study provides valuable insights into the laboratory risk profile of patients with long COVID, particularly in the unique context of the Amazon region, where patients exhibit persistent symptoms lasting up to 1261 days.</description><subject>Abnormalities</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>biomarkers</subject><subject>Brazil - epidemiology</subject><subject>C-Reactive Protein - analysis</subject><subject>Coagulation</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - blood</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>hematological tests</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Immunology</subject><subject>L-Lactate dehydrogenase</subject><subject>Laboratories</subject><subject>laboratory markers</subject><subject>Lactate dehydrogenase</subject><subject>Long COVID</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Prothrombin</subject><subject>Qualitative analysis</subject><subject>SARS-CoV-2</subject><subject>Signs and symptoms</subject><subject>Viral diseases</subject><issn>0146-6615</issn><issn>1096-9071</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10btOwzAUBmALgWgpDLwAssQCQ4qdq81Wyq2oqAt0jRzHbl0lcbETqnbiEXhGngT3AgMSk6Xjz798zgHgFKMuRsi_mpXvXZ8Sn-yBNkY09ihK8D5oIxzGXhzjqAWOrJ0hhAj1_UPQCigiGIdRG8yGLNOG1dos4dxoqQpVTaCWcM5qJarawoWqp7DQrtofjQe3UFWwngp4Y9jKYVbBXslWuoJGTJSurmEPcqOt_fr4tILXrsQKaOsmXx6DA8kKK052Zwe83t-99B-94ehh0O8NPe4nhHicRzJL_JwRGUWMcUpzEvGEx0GWZCIJY8YQJpJHFLtrFiLhixzLUKIQB-5V0AEX21zXz1sjbJ2WynJRFKwSurFpgEgcEOzm4uj5HzrTjXE_XiuaxJiigDp1uVWbxoyQ6dyokpllilG6XkDqFpBuFuDs2S6xyUqR_8qfiTtwtQULVYjl_0np0_N4G_kN6ViRJA</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Galúcio, Vanessa Costa Alves</creator><creator>Menezes, Daniel Carvalho</creator><creator>Chaves, Elem Cristina Rodrigues</creator><creator>Berg, Ana Virgínia Soares</creator><creator>Lima, Patrícia Danielle Lima</creator><creator>Costa Vasconcelos, Pedro Fernando</creator><creator>Quaresma, Juarez Antônio Simões</creator><creator>Falcão, Luiz Fábio Magno</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>202408</creationdate><title>Laboratory profiling of patients with long COVID in the Brazilian Amazon region: A cross‐sectional study</title><author>Galúcio, Vanessa Costa Alves ; 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This observational cross‐sectional study investigated 332 patients with long COVID in the Brazilian Amazon region. The study aimed to elucidate the systemic interactions associated with long COVID by compiling the findings related to hematological, coagulation, immunological, metabolic, hepatic, renal, and muscular profiles. Participants with long COVID were identified using rigorous criteria and underwent thorough laboratory examinations. The obtained data were subsequently analyzed, allowing for comparisons, associations, and correlations between findings within distinct groups in the study. Significant associations were observed between hospitalization during the acute phase and persistent laboratory abnormalities, suggesting a potential link between acute severity and long‐term effects. Notably, individuals with long COVID for over a year exhibited elevated levels of monocytes, prolonged prothrombin times, reduced prothrombin activity, high levels of lactate dehydrogenase, and an increased frequency of qualitative C‐reactive protein detection. This study provides valuable insights into the laboratory risk profile of patients with long COVID, particularly in the unique context of the Amazon region, where patients exhibit persistent symptoms lasting up to 1261 days.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39081145</pmid><doi>10.1002/jmv.29828</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of medical virology, 2024-08, Vol.96 (8), p.e29828-n/a |
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| subjects | Abnormalities Adult Aged Aged, 80 and over biomarkers Brazil - epidemiology C-Reactive Protein - analysis Coagulation Coronaviruses COVID-19 COVID-19 - blood COVID-19 - diagnosis COVID-19 - epidemiology Cross-Sectional Studies Female hematological tests Hospitalization - statistics & numerical data Humans Immunology L-Lactate dehydrogenase Laboratories laboratory markers Lactate dehydrogenase Long COVID Male Middle Aged Monocytes Prothrombin Qualitative analysis SARS-CoV-2 Signs and symptoms Viral diseases |
| title | Laboratory profiling of patients with long COVID in the Brazilian Amazon region: A cross‐sectional study |
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