Preparation and chromatographic evaluation of hydrophilic polymer brushes grafted-silica with post modification of silicon/carbon dots as a green liquid chromatography stationary phase

Polar stationary phases were prepared by grafting hydrophilic acrylamide (Am) polymer brushes with post modification of carbon dots (CDs) and silicon dots (SiDs) onto SiO 2 particles. The prepared stationary phases, SiO 2 -PAm-CDs, SiO 2 -PAm-CDs/SiDs, and SiO 2 -PAm-SiDs, were packed as chromatogra...

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Veröffentlicht in:Mikrochimica acta (1966) 2024-08, Vol.191 (8), p.495, Article 495
Hauptverfasser: Bo, Chunmiao, Tang, Xiaofan, Li, Yan, Li, Yinhai, Zhao, Weilong, Guo, Shengwei
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container_start_page 495
container_title Mikrochimica acta (1966)
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creator Bo, Chunmiao
Tang, Xiaofan
Li, Yan
Li, Yinhai
Zhao, Weilong
Guo, Shengwei
description Polar stationary phases were prepared by grafting hydrophilic acrylamide (Am) polymer brushes with post modification of carbon dots (CDs) and silicon dots (SiDs) onto SiO 2 particles. The prepared stationary phases, SiO 2 -PAm-CDs, SiO 2 -PAm-CDs/SiDs, and SiO 2 -PAm-SiDs, were packed as chromatographic columns, respectively. Using nucleic bases, organic acids, and β-agonists as target substances to investigate the influence of chromatographic conditions on retention and separation, the packed columns showed the partitioning and adsorption of mixed retention behavior in hydrophilic interaction liquid chromatography mode and successfully separated the polar compounds. Most importantly, under per aqueous liquid chromatography mode (using 100% water as mobile phase), those columns still had good separation ability toward nucleic bases, β-agonist, and organic acids. Because AM is a temperature-sensitive monomer, the resulting van’t Hoff curves exhibited a nonlinear relationship, having temperature-responsive chromatographic characteristic under pure water separation. Hence, building on temperature-sensitive characteristics and pure water of separation conditions, the separation selectivity toward hydrophilic compounds greatly improved. Compared with the commercial hydrophilic columns, the efficiency of our developed column had the superior ability in separation and detection of betaine in Goji berry with the enhanced resolution achieved in the proposed green separation method (just using pure water as mobile phase). Graphical Abstract
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The prepared stationary phases, SiO 2 -PAm-CDs, SiO 2 -PAm-CDs/SiDs, and SiO 2 -PAm-SiDs, were packed as chromatographic columns, respectively. Using nucleic bases, organic acids, and β-agonists as target substances to investigate the influence of chromatographic conditions on retention and separation, the packed columns showed the partitioning and adsorption of mixed retention behavior in hydrophilic interaction liquid chromatography mode and successfully separated the polar compounds. Most importantly, under per aqueous liquid chromatography mode (using 100% water as mobile phase), those columns still had good separation ability toward nucleic bases, β-agonist, and organic acids. Because AM is a temperature-sensitive monomer, the resulting van’t Hoff curves exhibited a nonlinear relationship, having temperature-responsive chromatographic characteristic under pure water separation. Hence, building on temperature-sensitive characteristics and pure water of separation conditions, the separation selectivity toward hydrophilic compounds greatly improved. Compared with the commercial hydrophilic columns, the efficiency of our developed column had the superior ability in separation and detection of betaine in Goji berry with the enhanced resolution achieved in the proposed green separation method (just using pure water as mobile phase). 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The prepared stationary phases, SiO 2 -PAm-CDs, SiO 2 -PAm-CDs/SiDs, and SiO 2 -PAm-SiDs, were packed as chromatographic columns, respectively. Using nucleic bases, organic acids, and β-agonists as target substances to investigate the influence of chromatographic conditions on retention and separation, the packed columns showed the partitioning and adsorption of mixed retention behavior in hydrophilic interaction liquid chromatography mode and successfully separated the polar compounds. Most importantly, under per aqueous liquid chromatography mode (using 100% water as mobile phase), those columns still had good separation ability toward nucleic bases, β-agonist, and organic acids. Because AM is a temperature-sensitive monomer, the resulting van’t Hoff curves exhibited a nonlinear relationship, having temperature-responsive chromatographic characteristic under pure water separation. Hence, building on temperature-sensitive characteristics and pure water of separation conditions, the separation selectivity toward hydrophilic compounds greatly improved. Compared with the commercial hydrophilic columns, the efficiency of our developed column had the superior ability in separation and detection of betaine in Goji berry with the enhanced resolution achieved in the proposed green separation method (just using pure water as mobile phase). 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Hence, building on temperature-sensitive characteristics and pure water of separation conditions, the separation selectivity toward hydrophilic compounds greatly improved. Compared with the commercial hydrophilic columns, the efficiency of our developed column had the superior ability in separation and detection of betaine in Goji berry with the enhanced resolution achieved in the proposed green separation method (just using pure water as mobile phase). Graphical Abstract</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>39080110</pmid><doi>10.1007/s00604-024-06575-y</doi></addata></record>
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subjects Acrylamide
Analytical Chemistry
Brushes
Carbon dots
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chromatography
Hydrophilicity
Liquid chromatography
Microengineering
Nanochemistry
Nanotechnology
Organic acids
Packed columns
Polymers
Separation
Silicon dioxide
title Preparation and chromatographic evaluation of hydrophilic polymer brushes grafted-silica with post modification of silicon/carbon dots as a green liquid chromatography stationary phase
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