Impact of bile leak on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection
Purpose The impact of postoperative bile leak on the prognosis of patients with hepatocellular carcinoma who underwent liver resection is controversial. This study aimed to investigate the prognostic impact of bile leak for patients with hepatocellular carcinoma who underwent liver resection. Method...
Gespeichert in:
| Veröffentlicht in: | Langenbeck's archives of surgery 2024-07, Vol.409 (1), p.233, Article 233 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 233 |
| container_title | Langenbeck's archives of surgery |
| container_volume | 409 |
| creator | Gon, Hidetoshi Komatsu, Shohei Soyama, Hirotoshi Tanaka, Motofumi Fukushima, Kenji Urade, Takeshi So, Shinichi Yoshida, Toshihiko Arai, Keisuke Ishida, Jun Nanno, Yoshihide Tsugawa, Daisuke Yanagimoto, Hiroaki Toyama, Hirochika Kido, Masahiro Fukumoto, Takumi |
| description | Purpose
The impact of postoperative bile leak on the prognosis of patients with hepatocellular carcinoma who underwent liver resection is controversial. This study aimed to investigate the prognostic impact of bile leak for patients with hepatocellular carcinoma who underwent liver resection.
Methods
Patients with hepatocellular carcinoma who underwent liver resection between 2009 and 2019 at Kobe University Hospital and Hyogo Cancer Center were included. After propensity score matching between the bile leak and no bile leak groups, differences in 5-year recurrence-free and overall survival rates were evaluated using the Kaplan–Meier method.
Results
A total of 781 patients, including 43 with postoperative bile leak, were analyzed. In the matched cohort, 40 patients were included in each group. The 5-year recurrence-free survival rates after liver resection were 35% and 32% for the bile leak and no bile leak groups, respectively (
P
= 0.857). The 5-year overall survival rates were 44% and 54% for the bile leak and no bile leak groups, respectively (
P
= 0.216).
Conclusion
Overall, bile leak may not have a profound negative impact on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection. |
| doi_str_mv | 10.1007/s00423-024-03430-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3086066887</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3086066887</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-6d69a9ce6ae1816053b972a9942358cdfd8d0cc4d4cba656400b7e60e4d3b1f43</originalsourceid><addsrcrecordid>eNp9kD9v3DAMxYWiQf5_gQyBxi5OKUuWrbE4tE2AAF2aWZBl-qyrLd1JdoJ8--pylyJTJ5Lg4wPfj5AbBncMoP6aAETJCyhFAVxwKNQncs4Er4pSVOzzh_6MXKS0AQBZK3FKzriCuhGCnZPdw7Q1dqahp60bkY5o_tDg6Twg3caw9iG5tN9uzezQz4m-uHmgA-Y5WBzHZTSRWhOt82Ey9GUIdDDPSBffYVwHny3dM0YaMaGdXfBX5KQ3Y8LrY70kTz--_17dF4-_fj6svj0WtiybuZCdVEZZlAZZwyRUvFV1aZTKkavGdn3XdGCt6IRtjaykAGhrlICi4y3rBb8kXw6-OcZuwTTryaX9x8ZjWJLm0EiQsmnqLC0PUhtDShF7vY1uMvFVM9B71PqAWmfU-g21Vvno9ui_tBN2_07e2WYBPwhSXvk1Rr0JS_Q58_9s_wLDwYtI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3086066887</pqid></control><display><type>article</type><title>Impact of bile leak on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Gon, Hidetoshi ; Komatsu, Shohei ; Soyama, Hirotoshi ; Tanaka, Motofumi ; Fukushima, Kenji ; Urade, Takeshi ; So, Shinichi ; Yoshida, Toshihiko ; Arai, Keisuke ; Ishida, Jun ; Nanno, Yoshihide ; Tsugawa, Daisuke ; Yanagimoto, Hiroaki ; Toyama, Hirochika ; Kido, Masahiro ; Fukumoto, Takumi</creator><creatorcontrib>Gon, Hidetoshi ; Komatsu, Shohei ; Soyama, Hirotoshi ; Tanaka, Motofumi ; Fukushima, Kenji ; Urade, Takeshi ; So, Shinichi ; Yoshida, Toshihiko ; Arai, Keisuke ; Ishida, Jun ; Nanno, Yoshihide ; Tsugawa, Daisuke ; Yanagimoto, Hiroaki ; Toyama, Hirochika ; Kido, Masahiro ; Fukumoto, Takumi</creatorcontrib><description>Purpose
The impact of postoperative bile leak on the prognosis of patients with hepatocellular carcinoma who underwent liver resection is controversial. This study aimed to investigate the prognostic impact of bile leak for patients with hepatocellular carcinoma who underwent liver resection.
Methods
Patients with hepatocellular carcinoma who underwent liver resection between 2009 and 2019 at Kobe University Hospital and Hyogo Cancer Center were included. After propensity score matching between the bile leak and no bile leak groups, differences in 5-year recurrence-free and overall survival rates were evaluated using the Kaplan–Meier method.
Results
A total of 781 patients, including 43 with postoperative bile leak, were analyzed. In the matched cohort, 40 patients were included in each group. The 5-year recurrence-free survival rates after liver resection were 35% and 32% for the bile leak and no bile leak groups, respectively (
P
= 0.857). The 5-year overall survival rates were 44% and 54% for the bile leak and no bile leak groups, respectively (
P
= 0.216).
Conclusion
Overall, bile leak may not have a profound negative impact on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection.</description><identifier>ISSN: 1435-2451</identifier><identifier>EISSN: 1435-2451</identifier><identifier>DOI: 10.1007/s00423-024-03430-9</identifier><identifier>PMID: 39078441</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdominal Surgery ; Aged ; Anastomotic Leak - etiology ; Anastomotic Leak - mortality ; Bile ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Cardiac Surgery ; Female ; General Surgery ; Hepatectomy ; Humans ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Postoperative Complications - etiology ; Postoperative Complications - mortality ; Prognosis ; Propensity Score ; Retrospective Studies ; Survival Rate ; Thoracic Surgery ; Traumatic Surgery ; Vascular Surgery</subject><ispartof>Langenbeck's archives of surgery, 2024-07, Vol.409 (1), p.233, Article 233</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-6d69a9ce6ae1816053b972a9942358cdfd8d0cc4d4cba656400b7e60e4d3b1f43</cites><orcidid>0000-0002-4338-6084</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00423-024-03430-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00423-024-03430-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39078441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gon, Hidetoshi</creatorcontrib><creatorcontrib>Komatsu, Shohei</creatorcontrib><creatorcontrib>Soyama, Hirotoshi</creatorcontrib><creatorcontrib>Tanaka, Motofumi</creatorcontrib><creatorcontrib>Fukushima, Kenji</creatorcontrib><creatorcontrib>Urade, Takeshi</creatorcontrib><creatorcontrib>So, Shinichi</creatorcontrib><creatorcontrib>Yoshida, Toshihiko</creatorcontrib><creatorcontrib>Arai, Keisuke</creatorcontrib><creatorcontrib>Ishida, Jun</creatorcontrib><creatorcontrib>Nanno, Yoshihide</creatorcontrib><creatorcontrib>Tsugawa, Daisuke</creatorcontrib><creatorcontrib>Yanagimoto, Hiroaki</creatorcontrib><creatorcontrib>Toyama, Hirochika</creatorcontrib><creatorcontrib>Kido, Masahiro</creatorcontrib><creatorcontrib>Fukumoto, Takumi</creatorcontrib><title>Impact of bile leak on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection</title><title>Langenbeck's archives of surgery</title><addtitle>Langenbecks Arch Surg</addtitle><addtitle>Langenbecks Arch Surg</addtitle><description>Purpose
The impact of postoperative bile leak on the prognosis of patients with hepatocellular carcinoma who underwent liver resection is controversial. This study aimed to investigate the prognostic impact of bile leak for patients with hepatocellular carcinoma who underwent liver resection.
Methods
Patients with hepatocellular carcinoma who underwent liver resection between 2009 and 2019 at Kobe University Hospital and Hyogo Cancer Center were included. After propensity score matching between the bile leak and no bile leak groups, differences in 5-year recurrence-free and overall survival rates were evaluated using the Kaplan–Meier method.
Results
A total of 781 patients, including 43 with postoperative bile leak, were analyzed. In the matched cohort, 40 patients were included in each group. The 5-year recurrence-free survival rates after liver resection were 35% and 32% for the bile leak and no bile leak groups, respectively (
P
= 0.857). The 5-year overall survival rates were 44% and 54% for the bile leak and no bile leak groups, respectively (
P
= 0.216).
Conclusion
Overall, bile leak may not have a profound negative impact on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection.</description><subject>Abdominal Surgery</subject><subject>Aged</subject><subject>Anastomotic Leak - etiology</subject><subject>Anastomotic Leak - mortality</subject><subject>Bile</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Cardiac Surgery</subject><subject>Female</subject><subject>General Surgery</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - mortality</subject><subject>Prognosis</subject><subject>Propensity Score</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Thoracic Surgery</subject><subject>Traumatic Surgery</subject><subject>Vascular Surgery</subject><issn>1435-2451</issn><issn>1435-2451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD9v3DAMxYWiQf5_gQyBxi5OKUuWrbE4tE2AAF2aWZBl-qyrLd1JdoJ8--pylyJTJ5Lg4wPfj5AbBncMoP6aAETJCyhFAVxwKNQncs4Er4pSVOzzh_6MXKS0AQBZK3FKzriCuhGCnZPdw7Q1dqahp60bkY5o_tDg6Twg3caw9iG5tN9uzezQz4m-uHmgA-Y5WBzHZTSRWhOt82Ey9GUIdDDPSBffYVwHny3dM0YaMaGdXfBX5KQ3Y8LrY70kTz--_17dF4-_fj6svj0WtiybuZCdVEZZlAZZwyRUvFV1aZTKkavGdn3XdGCt6IRtjaykAGhrlICi4y3rBb8kXw6-OcZuwTTryaX9x8ZjWJLm0EiQsmnqLC0PUhtDShF7vY1uMvFVM9B71PqAWmfU-g21Vvno9ui_tBN2_07e2WYBPwhSXvk1Rr0JS_Q58_9s_wLDwYtI</recordid><startdate>20240730</startdate><enddate>20240730</enddate><creator>Gon, Hidetoshi</creator><creator>Komatsu, Shohei</creator><creator>Soyama, Hirotoshi</creator><creator>Tanaka, Motofumi</creator><creator>Fukushima, Kenji</creator><creator>Urade, Takeshi</creator><creator>So, Shinichi</creator><creator>Yoshida, Toshihiko</creator><creator>Arai, Keisuke</creator><creator>Ishida, Jun</creator><creator>Nanno, Yoshihide</creator><creator>Tsugawa, Daisuke</creator><creator>Yanagimoto, Hiroaki</creator><creator>Toyama, Hirochika</creator><creator>Kido, Masahiro</creator><creator>Fukumoto, Takumi</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4338-6084</orcidid></search><sort><creationdate>20240730</creationdate><title>Impact of bile leak on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection</title><author>Gon, Hidetoshi ; Komatsu, Shohei ; Soyama, Hirotoshi ; Tanaka, Motofumi ; Fukushima, Kenji ; Urade, Takeshi ; So, Shinichi ; Yoshida, Toshihiko ; Arai, Keisuke ; Ishida, Jun ; Nanno, Yoshihide ; Tsugawa, Daisuke ; Yanagimoto, Hiroaki ; Toyama, Hirochika ; Kido, Masahiro ; Fukumoto, Takumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-6d69a9ce6ae1816053b972a9942358cdfd8d0cc4d4cba656400b7e60e4d3b1f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdominal Surgery</topic><topic>Aged</topic><topic>Anastomotic Leak - etiology</topic><topic>Anastomotic Leak - mortality</topic><topic>Bile</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Cardiac Surgery</topic><topic>Female</topic><topic>General Surgery</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - mortality</topic><topic>Prognosis</topic><topic>Propensity Score</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Thoracic Surgery</topic><topic>Traumatic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gon, Hidetoshi</creatorcontrib><creatorcontrib>Komatsu, Shohei</creatorcontrib><creatorcontrib>Soyama, Hirotoshi</creatorcontrib><creatorcontrib>Tanaka, Motofumi</creatorcontrib><creatorcontrib>Fukushima, Kenji</creatorcontrib><creatorcontrib>Urade, Takeshi</creatorcontrib><creatorcontrib>So, Shinichi</creatorcontrib><creatorcontrib>Yoshida, Toshihiko</creatorcontrib><creatorcontrib>Arai, Keisuke</creatorcontrib><creatorcontrib>Ishida, Jun</creatorcontrib><creatorcontrib>Nanno, Yoshihide</creatorcontrib><creatorcontrib>Tsugawa, Daisuke</creatorcontrib><creatorcontrib>Yanagimoto, Hiroaki</creatorcontrib><creatorcontrib>Toyama, Hirochika</creatorcontrib><creatorcontrib>Kido, Masahiro</creatorcontrib><creatorcontrib>Fukumoto, Takumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langenbeck's archives of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gon, Hidetoshi</au><au>Komatsu, Shohei</au><au>Soyama, Hirotoshi</au><au>Tanaka, Motofumi</au><au>Fukushima, Kenji</au><au>Urade, Takeshi</au><au>So, Shinichi</au><au>Yoshida, Toshihiko</au><au>Arai, Keisuke</au><au>Ishida, Jun</au><au>Nanno, Yoshihide</au><au>Tsugawa, Daisuke</au><au>Yanagimoto, Hiroaki</au><au>Toyama, Hirochika</au><au>Kido, Masahiro</au><au>Fukumoto, Takumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of bile leak on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection</atitle><jtitle>Langenbeck's archives of surgery</jtitle><stitle>Langenbecks Arch Surg</stitle><addtitle>Langenbecks Arch Surg</addtitle><date>2024-07-30</date><risdate>2024</risdate><volume>409</volume><issue>1</issue><spage>233</spage><pages>233-</pages><artnum>233</artnum><issn>1435-2451</issn><eissn>1435-2451</eissn><abstract>Purpose
The impact of postoperative bile leak on the prognosis of patients with hepatocellular carcinoma who underwent liver resection is controversial. This study aimed to investigate the prognostic impact of bile leak for patients with hepatocellular carcinoma who underwent liver resection.
Methods
Patients with hepatocellular carcinoma who underwent liver resection between 2009 and 2019 at Kobe University Hospital and Hyogo Cancer Center were included. After propensity score matching between the bile leak and no bile leak groups, differences in 5-year recurrence-free and overall survival rates were evaluated using the Kaplan–Meier method.
Results
A total of 781 patients, including 43 with postoperative bile leak, were analyzed. In the matched cohort, 40 patients were included in each group. The 5-year recurrence-free survival rates after liver resection were 35% and 32% for the bile leak and no bile leak groups, respectively (
P
= 0.857). The 5-year overall survival rates were 44% and 54% for the bile leak and no bile leak groups, respectively (
P
= 0.216).
Conclusion
Overall, bile leak may not have a profound negative impact on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39078441</pmid><doi>10.1007/s00423-024-03430-9</doi><orcidid>https://orcid.org/0000-0002-4338-6084</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1435-2451 |
| ispartof | Langenbeck's archives of surgery, 2024-07, Vol.409 (1), p.233, Article 233 |
| issn | 1435-2451 1435-2451 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3086066887 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Abdominal Surgery Aged Anastomotic Leak - etiology Anastomotic Leak - mortality Bile Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Cardiac Surgery Female General Surgery Hepatectomy Humans Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Postoperative Complications - etiology Postoperative Complications - mortality Prognosis Propensity Score Retrospective Studies Survival Rate Thoracic Surgery Traumatic Surgery Vascular Surgery |
| title | Impact of bile leak on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T16%3A27%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20bile%20leak%20on%20the%20prognosis%20of%20patients%20with%20hepatocellular%20carcinoma%20who%20have%20undergone%20liver%20resection&rft.jtitle=Langenbeck's%20archives%20of%20surgery&rft.au=Gon,%20Hidetoshi&rft.date=2024-07-30&rft.volume=409&rft.issue=1&rft.spage=233&rft.pages=233-&rft.artnum=233&rft.issn=1435-2451&rft.eissn=1435-2451&rft_id=info:doi/10.1007/s00423-024-03430-9&rft_dat=%3Cproquest_cross%3E3086066887%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3086066887&rft_id=info:pmid/39078441&rfr_iscdi=true |