High b-Value and Ultra-High b-Value Diffusion Weighted MRI in Stroke
To explore the application value of high-b-value and ultra-high b-value DWI in noninvasive evaluation of ischemic infarctions. Prospective. Sixty-four patients with clinically diagnosed ischemic lesions based on symptoms and DWI. 3.0 T/T2-weighted fast spin-echo, fluid-attenuated inversion recovery,...
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| creator | Jiang, Rifeng Wang, ZhenXiong Liu, Jun Li, Ting Lv, YanChun Xie, Chuanmiao Su, Changliang |
| description | To explore the application value of high-b-value and ultra-high b-value DWI in noninvasive evaluation of ischemic infarctions.
Prospective.
Sixty-four patients with clinically diagnosed ischemic lesions based on symptoms and DWI.
3.0 T/T2-weighted fast spin-echo, fluid-attenuated inversion recovery, pre-contrast T1-weighted magnetization prepared rapid gradient echo sequence, multi-b-value trace DWI and q-space sampling sequences.
Lesions were segmented on standard b-value DWI (SB-DWI, 1000 s/mm
), high b-value DWI (HB-DWI, 4000 s/mm
) and ultra-high b-value DWI (UB-DWI, 10,000 s/mm
), and cumulative segmented areas were the final abnormality volumes. Normal white matter (WM) areas were obtained after binarization of segmented brain. In 47 patients, fractional anisotropy (FA) and apparent diffusion coefficients (ADCs) at b values of 1000, 4000, and 10,000 s/mm
were extracted from symmetrical WM masks and lesion masks of contralateral WM (CWM) and lesion-side WM (LWM).
Wilcoxon matched-pairs signed-rank test and Pearson correlation analysis. Two-tailed P-values |
| doi_str_mv | 10.1002/jmri.29547 |
| format | Article |
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Prospective.
Sixty-four patients with clinically diagnosed ischemic lesions based on symptoms and DWI.
3.0 T/T2-weighted fast spin-echo, fluid-attenuated inversion recovery, pre-contrast T1-weighted magnetization prepared rapid gradient echo sequence, multi-b-value trace DWI and q-space sampling sequences.
Lesions were segmented on standard b-value DWI (SB-DWI, 1000 s/mm
), high b-value DWI (HB-DWI, 4000 s/mm
) and ultra-high b-value DWI (UB-DWI, 10,000 s/mm
), and cumulative segmented areas were the final abnormality volumes. Normal white matter (WM) areas were obtained after binarization of segmented brain. In 47 patients, fractional anisotropy (FA) and apparent diffusion coefficients (ADCs) at b values of 1000, 4000, and 10,000 s/mm
were extracted from symmetrical WM masks and lesion masks of contralateral WM (CWM) and lesion-side WM (LWM).
Wilcoxon matched-pairs signed-rank test and Pearson correlation analysis. Two-tailed P-values <0.05 were considered statistically significant.
Various signals of HB-/UB-DWI (hypo-, iso- or hyper-intensity) were observed in strokes compared with SB-DWI, and some areas with iso-intensity of SB-DWI manifested with hyper-intensity on HB-/UB-DWI. Abnormality volumes from SB-DWI were significantly smaller than those from HB-DWI and UB-DWI (10.32 ± 16.45 cm
, vs. 12.25 ± 19.71 cm
and 11.83 ± 19.41 cm
), while no significant difference exist in volume between HB-DWI and UB-DWI (P = 0.32). In CWM, FA significantly correlated with ADC
and ADC
(maximum r = -0.51 and -0.64), but did not significantly correlate with ADC
(maximum r = -0.20, P = 0.17). ADC
or ADC
of LWM not significant correlated with FA of CWM (maximum r = -0.28, P = 0.06), while ADC
of LWM significantly correlated with FA of CWM (maximum r = -0.46).
HB- and UB-DWI have potential to be supplementary tools for the noninvasive evaluation of stroke lesions in clinics.
2 TECHNICAL EFFICACY: Stage 2.</description><identifier>ISSN: 1053-1807</identifier><identifier>ISSN: 1522-2586</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.29547</identifier><identifier>PMID: 39074845</identifier><language>eng</language><publisher>United States</publisher><ispartof>Journal of magnetic resonance imaging, 2024-07</ispartof><rights>2024 International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c176t-b2537c32b480db83128f4901a6abbd2ec95b8a5215e71fb6dae6f12051d0c3d33</cites><orcidid>0000-0001-6959-0027 ; 0000-0002-4418-5823 ; 0000-0003-0064-4693 ; 0000-0001-8533-623X ; 0009-0001-6083-4459</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39074845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Rifeng</creatorcontrib><creatorcontrib>Wang, ZhenXiong</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Li, Ting</creatorcontrib><creatorcontrib>Lv, YanChun</creatorcontrib><creatorcontrib>Xie, Chuanmiao</creatorcontrib><creatorcontrib>Su, Changliang</creatorcontrib><title>High b-Value and Ultra-High b-Value Diffusion Weighted MRI in Stroke</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>To explore the application value of high-b-value and ultra-high b-value DWI in noninvasive evaluation of ischemic infarctions.
Prospective.
Sixty-four patients with clinically diagnosed ischemic lesions based on symptoms and DWI.
3.0 T/T2-weighted fast spin-echo, fluid-attenuated inversion recovery, pre-contrast T1-weighted magnetization prepared rapid gradient echo sequence, multi-b-value trace DWI and q-space sampling sequences.
Lesions were segmented on standard b-value DWI (SB-DWI, 1000 s/mm
), high b-value DWI (HB-DWI, 4000 s/mm
) and ultra-high b-value DWI (UB-DWI, 10,000 s/mm
), and cumulative segmented areas were the final abnormality volumes. Normal white matter (WM) areas were obtained after binarization of segmented brain. In 47 patients, fractional anisotropy (FA) and apparent diffusion coefficients (ADCs) at b values of 1000, 4000, and 10,000 s/mm
were extracted from symmetrical WM masks and lesion masks of contralateral WM (CWM) and lesion-side WM (LWM).
Wilcoxon matched-pairs signed-rank test and Pearson correlation analysis. Two-tailed P-values <0.05 were considered statistically significant.
Various signals of HB-/UB-DWI (hypo-, iso- or hyper-intensity) were observed in strokes compared with SB-DWI, and some areas with iso-intensity of SB-DWI manifested with hyper-intensity on HB-/UB-DWI. Abnormality volumes from SB-DWI were significantly smaller than those from HB-DWI and UB-DWI (10.32 ± 16.45 cm
, vs. 12.25 ± 19.71 cm
and 11.83 ± 19.41 cm
), while no significant difference exist in volume between HB-DWI and UB-DWI (P = 0.32). In CWM, FA significantly correlated with ADC
and ADC
(maximum r = -0.51 and -0.64), but did not significantly correlate with ADC
(maximum r = -0.20, P = 0.17). ADC
or ADC
of LWM not significant correlated with FA of CWM (maximum r = -0.28, P = 0.06), while ADC
of LWM significantly correlated with FA of CWM (maximum r = -0.46).
HB- and UB-DWI have potential to be supplementary tools for the noninvasive evaluation of stroke lesions in clinics.
2 TECHNICAL EFFICACY: Stage 2.</description><issn>1053-1807</issn><issn>1522-2586</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpVkE9LwzAchoMobk4vfgDpUYTMX5KmTY-yqRtMBHV6DEmTamb_bEl78NvbuSl4el9eHt7Dg9A5gTEBoNeryrsxzXicHqAh4ZRiykVy2HfgDBMB6QCdhLACgCyL-TEasAzSWMR8iKYz9_4Rafyqys5GqjbRsmy9wv_mqSuKLrimjt5sv7fWRA9P88jV0XPrm097io4KVQZ7ts8RWt7dvkxmePF4P5_cLHBO0qTFmnKW5ozqWIDRghEqijgDohKltaE2z7gWilPCbUoKnRhlk4JQ4MRAzgxjI3S5-137ZtPZ0MrKhdyWpapt0wXJQCSQUIC4R692aO6bELwt5Nq7SvkvSUBurcmtNfljrYcv9r-drqz5Q381sW971GYZ</recordid><startdate>20240729</startdate><enddate>20240729</enddate><creator>Jiang, Rifeng</creator><creator>Wang, ZhenXiong</creator><creator>Liu, Jun</creator><creator>Li, Ting</creator><creator>Lv, YanChun</creator><creator>Xie, Chuanmiao</creator><creator>Su, Changliang</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6959-0027</orcidid><orcidid>https://orcid.org/0000-0002-4418-5823</orcidid><orcidid>https://orcid.org/0000-0003-0064-4693</orcidid><orcidid>https://orcid.org/0000-0001-8533-623X</orcidid><orcidid>https://orcid.org/0009-0001-6083-4459</orcidid></search><sort><creationdate>20240729</creationdate><title>High b-Value and Ultra-High b-Value Diffusion Weighted MRI in Stroke</title><author>Jiang, Rifeng ; Wang, ZhenXiong ; Liu, Jun ; Li, Ting ; Lv, YanChun ; Xie, Chuanmiao ; Su, Changliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c176t-b2537c32b480db83128f4901a6abbd2ec95b8a5215e71fb6dae6f12051d0c3d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Rifeng</creatorcontrib><creatorcontrib>Wang, ZhenXiong</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Li, Ting</creatorcontrib><creatorcontrib>Lv, YanChun</creatorcontrib><creatorcontrib>Xie, Chuanmiao</creatorcontrib><creatorcontrib>Su, Changliang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Rifeng</au><au>Wang, ZhenXiong</au><au>Liu, Jun</au><au>Li, Ting</au><au>Lv, YanChun</au><au>Xie, Chuanmiao</au><au>Su, Changliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High b-Value and Ultra-High b-Value Diffusion Weighted MRI in Stroke</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2024-07-29</date><risdate>2024</risdate><issn>1053-1807</issn><issn>1522-2586</issn><eissn>1522-2586</eissn><abstract>To explore the application value of high-b-value and ultra-high b-value DWI in noninvasive evaluation of ischemic infarctions.
Prospective.
Sixty-four patients with clinically diagnosed ischemic lesions based on symptoms and DWI.
3.0 T/T2-weighted fast spin-echo, fluid-attenuated inversion recovery, pre-contrast T1-weighted magnetization prepared rapid gradient echo sequence, multi-b-value trace DWI and q-space sampling sequences.
Lesions were segmented on standard b-value DWI (SB-DWI, 1000 s/mm
), high b-value DWI (HB-DWI, 4000 s/mm
) and ultra-high b-value DWI (UB-DWI, 10,000 s/mm
), and cumulative segmented areas were the final abnormality volumes. Normal white matter (WM) areas were obtained after binarization of segmented brain. In 47 patients, fractional anisotropy (FA) and apparent diffusion coefficients (ADCs) at b values of 1000, 4000, and 10,000 s/mm
were extracted from symmetrical WM masks and lesion masks of contralateral WM (CWM) and lesion-side WM (LWM).
Wilcoxon matched-pairs signed-rank test and Pearson correlation analysis. Two-tailed P-values <0.05 were considered statistically significant.
Various signals of HB-/UB-DWI (hypo-, iso- or hyper-intensity) were observed in strokes compared with SB-DWI, and some areas with iso-intensity of SB-DWI manifested with hyper-intensity on HB-/UB-DWI. Abnormality volumes from SB-DWI were significantly smaller than those from HB-DWI and UB-DWI (10.32 ± 16.45 cm
, vs. 12.25 ± 19.71 cm
and 11.83 ± 19.41 cm
), while no significant difference exist in volume between HB-DWI and UB-DWI (P = 0.32). In CWM, FA significantly correlated with ADC
and ADC
(maximum r = -0.51 and -0.64), but did not significantly correlate with ADC
(maximum r = -0.20, P = 0.17). ADC
or ADC
of LWM not significant correlated with FA of CWM (maximum r = -0.28, P = 0.06), while ADC
of LWM significantly correlated with FA of CWM (maximum r = -0.46).
HB- and UB-DWI have potential to be supplementary tools for the noninvasive evaluation of stroke lesions in clinics.
2 TECHNICAL EFFICACY: Stage 2.</abstract><cop>United States</cop><pmid>39074845</pmid><doi>10.1002/jmri.29547</doi><orcidid>https://orcid.org/0000-0001-6959-0027</orcidid><orcidid>https://orcid.org/0000-0002-4418-5823</orcidid><orcidid>https://orcid.org/0000-0003-0064-4693</orcidid><orcidid>https://orcid.org/0000-0001-8533-623X</orcidid><orcidid>https://orcid.org/0009-0001-6083-4459</orcidid></addata></record> |
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| title | High b-Value and Ultra-High b-Value Diffusion Weighted MRI in Stroke |
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