The transcriptional repressor B cell lymphoma 6 regulates CXCR3 chemokine and human leukocyte antigen II expression in endothelial cells

Interferon gamma (IFN-γ) induces an endothelial proimmunogenic phenotype through the JAK/STAT1 pathway, which can shape the activation of alloreactive leukocytes in transplant rejection. In immune cells, the DNA-binding protein B cell lymphoma 6 (BCL6) controls the transcription of inflammatory gene...

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Veröffentlicht in:	American journal of transplantation 2024-12, Vol.24 (12), p.2157-2173
Hauptverfasser:	Franco Acevedo, Adriana, Mack, Julia J., Valenzuela, Nicole M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Chemokine CXCL9 - genetics Chemokine CXCL9 - metabolism chemokines endothelial cells Endothelial Cells - metabolism Gene Expression Regulation Graft Rejection - immunology Graft Rejection - metabolism Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - metabolism HLA Humans interferon gamma Interferon-gamma - metabolism Proto-Oncogene Proteins c-bcl-6 - genetics Proto-Oncogene Proteins c-bcl-6 - metabolism Receptors, CXCR3 - genetics Receptors, CXCR3 - metabolism
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