Ursolic Acid Conjugates: A New Frontier in Anticancer Drug Development

New Ursolic Acid (UA) conjugates were synthesized using optimized synthetic protocols through the molecular hybridization approach at C‐3 and C‐28. This resulted in the targeted molecules being produced in good yields. Some of the synthesized conjugates showed significantly relevant bioactivity agai...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2024-10, Vol.25 (20), p.e202400376-n/a
Hauptverfasser:	Bokhtia, Riham M., Pham, Ashley M., Bihari Gupta, Kunj, Warang, Shamta S., Venugopal, Natasha, Shakuja, Rajeev, Somanath, Payaningal R., Liu, Fang, Chang Jeon, Yi, Guimaraes, Guilherme J., Bartlett, Michael G., Thangaraju, Muthusamy, Lokeshwar, Bal. L., Panda, Siva S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Antineoplastic drugs Antiproliferatives Apoptosis Autophagy Biocompatibility Biological activity Bladder Bladder cancer Breast cancer Cell culture Cell death Chemical synthesis Chemotherapy Computational studies Conjugates Cytotoxicity Drug development Epithelial cells Epithelium Gemcitabine Hybridization Mammalian cells Molecular hybridization Molecular modelling Natural product Synthesis Toxicity Tumor cell lines Tumor cells Tumors Ursolic acid
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