Dietary supplementation with capsaicinoids alleviates obesity in mice fed a high-fat-high-fructose diet
Capsaicinoids are the pungent compounds in chili peppers. The present study investigated the effect of capsaicinoids on obesity in mice induced by a high-fat-high-fructose diet. Thirty-two male C57BL/6J mice were randomly divided into four groups ( n = 8) and fed one of the following diets, namely,...
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| creator | Chen, Zixing Liu, Jianhui Ding, Huafang Yan, Chi Zhu, Hanyue Huang, Shouhe Chen, Zhen-Yu |
| description | Capsaicinoids are the pungent compounds in chili peppers. The present study investigated the effect of capsaicinoids on obesity in mice induced by a high-fat-high-fructose diet. Thirty-two male C57BL/6J mice were randomly divided into four groups (
n
= 8) and fed one of the following diets, namely, a low-fat diet (LFD), a high-fat-high-fructose diet (HFF), an HFF + 0.015% capsaicinoids (LCP), and an HFF + 0.045% capsaicinoids (HCP), for 12 weeks. Results showed that capsaicinoids significantly reversed HFF-induced obesity. Supplementation with capsaicinoids improved glucose tolerance, reduced plasma lipids, and attenuated inflammation. Capsaicinoids also reduced hepatic lipid accumulation by upregulating the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). In addition, capsaicinoids enhanced the production of fecal short-chain fatty acids (SCFAs) and increased the fecal excretion of lipids. Gut microbiota analysis revealed that capsaicinoids decreased the
Firmicutes
/
Bacteroidetes
ratio and beneficially reconstructed the microbial community. However, the effects of capsaicinoids on intestinal villus length and lipid tolerance were negligible. In conclusion, capsaicinoids effectively attenuated HFF-induced obesity and metabolic syndrome by favorably modulating lipid metabolism, improving SCFA production, and reshaping gut microbial structure.
This study was the first to systematically investigate the anti-obesity effect of capsaicinoids and its relationship with intestinal villus length in mice fed a high-fat-high-fructose diet. |
| doi_str_mv | 10.1039/d4fo02102a |
| format | Article |
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n
= 8) and fed one of the following diets, namely, a low-fat diet (LFD), a high-fat-high-fructose diet (HFF), an HFF + 0.015% capsaicinoids (LCP), and an HFF + 0.045% capsaicinoids (HCP), for 12 weeks. Results showed that capsaicinoids significantly reversed HFF-induced obesity. Supplementation with capsaicinoids improved glucose tolerance, reduced plasma lipids, and attenuated inflammation. Capsaicinoids also reduced hepatic lipid accumulation by upregulating the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). In addition, capsaicinoids enhanced the production of fecal short-chain fatty acids (SCFAs) and increased the fecal excretion of lipids. Gut microbiota analysis revealed that capsaicinoids decreased the
Firmicutes
/
Bacteroidetes
ratio and beneficially reconstructed the microbial community. However, the effects of capsaicinoids on intestinal villus length and lipid tolerance were negligible. In conclusion, capsaicinoids effectively attenuated HFF-induced obesity and metabolic syndrome by favorably modulating lipid metabolism, improving SCFA production, and reshaping gut microbial structure.
This study was the first to systematically investigate the anti-obesity effect of capsaicinoids and its relationship with intestinal villus length in mice fed a high-fat-high-fructose diet.</description><identifier>ISSN: 2042-6496</identifier><identifier>ISSN: 2042-650X</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d4fo02102a</identifier><identifier>PMID: 39073607</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Capsaicin ; Capsaicin - pharmacology ; Capsicum - chemistry ; Diet ; Diet, High-Fat - adverse effects ; Dietary Supplements ; Digestive system ; Fatty Acids, Volatile - metabolism ; Fructose ; Fructose - adverse effects ; Gastrointestinal Microbiome - drug effects ; Gastrointestinal tract ; Glucose tolerance ; High fat diet ; Intestinal microflora ; Lipid metabolism ; Lipid Metabolism - drug effects ; Lipids ; Liver - drug effects ; Liver - metabolism ; Low fat diet ; Male ; Metabolic disorders ; Metabolic syndrome ; Mice ; Mice, Inbred C57BL ; Microbiota ; Microorganisms ; Nutrient deficiency ; Obesity ; Obesity - drug therapy ; Obesity - metabolism ; Peppers ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism ; Peroxisome proliferator-activated receptors ; Pungent principles ; Villus</subject><ispartof>Food & function, 2024-08, Vol.15 (16), p.8572-8585</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c226t-4e2371b984142b78d2670793c568effdd388d1c15461b186e2440a72ae03e533</cites><orcidid>0000-0001-5615-1682 ; 0000-0002-9313-5312 ; 0000-0001-5903-9098</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39073607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Zixing</creatorcontrib><creatorcontrib>Liu, Jianhui</creatorcontrib><creatorcontrib>Ding, Huafang</creatorcontrib><creatorcontrib>Yan, Chi</creatorcontrib><creatorcontrib>Zhu, Hanyue</creatorcontrib><creatorcontrib>Huang, Shouhe</creatorcontrib><creatorcontrib>Chen, Zhen-Yu</creatorcontrib><title>Dietary supplementation with capsaicinoids alleviates obesity in mice fed a high-fat-high-fructose diet</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Capsaicinoids are the pungent compounds in chili peppers. The present study investigated the effect of capsaicinoids on obesity in mice induced by a high-fat-high-fructose diet. Thirty-two male C57BL/6J mice were randomly divided into four groups (
n
= 8) and fed one of the following diets, namely, a low-fat diet (LFD), a high-fat-high-fructose diet (HFF), an HFF + 0.015% capsaicinoids (LCP), and an HFF + 0.045% capsaicinoids (HCP), for 12 weeks. Results showed that capsaicinoids significantly reversed HFF-induced obesity. Supplementation with capsaicinoids improved glucose tolerance, reduced plasma lipids, and attenuated inflammation. Capsaicinoids also reduced hepatic lipid accumulation by upregulating the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). In addition, capsaicinoids enhanced the production of fecal short-chain fatty acids (SCFAs) and increased the fecal excretion of lipids. Gut microbiota analysis revealed that capsaicinoids decreased the
Firmicutes
/
Bacteroidetes
ratio and beneficially reconstructed the microbial community. However, the effects of capsaicinoids on intestinal villus length and lipid tolerance were negligible. In conclusion, capsaicinoids effectively attenuated HFF-induced obesity and metabolic syndrome by favorably modulating lipid metabolism, improving SCFA production, and reshaping gut microbial structure.
This study was the first to systematically investigate the anti-obesity effect of capsaicinoids and its relationship with intestinal villus length in mice fed a high-fat-high-fructose diet.</description><subject>Animals</subject><subject>Capsaicin</subject><subject>Capsaicin - pharmacology</subject><subject>Capsicum - chemistry</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Dietary Supplements</subject><subject>Digestive system</subject><subject>Fatty Acids, Volatile - metabolism</subject><subject>Fructose</subject><subject>Fructose - adverse effects</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Gastrointestinal tract</subject><subject>Glucose tolerance</subject><subject>High fat diet</subject><subject>Intestinal microflora</subject><subject>Lipid metabolism</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipids</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Low fat diet</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Nutrient deficiency</subject><subject>Obesity</subject><subject>Obesity - drug therapy</subject><subject>Obesity - metabolism</subject><subject>Peppers</subject><subject>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics</subject><subject>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism</subject><subject>Peroxisome proliferator-activated receptors</subject><subject>Pungent principles</subject><subject>Villus</subject><issn>2042-6496</issn><issn>2042-650X</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0U1LxDAQBuAgioruxbsS8CJCNV9Nk6Ps-gWCFw_eSppM3Ujb1CZV9t9bXVfBXDKQh8kwL0JHlFxQwvWlE3UgjBJmttA-I4JlMifP25taaLmHZjG-kulwrZVWu2iPa1JwSYp99LLwkMywwnHs-wZa6JJJPnT4w6cltqaPxlvfBe8iNk0D794kiDhUEH1aYd_h1lvANThs8NK_LLPapGxdDKNNIQJ20xeHaKc2TYTZz32Anm6un-Z32cPj7f386iGzjMmUCWC8oJVWggpWFcoxWZBCc5tLBXXtHFfKUUtzIWlFlQQmBDEFM0A45JwfoLN1234IbyPEVLY-Wmga00EYY8mJyqWmnH7R03_0NYxDNw03KU21EFIWkzpfKzuEGAeoy37w7bSwkpLyK4ByIW4evwO4mvDJT8uxasH90s26J3C8BkO0v69_CfJPVeKJbw</recordid><startdate>20240812</startdate><enddate>20240812</enddate><creator>Chen, Zixing</creator><creator>Liu, Jianhui</creator><creator>Ding, Huafang</creator><creator>Yan, Chi</creator><creator>Zhu, Hanyue</creator><creator>Huang, Shouhe</creator><creator>Chen, Zhen-Yu</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5615-1682</orcidid><orcidid>https://orcid.org/0000-0002-9313-5312</orcidid><orcidid>https://orcid.org/0000-0001-5903-9098</orcidid></search><sort><creationdate>20240812</creationdate><title>Dietary supplementation with capsaicinoids alleviates obesity in mice fed a high-fat-high-fructose diet</title><author>Chen, Zixing ; Liu, Jianhui ; Ding, Huafang ; Yan, Chi ; Zhu, Hanyue ; Huang, Shouhe ; Chen, Zhen-Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-4e2371b984142b78d2670793c568effdd388d1c15461b186e2440a72ae03e533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Capsaicin</topic><topic>Capsaicin - pharmacology</topic><topic>Capsicum - chemistry</topic><topic>Diet</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Dietary Supplements</topic><topic>Digestive system</topic><topic>Fatty Acids, Volatile - metabolism</topic><topic>Fructose</topic><topic>Fructose - adverse effects</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Gastrointestinal tract</topic><topic>Glucose tolerance</topic><topic>High fat diet</topic><topic>Intestinal microflora</topic><topic>Lipid metabolism</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipids</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Low fat diet</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Nutrient deficiency</topic><topic>Obesity</topic><topic>Obesity - drug therapy</topic><topic>Obesity - metabolism</topic><topic>Peppers</topic><topic>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics</topic><topic>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism</topic><topic>Peroxisome proliferator-activated receptors</topic><topic>Pungent principles</topic><topic>Villus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Zixing</creatorcontrib><creatorcontrib>Liu, Jianhui</creatorcontrib><creatorcontrib>Ding, Huafang</creatorcontrib><creatorcontrib>Yan, Chi</creatorcontrib><creatorcontrib>Zhu, Hanyue</creatorcontrib><creatorcontrib>Huang, Shouhe</creatorcontrib><creatorcontrib>Chen, Zhen-Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Zixing</au><au>Liu, Jianhui</au><au>Ding, Huafang</au><au>Yan, Chi</au><au>Zhu, Hanyue</au><au>Huang, Shouhe</au><au>Chen, Zhen-Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary supplementation with capsaicinoids alleviates obesity in mice fed a high-fat-high-fructose diet</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2024-08-12</date><risdate>2024</risdate><volume>15</volume><issue>16</issue><spage>8572</spage><epage>8585</epage><pages>8572-8585</pages><issn>2042-6496</issn><issn>2042-650X</issn><eissn>2042-650X</eissn><abstract>Capsaicinoids are the pungent compounds in chili peppers. The present study investigated the effect of capsaicinoids on obesity in mice induced by a high-fat-high-fructose diet. Thirty-two male C57BL/6J mice were randomly divided into four groups (
n
= 8) and fed one of the following diets, namely, a low-fat diet (LFD), a high-fat-high-fructose diet (HFF), an HFF + 0.015% capsaicinoids (LCP), and an HFF + 0.045% capsaicinoids (HCP), for 12 weeks. Results showed that capsaicinoids significantly reversed HFF-induced obesity. Supplementation with capsaicinoids improved glucose tolerance, reduced plasma lipids, and attenuated inflammation. Capsaicinoids also reduced hepatic lipid accumulation by upregulating the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). In addition, capsaicinoids enhanced the production of fecal short-chain fatty acids (SCFAs) and increased the fecal excretion of lipids. Gut microbiota analysis revealed that capsaicinoids decreased the
Firmicutes
/
Bacteroidetes
ratio and beneficially reconstructed the microbial community. However, the effects of capsaicinoids on intestinal villus length and lipid tolerance were negligible. In conclusion, capsaicinoids effectively attenuated HFF-induced obesity and metabolic syndrome by favorably modulating lipid metabolism, improving SCFA production, and reshaping gut microbial structure.
This study was the first to systematically investigate the anti-obesity effect of capsaicinoids and its relationship with intestinal villus length in mice fed a high-fat-high-fructose diet.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>39073607</pmid><doi>10.1039/d4fo02102a</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5615-1682</orcidid><orcidid>https://orcid.org/0000-0002-9313-5312</orcidid><orcidid>https://orcid.org/0000-0001-5903-9098</orcidid></addata></record> |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Animals Capsaicin Capsaicin - pharmacology Capsicum - chemistry Diet Diet, High-Fat - adverse effects Dietary Supplements Digestive system Fatty Acids, Volatile - metabolism Fructose Fructose - adverse effects Gastrointestinal Microbiome - drug effects Gastrointestinal tract Glucose tolerance High fat diet Intestinal microflora Lipid metabolism Lipid Metabolism - drug effects Lipids Liver - drug effects Liver - metabolism Low fat diet Male Metabolic disorders Metabolic syndrome Mice Mice, Inbred C57BL Microbiota Microorganisms Nutrient deficiency Obesity Obesity - drug therapy Obesity - metabolism Peppers Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Peroxisome proliferator-activated receptors Pungent principles Villus |
| title | Dietary supplementation with capsaicinoids alleviates obesity in mice fed a high-fat-high-fructose diet |
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