Palladium‐Catalyzed Remote C−H Functionalization: Non‐Covalent Interactions and Reversibly Bound Templates

Pd‐catalysis has stood as a pivotal force in synthetic transformations for decades, maintaining its status as a paramount tool in the realm of C−H bond activation. While functionalization at proximal positions has become commonplace, achieving selective and sustainable access to distal positions continues to captivate scientific endeavors. Recently, a noteworthy trend has emerged, focusing on the utilization of non‐covalent interactions to address the challenges associated with remote functionalization. The integration of these non‐covalent interactions into palladium catalysis stands as a justified response to the demands of achieving selective transformations at distal positions. This review delves into the latest advancements and trends surrounding the incorporation of non‐covalent interactions within the field of palladium catalysis. Furthermore, it is noteworthy to emphasize that multifunctional templates, particularly those harnessing hydrogen bonding, present an elegant and sophisticated approach to activate C−H bonds in a highly directed fashion. These templates showcase versatility and demonstrate potential applications across diverse contexts within the area of remote functionalization. Utilization of non‐covalent interactions has now become the vogue in C−H bond functionalization chemistry. Exploration of such diverse interactions such as hydrogen bonding, Lewis acid‐base interactions etc. and their subsequent integration with palladium catalysis becomes pivotal in redefining the sustainability aspects associated with transition metal catalysis. The precise engineering of templates and their diligent correlation with respect to the substrate, becomes the cornerstone in these strategies.